Zobrazeno 1 - 10
of 19
pro vyhledávání: '"P E, Szabó"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Dendritic spines are the primary sites of excitatory transmission in the mammalian brain. Spines of cerebellar Purkinje Cells (PCs) are plastic, but they differ from forebrain spines in a number of important respects, and the mechanisms of s
Externí odkaz:
https://doaj.org/article/4be1d67a006247b7807610b9f8c0f748
Autor:
Tie-Bo Zeng, Nicholas Pierce, Ji Liao, Purnima Singh, Kin Lau, Wanding Zhou, Piroska E. Szabó
Publikováno v:
PLoS Genetics, Vol 17, Iss 11 (2021)
EHMT2 is the main euchromatic H3K9 methyltransferase. Embryos with zygotic, or maternal mutation in the Ehmt2 gene exhibit variable developmental delay. To understand how EHMT2 prevents variable developmental delay we performed RNA sequencing of muta
Externí odkaz:
https://doaj.org/article/07cfe93f4d4c429a8647ea0c1b891960
Autor:
Shraddha Pai, Peipei Li, Bryan Killinger, Lee Marshall, Peixin Jia, Ji Liao, Arturas Petronis, Piroska E. Szabó, Viviane Labrie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Dopamine dysregulation is centrally linked to major psychosis. Here, the authors characterise the hypomethylation of an enhancer within the insulin-like growth factor 2 gene in neurons of patients with major psychosis and provide evidence that this e
Externí odkaz:
https://doaj.org/article/92406a1645fa465a86fc451c78740010
Autor:
Ji Liao, Tie-Bo Zeng, Nicholas Pierce, Diana A. Tran, Purnima Singh, Jeffrey R. Mann, Piroska E. Szabó
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108729- (2021)
Summary: Beckwith-Wiedemann syndrome (BWS) and Silver-Russell syndrome (SRS) are imprinting disorders manifesting as aberrant fetal growth and severe postnatal-growth-related complications. Based on the insulator model, one-third of BWS cases and two
Externí odkaz:
https://doaj.org/article/3c6bac68b35c49c3ac02056d59a4d489
Autor:
Ádám Sipos, Eszter Szennyes, Nikolett Éva Hajnal, Sándor Kun, Katalin E. Szabó, Karen Uray, László Somsák, Tibor Docsa, Éva Bokor
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 364 (2021)
A current trend in the quest for new therapies for complex, multifactorial diseases, such as diabetes mellitus (DM), is to find dual or even multi-target inhibitors. In DM, the sodium dependent glucose cotransporter 2 (SGLT2) in the kidneys and the g
Externí odkaz:
https://doaj.org/article/123aa2e339ec4bb68099bd3b1990d15b
Autor:
Seung-Gi Jin, Zhi-Min Zhang, Thomas L. Dunwell, Matthew R. Harter, Xiwei Wu, Jennifer Johnson, Zheng Li, Jiancheng Liu, Piroska E. Szabó, Qiang Lu, Guo-liang Xu, Jikui Song, Gerd P. Pfeifer
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 493-505 (2016)
We report that the mammalian 5-methylcytosine (5mC) oxidase Tet3 exists as three major isoforms and characterized the full-length isoform containing an N-terminal CXXC domain (Tet3FL). This CXXC domain binds to unmethylated CpGs, but, unexpectedly, i
Externí odkaz:
https://doaj.org/article/47abb58ffc4b449a8f329dae7b4c6882
Autor:
Purnima Singh, Arthur X. Li, Diana A. Tran, Nathan Oates, Eun-Rim Kang, Xiwei Wu, Piroska E. Szabó
Publikováno v:
Cell Reports, Vol 4, Iss 1, Pp 205-219 (2013)
To understand what dictates the emerging patterns of de novo DNA methylation in the male germline, we mapped DNA methylation, chromatin, and transcription changes in purified fetal mouse germ cells by using methylated CpG island recovery assay (MIRA)
Externí odkaz:
https://doaj.org/article/5241f3eb132e4969a8f4eeb172adb729
Autor:
Csaba Kerepesi, Judit E Szabó, Veronika Papp-Kádár, Orsolya Dobay, Dóra Szabó, Vince Grolmusz, Beata G Vertessy
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Fine-tuned regulation of the cellular nucleotide pools is indispensable for faithful replication of DNA. The genetic information is also safeguarded by DNA damage recognition and repair processes. Uracil is one of the most frequently occurring errone
Externí odkaz:
https://doaj.org/article/b4111ab7d87c4acd8bd6d46aac9a70d8
Publikováno v:
Biologia Plantarum, Vol 56, Iss 3, Pp 551-559 (2012)
The leaf apoplast is a dynamic compartment in contact with plant pathogenic bacteria after infection. Among the very first interaction events is the receptor-mediated perception of bacterial surface molecules such as flagellin or other conserved micr
Externí odkaz:
https://doaj.org/article/4f5ba88652fe46eea4b770955b282e48
Publikováno v:
Molecules, Vol 22, Iss 10, p 1760 (2017)
Reactions of O-peracylated C-(1-bromo-β-d-glucopyranosyl)formamides with thioamides furnished the corresponding glucopyranosylidene-spiro-thiazolin-4-one. While O-debenzoylations under a variety of conditions resulted in decomposition, during O-deac
Externí odkaz:
https://doaj.org/article/798f1952c0304e67abeab1655ec4990e