Zobrazeno 1 - 10
of 148
pro vyhledávání: '"P E Carson"'
Autor:
William E. Carson, Samantha Major, Harshitha Akkineni, Hannah Fung, Elias Peters, Kimberly L. H. Carpenter, Geraldine Dawson, David E. Carlson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract A concern in the field of autism electroencephalography (EEG) biomarker discovery is their lack of reproducibility. In the present study, we considered the problem of learning reproducible associations between multiple features of resting st
Externí odkaz:
https://doaj.org/article/515dc8df69fb447dbb4d0a52b1972e59
Autor:
Jason Bini PhD, Jordan Strober PhD, Michael Kapinos BS, Ming-Qiang Zheng PhD, Songye Li PhD, Jim Ropchan PhD, Nabeel Nabulsi PhD, Yiyun Huang PhD, Rachel J. Perry PhD, Daniel F. Vatner MD, PhD, Richard E. Carson PhD
Publikováno v:
Molecular Imaging, Vol 23 (2024)
Background In rodents, 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) catalyzes the conversion of inactive 11-dehydrocorticosterone to the active hormone corticosterone. Dysregulation of intracellular glucocorticoid action is implicated in metabolic
Externí odkaz:
https://doaj.org/article/19e4e4be1641404aa0528d7e3905fd0e
Autor:
Emily M. Ringwalt, Mark A. Currier, Andrea M. Glaspell, Chun-Yu Chen, Matthew V. Cannon, Maren Cam, Amy C. Gross, Matthew Gust, Pin-Yi Wang, Louis Boon, Laura E. Biederman, Emily Schwarz, Prajwal Rajappa, Dean A. Lee, Elaine R. Mardis, William E. Carson, 3rd, Ryan D. Roberts, Timothy P. Cripe
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 4, Pp 200886- (2024)
We previously reported that the DNA alkylator and transcriptional-blocking chemotherapeutic agent trabectedin enhances oncolytic herpes simplex viroimmunotherapy in human sarcoma xenograft models, though the mechanism remained to be elucidated. Here
Externí odkaz:
https://doaj.org/article/9f97543ab8ef4ba1b69298b70f6f6188
Autor:
J. C. Chen, Mohamed I. Elsaid, Demond Handley, Lisa Anderson, Barbara L. Andersen, William E. Carson, Joal D. Beane, Alex Kim, Roman Skoracki, Timothy M. Pawlik, Samilia Obeng-Gyasi
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-7 (2024)
Abstract Allostatic load (AL) is a biological measure of cumulative exposure to socioenvironmental stressors (e.g., poverty). This study aims to examine the association between allostatic load (AL) and postoperative complications (POC) among patients
Externí odkaz:
https://doaj.org/article/0d4cd1125dce46a1bc35183464893cc5
Autor:
Molly K. Grun, Praveen Honhar, Yazhe Wang, Samantha Rossano, Minsoo Khang, Hee Won Suh, Krista Fowles, Harvey J. Kliman, Alessandra Cavaliere, Richard E. Carson, Bernadette Marquez‐Nostra, W. Mark Saltzman
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 5, Pp n/a-n/a (2024)
Abstract Long‐lasting vaginal dosage forms could improve the therapeutic efficacy of vaginal microbicides, but achieving long‐term delivery to the vaginal canal has been a significant challenge. To advance understanding of vaginal dosage retentio
Externí odkaz:
https://doaj.org/article/b589bf4c529e4236869af6ce392d93fa
Autor:
Sophie E. Holmes, Praveen Honhar, Sule Tinaz, Mika Naganawa, Ansel T. Hilmer, Jean-Dominique Gallezot, Mark Dias, Yanghong Yang, Takuya Toyonaga, Irina Esterlis, Adam Mecca, Christopher Van Dyck, Shannan Henry, Jim Ropchan, Nabeel Nabulsi, Elan D. Louis, Robert Comley, Sjoerd J. Finnema, Richard E. Carson, David Matuskey
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Parkinson’s disease (PD) is the fastest growing neurodegenerative disease, but at present there is no cure, nor any disease-modifying treatments. Synaptic biomarkers from in vivo imaging have shown promise in imaging loss of synapses in PD
Externí odkaz:
https://doaj.org/article/f8c1054730b44122933ba28992365acc
Autor:
Christopher H. van Dyck, Adam P. Mecca, Ryan S. O’Dell, Hugh H. Bartlett, Nina G. Diepenbrock, Yiyun Huang, Mary E. Hamby, Michael Grundman, Susan M. Catalano, Anthony O. Caggiano, Richard E. Carson
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Effective, disease-modifying therapeutics for the treatment of Alzheimer’s disease (AD) remain a large unmet need. Extensive evidence suggests that amyloid beta (Aβ) is central to AD pathophysiology, and Aβ oligomers are among
Externí odkaz:
https://doaj.org/article/f8737e4097cf48b39181feb795adf981
Autor:
Ronan C. Bracken, Lindsay M. Davison, Dennis P. Buehler, Maci E. Fulton, Emily E. Carson, Quanhu Sheng, Lindsey K. Stolze, Christelle Guillermier, Matthew L. Steinhauser, Jonathan D. Brown
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110011- (2024)
Summary: Combinatorial signaling by proinflammatory cytokines synergizes to exacerbate toxicity to cells and tissue injury during acute infections. To explore synergism at the gene-regulatory level, we investigated the dynamics of transcription and c
Externí odkaz:
https://doaj.org/article/968e40391d4f4f4f936e241935d0f84b
Autor:
Dionisia Quiroga DO, PhD, Robert Wesolowski MD, Sara Zelinskas BS, Ashley Pinette MD, Brooke Benner PhD, Emily Schwarz BS, Himanshu Savardekar BS, Courtney Johnson DO, Andrew Stiff MD, PhD, Lianbo Yu PhD, Erin Macrae MD, Maryam Lustberg MD, MPH, Ewa Mrozek MD, Bhuvaneswari Ramaswamy MD, William E. Carson MD
Publikováno v:
Cancer Control, Vol 31 (2024)
Objectives CpG ODN is a Toll-like receptor 9 agonist with immunotherapeutic potential for many cancer types, including aggressive breast cancers. There is strong interest in utilizing CpG ODN as an adjuvant to improve clinical efficacy of current tre
Externí odkaz:
https://doaj.org/article/c4a04ac8a9714a0fa31cf6f588fbd325
Autor:
Tommaso Volpi, Lucia Maccioni, Maria Colpo, Giulia Debiasi, Amedeo Capotosti, Tommaso Ciceri, Richard E. Carson, Christine DeLorenzo, Andreas Hahn, Gitte Moos Knudsen, Adriaan A. Lammertsma, Julie C. Price, Vesna Sossi, Guobao Wang, Paolo Zanotti-Fregonara, Alessandra Bertoldo, Mattia Veronese
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Background The need for arterial blood data in quantitative PET research limits the wider usability of this imaging method in clinical research settings. Image-derived input function (IDIF) approaches have been proposed as a cost-effective a
Externí odkaz:
https://doaj.org/article/09297a4d1afa43e2bc6a7fe55f221ea4