Zobrazeno 1 - 10
of 42
pro vyhledávání: '"P E, Mead"'
Autor:
Jacob L. Steenwyk, Sonja Knowles, Rafael W. Bastos, Charu Balamurugan, David Rinker, Matthew E. Mead, Christopher D. Roberts, Huzefa A. Raja, Yuanning Li, Ana Cristina Colabardini, Patrícia Alves de Castro, Thaila Fernanda dos Reis, Adiyantara Gumilang, María Almagro-Molto, Alexandre Alanio, Dea Garcia-Hermoso, Endrews Delbaje, Laís Pontes, Camila Figueiredo Pinzan, Angélica Zaninelli Schreiber, David Canóvas, Rafael Sanchez Luperini, Katrien Lagrou, Egídio Torrado, Fernando Rodrigues, Nicholas H. Oberlies, Xiaofan Zhou, Gustavo H. Goldman, Antonis Rokas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Cryptic fungal pathogens pose disease management challenges due to their morphological resemblance to known pathogens. Here, we investigated the genomes and phenotypes of 53 globally distributed isolates of Aspergillus section Nidulantes fun
Externí odkaz:
https://doaj.org/article/5b9dafe24b2b40d18c7832764b5d79b9
Autor:
Mikala M. Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E. Mead, Zachary A. Kipp, Evelyn A. Bates, Venkateshwari Varadharajan, Rakhee Banerjee, Se-Hyung Park, Nathan R. Shelman, Harrison A. Clarke, Tara R. Hawkinson, Terrymar Medina, Ramon C. Sun, Todd A. Lydic, Terry D. Hinds, Jr., J. Mark Brown, Samir Softic, Gregory A. Graf, Robert N. Helsley
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101815- (2023)
Background and aims: Genome and epigenome wide association studies identified variants in carnitine palmitoyltransferase 1a (CPT1a) that associate with lipid traits. The goal of this study was to determine the role of liver-specific CPT1a on hepatic
Externí odkaz:
https://doaj.org/article/2e4f326f6761408c9020ccde9aaab299
Autor:
Alex S Genshaft, Carly G. K. Ziegler, Constantine N. Tzouanas, Benjamin E. Mead, Alex M. Jaeger, Andrew W. Navia, Ryan P. King, Miyeko D. Mana, Siyi Huang, Vanessa Mitsialis, Scott B. Snapper, Ömer H. Yilmaz, Tyler Jacks, Jeffrey F. Van Humbeck, Alex K. Shalek
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Spatial transcriptomics aims to pair omic data with tissue structure. Here the authors report Spatially PhotoActivatable Colour Encoded Cell Address Tags (SPACECAT) to track and isolate live cells by location; this enables spatially informed downstre
Externí odkaz:
https://doaj.org/article/1dca5ab3f8864e5791c305a732202ce2
Autor:
Alexander Chye, Maree L. Hackett, Graeme J. Hankey, Erik Lundström, Osvaldo P. Almeida, John Gommans, Martin Dennis, Stephen Jan, Gillian E. Mead, Andrew H. Ford, Christopher Etherton Beer, Leon Flicker, Candice Delcourt, Laurent Billot, Craig S. Anderson, Katharina Stibrant Sunnerhagen, Qilong Yi, Severine Bompoint, Thang Huy Nguyen, Thomas Lung
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 16 (2022)
Background Function after acute stroke using the modified Rankin Scale (mRS) is usually assessed at a point in time. The analytical implications of serial mRS measurements to evaluate functional recovery over time is not completely understood. We com
Externí odkaz:
https://doaj.org/article/05a6e6764a87436e8b229383c9c59bf1
Autor:
Maria Augusta C. Horta, Jacob L. Steenwyk, Matthew E. Mead, Luciano H. Braz dos Santos, Shu Zhao, John G. Gibbons, Marina Marcet-Houben, Toni Gabaldón, Antonis Rokas, Gustavo H. Goldman
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Aspergillus fumigatus is both an environmental saprobe and an opportunistic human fungal pathogen. Knowledge of genomic variation across A. fumigatus isolates is essential for understanding the evolution of pathogenicity, virulence, and resi
Externí odkaz:
https://doaj.org/article/9ea2434ae19a49d588d2c08c020a125d
Publikováno v:
Frontiers in Fungal Biology, Vol 3 (2022)
Invasive aspergillosis is a deadly fungal disease; more than 400,000 patients are infected worldwide each year and the mortality rate can be as high as 50-95%. Of the ~450 species in the genus Aspergillus only a few are known to be clinically relevan
Externí odkaz:
https://doaj.org/article/bb9b0c4b3a3644a5a9611483b6f531cd
Autor:
Jakob Benedict Seidelin, Martin Iain Bahl, Tine Rask Licht, Benjamin E. Mead, Jeffrey M. Karp, Jens Vilstrup Johansen, Lene Buhl Riis, Marina Ramírez Galera, Anders Woetmann, Jacob Tveiten Bjerrum
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1281-1296 (2021)
Background and aims: The trigger hypothesis opens the possibility of anti-flare initiation therapies by stating that ulcerative colitis (UC) flares originate from inadequate responses to acute mucosal injuries. However, experimental evidence is restr
Externí odkaz:
https://doaj.org/article/4c66f520e857498a82ad966486d1bdad
Autor:
Jennifer Hall, Sarah Morton, Jessica Hall, David J. Clarke, Claire F. Fitzsimons, Coralie English, Anne Forster, Gillian E. Mead, Rebecca Lawton
Publikováno v:
Pilot and Feasibility Studies, Vol 6, Iss 1, Pp 1-13 (2020)
Abstract Background Stroke survivors are highly sedentary; thus, breaking up long uninterrupted bouts of sedentary behaviour could have substantial health benefit. However, there are no intervention strategies specifically aimed at reducing sedentary
Externí odkaz:
https://doaj.org/article/7f516f51370344e6a15e4d9a186e9411
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Treatment decision-making by family members on behalf of patients with major stroke can be challenging because of the shock of the diagnosis and lack of knowledge of the patient’s treatment preferences. We aimed to understand ho
Externí odkaz:
https://doaj.org/article/3fe7a67f12e34afc9ec5f67affd6b0aa
Autor:
Renato Augusto Corrêa dos Santos, Matthew E. Mead, Jacob L. Steenwyk, Olga Rivero-Menéndez, Ana Alastruey-Izquierdo, Gustavo Henrique Goldman, Antonis Rokas
Publikováno v:
Frontiers in Fungal Biology, Vol 2 (2021)
Certain Aspergillus fungi cause aspergillosis, a set of diseases that typically affect immunocompromised individuals. Most cases of aspergillosis are caused by Aspergillus fumigatus, which infects millions of people annually. Some closely related so-
Externí odkaz:
https://doaj.org/article/0d6fc54cae5b49f3bd9f3b48bec4050e