Zobrazeno 1 - 10
of 30
pro vyhledávání: '"P E Poubelle"'
Autor:
Patrice E. Poubelle, Nathalie Pagé, Marie-Pier Longchamps, Natalia Sampaio Moura, David B. Beck, Ivona Aksentijevich, Philippe A. Tessier, Martin Pelletier
Publikováno v:
Clinical and Translational Medicine, Vol 8, Iss 1, Pp 1-10 (2019)
Abstract Background Biological agents have allowed remarkable improvement in controlling autoimmune arthropathies, although none of the numerous biologics readily available represent a universal treatment standard. Moreover, classical and genetic pre
Externí odkaz:
https://doaj.org/article/2b22c7caa26e48a6ac4cd3716497fc4c
Autor:
Yang Zhao, Stephan Hasse, Myriam Vaillancourt, Chenqi Zhao, Lynn Davis, Eric Boilard, Paul Fortin, John Di Battista, Patrice E. Poubelle, Sylvain G. Bourgoin
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12685 (2021)
Lysophosphatidylserine (lysoPS) is known to regulate immune cell functions. Phospholipase A1 member A (PLA1A) can generate this bioactive lipid through hydrolysis of sn-1 fatty acids on phosphatidylserine (PS). PLA1A has been associated with cancer m
Externí odkaz:
https://doaj.org/article/b65a1cf4393f452dbf137037cd027a6b
Autor:
Carolyn G. J. Moonen, Teun J. de Vries, Patrick Rijkschroeff, Patrice E. Poubelle, Elena A. Nicu, Bruno G. Loos
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
The ligand of the receptor activator of NF-κB (RANKL) is a key molecule in the formation of osteoclasts, the key cells that cause the disease-associated alveolar bone resorption in periodontitis. We hypothesized that polymorphonuclear leukocytes (PM
Externí odkaz:
https://doaj.org/article/e0784bcbcb0f433184ca58077adea348
Autor:
Chenqi Zhao, Anne Sardella, Jerold Chun, Patrice E. Poubelle, Maria J. Fernandes, Sylvain G. Bourgoin
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 7, Pp 1307-1318 (2011)
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid present in low concentrations in serum and biological fluids but in high concentrations at sites of inflammation. LPA evokes a variety of cellular responses via binding to and activation of
Externí odkaz:
https://doaj.org/article/23a733d2d2db454e95627c3fec29e49e
Autor:
Chenqi Zhao, Maria J. Fernandes, Mélanie Turgeon, Sabrina Tancrède, John Di Battista, Patrice E. Poubelle, Sylvain G. Bourgoin
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 11, Pp 2323-2337 (2008)
Sphingosine-1-phosphate (S1P), via interaction with its G protein-coupled receptors, regulates various physiological and pathological responses. The present study investigated the role of S1P/S1P receptor signaling in several functional responses of
Externí odkaz:
https://doaj.org/article/56280662c4524830b9d62c13c2816a4f
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109256 (2014)
IL-32γ is a multifunctional cytokine involved in various inflammatory and auto-immune diseases in which neutrophils can affect the evolution of these diseases. To persist at inflammatory sites, neutrophils require inhibition of their rapid and const
Externí odkaz:
https://doaj.org/article/d9682cb3dc804d9ca71da72c85959249
Publikováno v:
The Journal of Immunology. 163:3449-3458
Studies were undertaken to define the role of 5-lipoxygenase (5-LO) products and, in particular, of leukotriene (LT) B4 in the polymorphonuclear leukocyte (PMN) emigration process using a rabbit model of dermal inflammation. Our results show that i.v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b4f56f6040eb2c2d7bde3a417de247
https://doi.org/10.4049/jimmunol.163.6.3449
https://doi.org/10.4049/jimmunol.163.6.3449
Publikováno v:
The Journal of Immunology. 156:4884-4891
The present study investigated the effect of EBV on gene expression and protein synthesis of IL-1 and its natural IL-1R antagonist (IL-1Ra) in human peripheral blood neutrophils. EBV induced a rapid accumulation of IL-1 and IL-lRa mRNA in neutrophils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17fd5ca51e3a84d8863214d383cf9173
https://doi.org/10.4049/jimmunol.156.12.4884
https://doi.org/10.4049/jimmunol.156.12.4884
Publikováno v:
The Journal of Immunology. 155:3570-3577
MHC class II molecules expressed in lymphoid and nonlymphoid cells act as signal-transducer molecules. We demonstrate that engagement of MHC class II molecules on human IFN-gamma-treated fibroblast-like synoviocytes by their natural ligand, the staph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa2945241a4d4f0ada49e108e76db9eb
https://doi.org/10.4049/jimmunol.155.7.3570
https://doi.org/10.4049/jimmunol.155.7.3570
Publikováno v:
The Journal of Immunology. 152:5485-5494
Neutrophils produce IL-1 when stimulated by monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals. Neutrophils also generate the IL-1R antagonist (IL-1Ra), especially when incubated with granulocyte-macrophage CSF (GM-CSF) or TNF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ce769d205f4399c75c4cfccb2c2c630
https://doi.org/10.4049/jimmunol.152.11.5485
https://doi.org/10.4049/jimmunol.152.11.5485