Zobrazeno 1 - 7
of 7
pro vyhledávání: '"P E, Losco"'
Autor:
B, Ballantyne, J C, Norris, D E, Dodd, D R, Klonne, P E, Losco, D A, Neptun, S C, Price, P, Grasso
Publikováno v:
Journal of applied toxicology : JAT. 17(4)
5-Ethylidene-2-norbornene (ENB) is an industrial chemical whose physical properties indicate a likelihood for vapor exposure to humans. The potential for target organ or cumulative toxicity was investigated in rats exposed for 6 h per day for 9 days
Publikováno v:
Veterinary and human toxicology. 37(1)
2-Ethyl-1,3-hexanediol (EHD; CASRN 94-96-2), an industrial chemical and insect repellent, has a high potential for recurrent skin contact. Short-term (9 d) and subchronic (13 w) repeated epicutaneous contact studies were conducted to determine the po
Autor:
P. E. Losco, J. M. Ward
Publikováno v:
Veterinary Pathology. 21:286-291
In the early stages of large granular lymphocyte leukemia of F344 rats, splenic congestion and lymphocytic depletion of the splenic white pulp are the most significant and consistent histologic findings. The diagnosis of early leukemia was confirmed
Publikováno v:
Drug and chemical toxicology. 12(1)
PEGs in the 3000 to 4000 MW range are used in many pharmaceutical and cosmetic applications; they produce little ocular or dermal irritation and have extremely low acute and subchronic toxicity by oral and dermal routes of administration. However, li
Autor:
P E, Losco, C M, Troup
Publikováno v:
Laboratory animal science. 38(6)
A spontaneous degenerative lesion of the cornea resembling calcific band keratopathy in man has been observed in 10-15% of the F-344 rats (aged 35-300 days) purchased from a private vendor's closed breeding colony. The lesion appears clinically as pu
Autor:
P. E. Losco
Publikováno v:
Veterinary pathology. 23(4)
Publikováno v:
Veterinary and human toxicology. 30(2)
1-Propoxy-2-propanol, a widely used industrial chemical, was found to have acute peroral LD50 values in the rat of 4.92 ml/kg (males) and 2.83 ml/kg (females), with the signs of systemic toxicity being principally related to narcosis. Acute percutane