Zobrazeno 1 - 10
of 27
pro vyhledávání: '"P E Higgs"'
Autor:
L McClenachan, T Rick, RH Thurstan, A Trant, PS Alagona, HK Alleway, C Armstrong, R Bliege Bird, NT Rubio-Cisneros, M Clavero, AC Colonese, K Cramer, AO Davis, J Drew, MM Early-Capistrán, G Gil-Romera, M Grace, MBA Hatch, E Higgs, K Hoffman, JBC Jackson, A Jerardino, MJ LeFebvre, HK Lotze, RS Mohammed, N Morueta-Holme, C Munteanu, AM Mychajliw, B Newsom, A O’Dea, D Pauly, P Szabó, J Torres, J Waldman, C West, L Xu, H Yasuoka, PSE zu Ermgassen, KS Van Houtan
Publikováno v:
Endangered Species Research, Vol 54, Pp 285-310 (2024)
Historical ecology draws on a broad range of information sources and methods to provide insight into ecological and social change, especially over the past ∼12000 yr. While its results are often relevant to conservation and restoration, insights fr
Externí odkaz:
https://doaj.org/article/1a6a94dcabfe49059bc0e8c5d0582aad
Autor:
Jonathan T. Sims, Josh Poorbaugh, Ching-Yun Chang, Timothy R. Holzer, Lin Zhang, Sarah M. Engle, Stephanie Beasley, Thompson N. Doman, Lynn Naughton, Richard E. Higgs, Nicole Kallewaard, Robert J. Benschop
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background A thorough understanding of a patient’s inflammatory response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is crucial to discerning the associated, underlying immunological processes and to the selec
Externí odkaz:
https://doaj.org/article/bdd024c53d764522a92238a2eb84f962
Autor:
Kathryn Westendorf, Stefanie Žentelis, Lingshu Wang, Denisa Foster, Peter Vaillancourt, Matthew Wiggin, Erica Lovett, Robin van der Lee, Jörg Hendle, Anna Pustilnik, J. Michael Sauder, Lucas Kraft, Yuri Hwang, Robert W. Siegel, Jinbiao Chen, Beverly A. Heinz, Richard E. Higgs, Nicole L. Kallewaard, Kevin Jepson, Rodrigo Goya, Maia A. Smith, David W. Collins, Davide Pellacani, Ping Xiang, Valentine de Puyraimond, Marketa Ricicova, Lindsay Devorkin, Caitlin Pritchard, Aoise O’Neill, Kush Dalal, Pankaj Panwar, Harveer Dhupar, Fabian A. Garces, Courtney A. Cohen, John M. Dye, Kathleen E. Huie, Catherine V. Badger, Darwyn Kobasa, Jonathan Audet, Joshua J. Freitas, Saleema Hassanali, Ina Hughes, Luis Munoz, Holly C. Palma, Bharathi Ramamurthy, Robert W. Cross, Thomas W. Geisbert, Vineet Menachery, Kumari Lokugamage, Viktoriya Borisevich, Iliana Lanz, Lisa Anderson, Payal Sipahimalani, Kizzmekia S. Corbett, Eun Sung Yang, Yi Zhang, Wei Shi, Tongqing Zhou, Misook Choe, John Misasi, Peter D. Kwong, Nancy J. Sullivan, Barney S. Graham, Tara L. Fernandez, Carl L. Hansen, Ester Falconer, John R. Mascola, Bryan E. Jones, Bryan C. Barnhart
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110812- (2022)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibodies (mAbs) can reduce the risk of hospitalization from coronavirus disease 2019 (COVID-19) when administered early. However, SARS-CoV-2 variants of c
Externí odkaz:
https://doaj.org/article/daeff3ff2f814504a3643f35bb419fcf
Autor:
Lin Zhang, Josh Poorbaugh, Michael Dougan, Peter Chen, Robert L. Gottlieb, Gregory Huhn, Stephanie Beasley, Montanea Daniels, Thi Ngoc Vy Trinh, Melissa Crisp, Joshua Joaquin Freitas, Peter Vaillancourt, Dipak R. Patel, Ajay Nirula, Nicole L. Kallewaard, Richard E. Higgs, Robert J. Benschop
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundNeutralizing monoclonal antibodies (mAbs) to SARS-CoV-2 are clinically efficacious when administered early, decreasing hospitalization and mortality in patients with mild or moderate COVID-19. We investigated the effects of receiving mAbs (
Externí odkaz:
https://doaj.org/article/2989bd8ebc794edc93eb3dcb73825ce6
Autor:
