Zobrazeno 1 - 10
of 54
pro vyhledávání: '"P E, Castle"'
Somatic mutations in 3929 HPV positive cervical cells associated with infection outcome and HPV type
Autor:
Maisa Pinheiro, Nicolas Wentzensen, Michael Dean, Meredith Yeager, Zigui Chen, Amulya Shastry, Joseph F. Boland, Sara Bass, Laurie Burdett, Thomas Lorey, Sambit Mishra, Philip E. Castle, Mark Schiffman, Robert D. Burk, Bin Zhu, Lisa Mirabello
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Invasive cervical cancers (ICC), caused by HPV infections, have a heterogeneous molecular landscape. We investigate the detection, timing, and HPV type specificity of somatic mutations in 3929 HPV-positive exfoliated cervical cell samples fr
Externí odkaz:
https://doaj.org/article/c1bcd6c690174c39b5a8206f244b5eba
Autor:
Gad Murenzi, Edda Vuhahula, Asteria Kimambo, Subira Matiku, Obed Tuyishime, Edwin Liwa, Thomas Habanabakize, Eulade Rugengamanzi, Atuganile Malango, Gallican Kubwimana, Kathryn Anastos, Philip E. Castle
Publikováno v:
Infectious Agents and Cancer, Vol 19, Iss 1, Pp 1-9 (2024)
Abstract Background High-risk human papillomavirus (hrHPV) infection causes almost all cervical cancer. Women living with human immunodeficiency virus (Women living with HIV: WLWHIV) are at a six-fold increased risk of developing cervical cancer. Thi
Externí odkaz:
https://doaj.org/article/723b5da42d1042fa99e35c58d0c9c54e
Autor:
Megan E. Castle, Meghan E. Flanigan
Publikováno v:
Neurobiology of Stress, Vol 30, Iss , Pp 100618- (2024)
Alcohol Use Disorder (AUD) is a leading cause of death and disability worldwide, but current treatments are insufficient in fully addressing the symptoms that often lead to relapses in alcohol consumption. The brain's serotonin system has been implic
Externí odkaz:
https://doaj.org/article/b169fbc8a3f14bbe81ca761affdd8031
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)
Invasive cancers typically evade immune surveillance through profound local and systemic immunosuppression, preventing their elimination or control. Targeting immune interventions to prevent or intercept premalignant lesions, before significant immun
Externí odkaz:
https://doaj.org/article/5523cedbde864175bf9911b2612425bf
Autor:
Megan M. Chang, Ariel Ma, Emilie Newsham Novak, Maria Barra, Kathryn A. Kundrod, Jane Richards Montealegre, Michael E. Scheurer, Philip E. Castle, Kathleen Schmeler, Rebecca Richards-Kortum
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Cervical cancer is a leading cause of death for women in low-resource settings despite being preventable through human papillomavirus (HPV) vaccination, early detection, and treatment of precancerous lesions. The World Health Organization re
Externí odkaz:
https://doaj.org/article/99092a73ebd440dfb40715212f927462
Autor:
Philip E. Castle
Publikováno v:
Viruses, Vol 16, Iss 9, p 1357 (2024)
Despite the introduction of Pap testing for screening to prevent cervical cancer in the mid-20th century, cervical cancer remains a common cause of cancer-related mortality and morbidity globally. This is primarily due to differences in access to scr
Externí odkaz:
https://doaj.org/article/ff1fef35d9f3431cb6dd44c7b6ef5578
Autor:
Samantha Batman, Ricardina Rangeiro, Eliane Monteiro, Dercia Changule, Siro Daud, Magda Ribeiro, Edgar Tsambe, Celso Bila, Nafissa Osman, Carla Carrilho, Andrea Neves, Hira Atif, Celda De Jesus, Arlete Mariano, Renato Moretti-Marques, Marcelo Vieira, Georgia Fontes-Cintra, Andre Lopes, Jean Claude Batware, Elvira Luis, Surbhi Grover, Ellen Baker, Bryan Fellman, Jane Montealegre, Philip E. Castle, Jose Jeronimo, Elizabeth Chiao, Cesaltina Lorenzoni, Kathleen Schmeler, Mila P. Salcedo
Publikováno v:
JCO Global Oncology, Vol , Iss 9 (2023)
PURPOSEMozambique has one of the highest burdens of cervical cancer globally. Treatment options are few as most women present with advanced disease, and there are limited trained health professionals and health care resources. The objective of this s
Externí odkaz:
https://doaj.org/article/7cb17a413e4746d3be9a5ebc3c182027
Autor:
Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon, Anna-Barbara Moscicki, Richard M. Novak, Mickey V. Patel, Intira Sriprasert, Andrea R. Thurman, Sergey Yegorov, Nelly Rwamba Mugo, Alison C. Roxby, Elizabeth Micks, Florian Hladik, The Consortium for Assessing Immunity Across the Menstrual Cycle
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-32 (2022)
Abstract Background Hormonal changes during the menstrual cycle play a key role in shaping immunity in the cervicovaginal tract. Cervicovaginal fluid contains cytokines, chemokines, immunoglobulins, and other immune mediators. Many studies have shown
Externí odkaz:
https://doaj.org/article/6aca5fc4f96043c18149881f3f0a4745
Autor:
Louiza S. Velentzis, David Hawkes, Michael Caruana, Julia ML. Brotherton, Megan A. Smith, Lara Roeske, Khurram A. Karim, Suzanne M. Garland, C. David Wrede, Jeffery Tan, Cosette Wheeler, Philip E. Castle, Marion Saville, Karen Canfell
Publikováno v:
Tumour Virus Research, Vol 15, Iss , Pp 200255- (2023)
Australia's cervical screening program transitioned from cytology to HPV-testing with genotyping for HPV16/18 in Dec’2017. We investigated whether program data could be used to monitor HPV vaccination program impact (commenced in 2007) on HPV16/18
Externí odkaz:
https://doaj.org/article/b14dd6b43e0b4bb8a9aa153c7078c67d
Publikováno v:
Environmental Evidence, Vol 11, Iss 1, Pp 1-27 (2022)
Abstract Background Agroforestry bridges the gap that often separates agriculture and forestry by building integrated systems to address both environmental and socio-economic objectives. Existing empirical research has suggested that agroforestry—t
Externí odkaz:
https://doaj.org/article/b06f3ca98de34774ae5725f6635b89a1