Zobrazeno 1 - 9
of 9
pro vyhledávání: '"P E Kima"'
Autor:
Jeff M. Gruntmeir, Jeff R. Abbott, Peter E. Kima, Maureen T. Long, Byron L. Blagburn, Heather S. Walden
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-10 (2023)
Abstract Background Immune complexing of target antigen to high affinity host antibody is recognized to impact the sensitivity of commercial heartworm antigen tests. Published information describing the effect of heat on interfering canine host antib
Externí odkaz:
https://doaj.org/article/11bbf056397444879a469a436ed39bb7
Autor:
Evan Craig, Anna Calarco, Raffaele Conte, Veronica Ambrogi, Giovanna Gomez d’Ayala, Philip Alabi, Jason K. Sello, Pierfrancesco Cerruti, Peter E. Kima
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Clinical manifestations of leishmaniasis range from self-healing, cutaneous lesions to fatal infections of the viscera. With no preventative Leishmania vaccine available, the frontline option against leishmaniasis is chemotherapy. Unfortunately, curr
Externí odkaz:
https://doaj.org/article/fbf6f700420e4edbaa3fd4ce339c114f
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Extracellular vesicles (EVs) have garnered significant interest in recent years due to their contributions to cell-to-cell communication and disease processes. EVs are composed of a complex profile of bioactive molecules, which include lipids, nuclei
Externí odkaz:
https://doaj.org/article/6dd82539a184445982aa93a47ace272d
Autor:
Mariola J. Edelmann, Peter E. Kima
Publikováno v:
Zoonoses, Vol 2, Iss 1, p 986 (2022)
Extracellular vesicles (EVs) are membrane-enclosed packets that are released from cells and subsequently transfer bioactive molecules between cells without directly contacting the target cells. This transfer of molecules can activate consequential pr
Externí odkaz:
https://doaj.org/article/305b0d8181614d17be6e0c38a9c71ff0
Miransertib (ARQ 092), an orally-available, selective Akt inhibitor is effective against Leishmania.
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206920 (2018)
Leishmaniasis is amongst the most important neglected diseases, afflicting more than 12 million people in 88 countries. There is an urgent need for safe orally bioavailable and cost-effective drugs for the treatment of leishmaniasis. It has recently
Externí odkaz:
https://doaj.org/article/f874de40be894a958c4c4154e53fb924
Autor:
Evan Craig, Charles-Eugene Huyghues-Despointes, Chun Yu, Emma L Handy, Jason K Sello, Peter E Kima
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005556 (2017)
In infected mammalian cells, Leishmania parasites reside within specialized compartments called parasitophorous vacuoles (LPVs). We have previously shown that Retro-2, a member of a novel class of small retrograde pathway inhibitors caused reduced LP
Externí odkaz:
https://doaj.org/article/bf7770f55c804ed49eee5c3ec3267f42
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e3000 (2014)
Professional phagocytes generate a myriad of antimicrobial molecules to kill invading microorganisms, of which nitrogen oxides are integral in controlling the obligate intracellular pathogen Leishmania. Although reactive nitrogen species produced by
Externí odkaz:
https://doaj.org/article/677b761cba0c4421913fbcde19bb77a5
Autor:
Peter E Kima, J Alfredo Bonilla, Eumin Cho, Blaise Ndjamen, Johnathan Canton, Nicole Leal, Martin Handfield
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 10 (2010)
Although Leishmania parasites have been shown to modulate their host cell's responses to multiple stimuli, there is limited evidence that parasite molecules are released into infected cells. In this study, we present an implementation of the change m
Externí odkaz:
https://doaj.org/article/7e966181a4a34f76b9a22b5d255ffe02
Publikováno v:
The Journal of Immunology. 159:1828-1834
CD8+ T cells play a protective role in immunity to cutaneous leishmaniasis. However, it has been unclear how these cells execute this function, since results from several investigations attempting to demonstrate recognition of Leishmania-infected mac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3632bf4f3201d97b29fa41daff132152
https://doi.org/10.4049/jimmunol.159.4.1828
https://doi.org/10.4049/jimmunol.159.4.1828