Zobrazeno 1 - 7
of 7
pro vyhledávání: '"P E, Genereux"'
Publikováno v:
Diabetes. 47:179-185
The aim of this study was to compare the effects of insulin and the insulinomimetic agent, englitazone, on functional end points and putative mediators of insulin action in 3T3-L1 adipocytes. Cells were incubated with englitazone for 48 h or with ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a2465d9940a1f277538f52141e5711
https://doi.org/10.2337/diabetes.47.2.179
https://doi.org/10.2337/diabetes.47.2.179
Autor:
R W Stevenson, J Spitzer, A G Swick, P. E. Genereux, K. M. Andrews, J J Herbst, R K McPherson, L M Persson, David K. Kreutter, E. M. Gibbs
Publikováno v:
Diabetes. 45:60-66
The effects of englitazone in male Wistar rats fed a high-fat diet (59% of calories as fat) were compared with control rats fed a high-carbohydrate diet (69% of calories as carbohydrate) (5–15 animals per group). Insulin-stimulated (17 nmol/l) 2-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b016a6f1f2956597a68c3bd521265e3d
https://doi.org/10.2337/diabetes.45.1.60
https://doi.org/10.2337/diabetes.45.1.60
Publikováno v:
Journal of Medicinal Chemistry. 39:3897-3907
The thiazolidinedione moiety of ciglitazone and its analogues can be replaced by an alpha-alkoxy or alpha-thioether carboxylic acid group. The influence of the nature of the R group, the length of the connector to the aromatic backbone of the molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de21c98b4e105c782b96ed9610a37f9
https://doi.org/10.1021/jm960230h
https://doi.org/10.1021/jm960230h
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e5d71bdb6e02619565758e036dde532
https://doi.org/10.1002/chin.199704139
https://doi.org/10.1002/chin.199704139
Publikováno v:
Pharmaceutical Research. 13:1585-1587
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::178524165c9d5949d3685639f9e1216b
https://doi.org/10.1023/a:1016004318459
https://doi.org/10.1023/a:1016004318459
Publikováno v:
Pharmaceutical research. 13(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::484f1ad8e51a9c2910f25e4f73bdf932
https://pubmed.ncbi.nlm.nih.gov/8899856
https://pubmed.ncbi.nlm.nih.gov/8899856
Autor:
Gustav E. Lienhard, J J Herbst, E M Gibbs, David H. Singleton, P E Genereux, Leonard G. Contillo, Glenn C. Andrews
Publikováno v:
The Journal of biological chemistry. 270(43)
Insulin causes the activation of phosphatidylinositol 3-kinase (PI 3-kinase) through complexation of tyrosine-phosphorylated YMXM motifs on insulin receptor substrate 1 with the Src homology 2 domains of PI 3-kinase. Previous studies with inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d5fa844b7157ccad66fe5579bf3cc3
https://pubmed.ncbi.nlm.nih.gov/7592791
https://pubmed.ncbi.nlm.nih.gov/7592791