Zobrazeno 1 - 10
of 16
pro vyhledávání: '"P E, Ganey"'
Autor:
Jeffrey F. Waring, Patricia E. Ganey, Robert A. Roth, Eric A. G. Blomme, David M. Nelson, Amy C. Ditewig, Jane F. Maddox, James P. Luyendyk, Lois D. Lehman-McKeeman, Vasanthi M. Bhaskaran, Michael J. Liguori
Publikováno v:
International Journal of Molecular Sciences, Vol 11, Iss 11, Pp 4697-4714 (2010)
Idiosyncratic drug reactions (IDRs) are poorly understood, unpredictable, and not detected in preclinical studies. Although the cause of these reactions is likely multi-factorial, one hypothesis is that an underlying inflammatory state lowers the tol
Externí odkaz:
https://doaj.org/article/cd16481e4a9f4fe5ad6ba562b8b8db9a
Publikováno v:
Toxicology and Applied Pharmacology. 131:136-143
Exposure in vitro to the mixture of polychlorinated biphenyls (PCBs), Aroclor 1242, stimulates superoxide anion (O2-) production and degranulation in rat polymorphonuclear neutrophils (PMNs). The mechanism by which PCBs activate PMNs is unknown. Phos
Publikováno v:
Circulation Research. 68:1610-1613
The purpose of these studies was to test whether O2 tension influences cardiotoxicity due to doxorubicin. Isolated hearts were perfused by the method of Langendorff at constant pressure with Krebs-Henseleit buffer saturated with 5% CO2 and either 95%
Autor:
J, Olivero, P E, Ganey
Publikováno v:
Biochemical pharmacology. 62(8)
The effects of Ca2+ and Ca2+/calmodulin on the polychlorinated biphenyl (PCB)-induced activation of phospholipase A2 (PLA2) in rat neutrophils were examined. The commercial PCB mixture Aroclor 1242 induced activation of PLA2 and promoted an increase
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(2)
Arachidonic acid (AA) released from membrane phospholipids by phospholipase A2 (PLA2) is important as a substrate for eicosanoid formation and as a second messenger for superoxide anion (O2-) generation in neutrophils. Different isoforms of PLA2 in n
Publikováno v:
Biochemical pharmacology. 53(8)
When activated, inflammatory cells such as polymorphonuclear leukocytes (PMNs) can damage isolated hepatocytes in vitro. These studies were performed to determine if flutamide activates PMNs. Flutamide (Eulexin) is an orally active, nonsteroidal anti
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 70(1)
Activated neutrophils (PMNs) release cytotoxic agents that can damage surrounding tissue. These studies were performed to determine whether activated PMNs from rat could injure isolated, rat hepatic parenchymal cells (HCs) in vitro.HCs were coculture
Autor:
P E, Ganey, R G, Thurman
Publikováno v:
Cancer research. 51(8)
Doxorubicin is an antineoplastic drug which undergoes oxidation-reduction cycling and produces toxicity to some cancer cell lines. Since oxidation-reduction cycling requires reducing equivalents and because ethanol metabolism via alcohol dehydrogenas
Publikováno v:
Hepatology (Baltimore, Md.). 13(3)
A new method was developed to monitor Kupffer cell phagocytosis continuously in perfused liver using a fluorescent probe, rhodamine-gelatin, synthesized from gelatin and rhodamine isothiocyanate. In perfused rat liver, phagocytosis by Kupffer cells w
Publikováno v:
Molecular pharmacology. 38(6)
Menadione bisulfite is a hepatotoxicant that damages periportal regions of the lobule in perfused liver in an oxygen-dependent manner. The effect of ethanol on menadione bisulfite toxicity was examined in perfused rat liver. Addition of menadione bis