Zobrazeno 1 - 10
of 32
pro vyhledávání: '"P E Polak"'
Autor:
Sofia Sirvent, Andres F. Vallejo, Emma Corden, Ying Teo, James Davies, Kalum Clayton, Eleanor G. Seaby, Chester Lai, Sarah Ennis, Rfeef Alyami, Gemma Douilhet, Lareb S. N. Dean, Matthew Loxham, Sarah Horswill, Eugene Healy, Graham Roberts, Nigel J. Hall, Peter S. Friedmann, Harinder Singh, Clare L. Bennett, Michael R Ardern-Jones, Marta E. Polak
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Regulation of cutaneous immunity is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic dermatitis, we utilise a human in vivo allergen challenge stud
Externí odkaz:
https://doaj.org/article/8a9e3b6f395949309fb497cf8ddaabc0
Autor:
Luc J.H.J. Theunissen, Jeroen A.A. van de Pol, Gijs J. van Steenbergen, Henricus-Paul Cremers, Dennis van Veghel, Pepijn H. van der Voort, Peter E. Polak, Sylvie F.A.M.S. de Jong, Jaap Seelig, Geert Smits, Hareld M.C. Kemps, Lukas R.C. Dekker
Publikováno v:
Health and Quality of Life Outcomes, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background In this study, the prognostic value of AF-related quality of life (AFEQT) at baseline on Major Adverse Cardiovascular Events (MACE) and improvement of perceived symptoms (EHRA) was assessed. Furthermore, the relationship between Q
Externí odkaz:
https://doaj.org/article/3f12ef2637bf4f86bc6317ad6ba669a4
Autor:
Luc J. H. J. Theunissen, Henricus‐Paul Cremers, Dennis vanVeghel, Pepijn H. van derVoort, Peter E. Polak, Sylvie F. A. M. S. deJong, Geert Smits, Jos Dijkmans, Hareld M. C. Kemps, Lukas R. C. Dekker, Jeroen A. A. van dePol
Publikováno v:
Journal of Arrhythmia, Vol 38, Iss 1, Pp 50-57 (2022)
Abstract Background In this study, the relationship between AF‐related quality of life (AFEQT) at baseline in AF‐patients and the improvement on perceived symptoms and general state of health (EHRA, European Heart Rhythm Association score) at 12
Externí odkaz:
https://doaj.org/article/54d93635439443f39ff4b27e0f6b5752
Autor:
James Davies, Sofia Sirvent, Andres F. Vallejo, Kalum Clayton, Gemma Douilhet, Patrick S. Keeler, Jonathan West, Michael Ardern-Jones, Ben D. MacArthur, Harinder Singh, Marta E. Polak
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Human epidermal Langerhans cells (LCs) maintain immune homeostasis in the skin. To examine transcriptional programming of human primary LCs during homeostasis, we performed scRNA-seq analysis of LCs before and after migration from the epidermis, coup
Externí odkaz:
https://doaj.org/article/01eb019a31594305b0a55201ee8ed5e5
Autor:
Rebekah Penrice-Randal, Xiaofeng Dong, Andrew George Shapanis, Aaron Gardner, Nicholas Harding, Jelmer Legebeke, Jenny Lord, Andres F. Vallejo, Stephen Poole, Nathan J. Brendish, Catherine Hartley, Anthony P. Williams, Gabrielle Wheway, Marta E. Polak, Fabio Strazzeri, James P. R. Schofield, Paul J. Skipp, Julian A. Hiscox, Tristan W. Clark, Diana Baralle
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundThe COVID-19 pandemic has created pressure on healthcare systems worldwide. Tools that can stratify individuals according to prognosis could allow for more efficient allocation of healthcare resources and thus improved patient outcomes. It
Externí odkaz:
https://doaj.org/article/919dbb10fdda47859e6b536e0d1cbd3a
Autor:
Leilane Oliveira Gonçalves, Andrés F. Vallejo Pulido, Fernando Augusto Siqueira Mathias, Alexandre Estevão Silvério Enes, Maria Gabriela Reis Carvalho, Daniela de Melo Resende, Marta E. Polak, Jeronimo C. Ruiz
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Leishmania amazonensis and Leishmania major are the causative agents of cutaneous and mucocutaneous diseases. The infections‘ outcome depends on host–parasite interactions and Th1/Th2 response, and in cutaneous form, regulation of Th17 cytokines
Externí odkaz:
https://doaj.org/article/63f8b76b136e447eb52c9620b10e1355
Autor:
Heather C. West, James Davies, Stephen Henderson, Oluyori K. Adegun, Sophie Ward, Ivana R. Ferrer, Chanidapa A. Tye, Andres F. Vallejo, Laura Jardine, Matthew Collin, Marta E. Polak, Clare L. Bennett
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110819- (2022)
Summary: T cell pathology in the skin leads to monocyte influx, but we have little understanding of the fate of recruited cells within the diseased niche, or the long-term impact on cutaneous immune homeostasis. By combining a murine model of acute g
Externí odkaz:
https://doaj.org/article/960eba7bb8e8431f8c5a9ff4e7e81b08
Autor:
Jelmer Legebeke, Jenny Lord, Rebekah Penrice-Randal, Andres F. Vallejo, Stephen Poole, Nathan J. Brendish, Xiaofeng Dong, Catherine Hartley, John W. Holloway, Jane S. Lucas, Anthony P. Williams, Gabrielle Wheway, Fabio Strazzeri, Aaron Gardner, James P. R. Schofield, Paul J. Skipp, Julian A. Hiscox, Marta E. Polak, Tristan W. Clark, Diana Baralle
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The worldwide COVID-19 pandemic has claimed millions of lives and has had a profound effect on global life. Understanding the body’s immune response to SARS-CoV-2 infection is crucial in improving patient management and prognosis. In this study we
Externí odkaz:
https://doaj.org/article/f46b555a1c314f3fb50bd6cabe819aa8
Autor:
Sofia Sirvent, Andres F. Vallejo, James Davies, Kalum Clayton, Zhiguo Wu, Jeongmin Woo, Jeremy Riddell, Virendra K. Chaudhri, Patrick Stumpf, Liliya Angelova Nazlamova, Gabrielle Wheway, Matthew Rose-Zerilli, Jonathan West, Mario Pujato, Xiaoting Chen, Christopher H. Woelk, Ben MacArthur, Michael Ardern-Jones, Peter S. Friedmann, Matthew T. Weirauch, Harinder Singh, Marta E. Polak
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in the skin. Here the authors show, by transcriptomic, epigenetic and CRISPR editing analyses, that during LC migration and maturation the transcription factor IRF4 regulate
Externí odkaz:
https://doaj.org/article/b437083920e842f086e6d17c31b3b048
Autor:
James Davies, Andres F. Vallejo, Sofia Sirvent, Gemma Porter, Kalum Clayton, Yamkela Qumbelo, Patrick Stumpf, Jonathan West, Clive M. Gray, Nyaradzo T. L. Chigorimbo-Murefu, Ben MacArthur, Marta E. Polak
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels, coordinating both immunogenic and tolerogenic immune responses. To determine molecular switches directing induction of LC immune activation, we performed ma
Externí odkaz:
https://doaj.org/article/46f330235a8f433f86a4e4a607fe5ba0