Iain B. McInnes, Nicole L. Byers, Richard E. Higgs, Jonathan Lee, William L. Macias, Songqing Na, Robert A. Ortmann, Guilherme Rocha, Terence P. Rooney, Thomas Wehrman, Xin Zhang, Steven H. Zuckerman, Peter C. Taylor
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-10 (2019)
Abstract Background The in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the cellular level. Methods Peripheral blood mononuclear cells from healthy dono
Externí odkaz:
https://doaj.org/article/9199674c675b4aa38a99899ed7156b79
Autor:
Daniel J Wallace, Michelle A Petri, Thomas Dörner, Stephanie de Bono, Robert J Benschop, Ernst R Dow, Damiano Fantini, Richard E Higgs, Guilherme Rocha, Brenda Crowe, Nicole L Byers, Maria E Silk, Robert W Hoffman
Publikováno v:
Lupus Science and Medicine, Vol 7, Iss 1 (2020)
Objective To characterise the molecular pathways impacted by the pharmacologic effects of the Janus kinase (JAK) 1 and JAK2 inhibitor baricitinib in SLE.Methods In a phase II, 24-week, randomised, placebo-controlled, double-blind study (JAHH), RNA wa
Externí odkaz:
https://doaj.org/article/e5cc766cafc64ce9bf61c760b2589fcd
Autor:
Justin Stebbing, Venkatesh Krishnan, Stephanie deBono, Silvia Ottaviani, Giacomo Casalini, Peter J Richardson, Vanessa Monteil, Volker M Lauschke, Ali Mirazimi, Sonia Youhanna, Yee‐Joo Tan, Fausto Baldanti, Antonella Sarasini, Jorge A Ross Terres, Brian J Nickoloff, Richard E Higgs, Guilherme Rocha, Nicole L Byers, Douglas E Schlichting, Ajay Nirula, Anabela Cardoso, Mario Corbellino, the Sacco Baricitinib Study Group
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 8, Pp n/a-n/a (2020)
Abstract Baricitinib is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI) algorithms, to be useful for COVID‐19 infection via prop
Externí odkaz:
https://doaj.org/article/1380cc483c5c41d9b6607430fabfaf22
Autor:
Yupeng Li, Richard E Higgs, Robert W Hoffman, Ernst R Dow, Xiong Liu, Michelle Petri, Daniel J Wallace, Thomas Dörner, Brian J Eastwood, Bradley B Miller, Yushi Liu
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0225651 (2019)
Systemic lupus erythematosus (SLE) is a chronic, remitting, and relapsing, inflammatory disease involving multiple organs, which exhibits abnormalities of both the innate and adaptive immune responses. A limited number of transcriptomic studies have
Externí odkaz:
https://doaj.org/article/1b9cd46cacc0481ca99c2ae76363e69e
Autor:
Kevin Duffin, Kwan Hui, Donetta Gifford-Moore, Xiao-di Huang, Pamela G Rutherford, Nancy K Jackson, John E Hale, Li-Chun Chio, Eugene Zhen, Richard E Higgs, Shuguang Huang, Chung-Wein Lee, Karen Cox, Eileen McCall, Birong Liao, Kenneth E Gould, Mark Rekhter
Publikováno v:
Biomarker Insights, Vol 3, Pp 147-157 (2008)
Background: Current drug therapy of atherosclerosis is focused on treatment of major risk factors, e.g. hypercholesterolemia while in the future direct disease modification might provide additional benefits. However, development of medicines targetin
Externí odkaz:
https://doaj.org/article/c60e5078af034c7d87387ef96cc610fb
Autor:
Ying Chen, Jeremy McGee, Xianming Chen, Thompson N Doman, Xueqian Gong, Youyan Zhang, Nicole Hamm, Xiwen Ma, Richard E Higgs, Shripad V Bhagwat, Sean Buchanan, Sheng-Bin Peng, Kirk A Staschke, Vipin Yadav, Yong Yue, Hosein Kouros-Mehr
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98293 (2014)
The Cancer Genome Atlas (TCGA) projects have advanced our understanding of the driver mutations, genetic backgrounds, and key pathways activated across cancer types. Analysis of TCGA datasets have mostly focused on somatic mutations and translocation
Externí odkaz:
https://doaj.org/article/a29e5a4806f34d02a21d59875c6c8e59