Zobrazeno 1 - 10
of 164
pro vyhledávání: '"P Darrell Neufer"'
Autor:
Yan Tang, Haihong Zong, Hyokjoon Kwon, Yunping Qiu, Jacob B Pessin, Licheng Wu, Katherine A Buddo, Ilya Boykov, Cameron A Schmidt, Chien-Te Lin, P Darrell Neufer, Gary J Schwartz, Irwin J Kurland, Jeffrey E Pessin
Publikováno v:
eLife, Vol 11 (2022)
Cholinergic and sympathetic counter-regulatory networks control numerous physiological functions, including learning/memory/cognition, stress responsiveness, blood pressure, heart rate, and energy balance. As neurons primarily utilize glucose as thei
Externí odkaz:
https://doaj.org/article/e95994c3aa1f45b29619ac86493dbd58
Autor:
Margaret AM Nelson, Kelsey L McLaughlin, James T Hagen, Hannah S Coalson, Cameron Schmidt, Miki Kassai, Kimberly A Kew, Joseph M McClung, P Darrell Neufer, Patricia Brophy, Nasreen A Vohra, Darla Liles, Myles C Cabot, Kelsey H Fisher-Wellman
Publikováno v:
eLife, Vol 10 (2021)
Currently there is great interest in targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer. However, notwithstanding the targeting of mutant dehydrogenases, nearly all hopeful ‘mito-therapeutics’ cannot discriminate cancerous from
Externí odkaz:
https://doaj.org/article/e567853a8a3040149b87851b0c1938d3
Autor:
Daniel S Lark, Li Kang, Mary E Lustig, Jeffrey S Bonner, Freyja D James, P Darrell Neufer, David H Wasserman
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126732 (2015)
Improving mitochondrial oxidant scavenging may be a viable strategy for the treatment of insulin resistance and diabetes. Mice overexpressing the mitochondrial matrix isoform of superoxide dismutase (sod2(tg) mice) and/or transgenically expressing ca
Externí odkaz:
https://doaj.org/article/f55d0c6761ed461ba18256351c6b0304
Autor:
Filip Jevtovic, Donghai Zheng, Alex Claiborne, Ericka M. Biagioni, Breanna L. Wisseman, Polina M. Krassovskaia, David N. Collier, Christy Isler, James E. DeVente, P. Darrell Neufer, Joseph A. Houmard, Linda E. May
Publikováno v:
Physiological Reports, Vol 12, Iss 9, Pp n/a-n/a (2024)
Abstract Maternal exercise (ME) has been established as a useful non‐pharmacological intervention to improve infant metabolic health; however, mechanistic insight behind these adaptations remains mostly confined to animal models. Infant mesenchymal
Externí odkaz:
https://doaj.org/article/aa0485e37ae942f0ae76a79ecd06da11
Autor:
Anandita Pal, Chien-Te Lin, Ilya Boykov, Emily Benson, Grahame Kidd, Kelsey H. Fisher-Wellman, P. Darrell Neufer, Saame Raza Shaikh
Publikováno v:
Nutrients, Vol 15, Iss 22, p 4807 (2023)
Diet-induced obesity impairs mitochondrial respiratory responses in tissues that are highly metabolically active, such as the heart. However, less is known about the impact of obesity on the respiratory activity of specific cell types, such as spleni
Externí odkaz:
https://doaj.org/article/47547dcca042488fbe739c06c633524c
Autor:
Kelsey H. Fisher-Wellman, Miki Kassai, James T. Hagen, P. Darrell Neufer, Mark Kester, Thomas P. Loughran, Charles E. Chalfant, David J. Feith, Su-Fern Tan, Todd E. Fox, Johnson Ung, Gemma Fabrias, Jose’ Luis Abad, Arati Sharma, Upendarrao Golla, David F. Claxton, Jeremy J. P. Shaw, Debajit Bhowmick, Myles C. Cabot
Publikováno v:
Cancers, Vol 15, Iss 6, p 1883 (2023)
Acute myelogenous leukemia (AML), the most prevalent acute and aggressive leukemia diagnosed in adults, often recurs as a difficult-to-treat, chemotherapy-resistant disease. Because chemotherapy resistance is a major obstacle to successful treatment,
Externí odkaz:
https://doaj.org/article/ca6bd77bb8654ba79e7f98395933d8b2
Autor:
Cameron A. Schmidt, Kelsey L. McLaughlin, Ilya N. Boykov, Rafiq Mojalagbe, Arthi Ranganathan, Katherine A. Buddo, Chien-Te Lin, Kelsey H. Fisher-Wellman, P. Darrell Neufer
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-21 (2021)
Abstract Background Hepatocellular carcinoma (HCC) is the most prevalent form of liver malignancy and carries poor prognoses due to late presentation of symptoms. Treatment of late-stage HCC relies heavily on chemotherapeutics, many of which target c
Externí odkaz:
https://doaj.org/article/382472ad818642f186cfad27147e39e6
Autor:
Melissa R. Iñigo, Adam J. Amorese, Michael D. Tarpey, Nicholas P. Balestrieri, Keith G. Jones, Daniel J. Patteson, Kathryn C. Jackson, Maria.J. Torres, Chien-Te Lin, Cody D. Smith, Timothy D. Heden, Shawna L. McMillin, Luke A. Weyrauch, Erin C. Stanley, Cameron A. Schmidt, Brita B. Kilburg-Basnyat, Sky W. Reece, Christine E. Psaltis, Leslie A. Leinwand, Katsu Funai, Joseph M. McClung, Kymberly M. Gowdy, Carol A. Witczak, Dawn A. Lowe, P. Darrell Neufer, Espen E. Spangenburg
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 1-15 (2020)
Objective: Estrogen receptor-α (ERα) is a nuclear receptor family member thought to substantially contribute to the metabolic regulation of skeletal muscle. However, previous mouse models utilized to assess the necessity of ERα signaling in skelet
Externí odkaz:
https://doaj.org/article/cef6092a71cd44739e7411b85eb621c4
Autor:
Jordan M. Johnson, Anthony R.P. Verkerke, J. Alan Maschek, Patrick J. Ferrara, Chien-Te Lin, Kimberly A. Kew, P. Darrell Neufer, Irfan J. Lodhi, James E. Cox, Katsuhiko Funai
Publikováno v:
Molecular Metabolism, Vol 31, Iss , Pp 55-66 (2020)
Objective: Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis. Mice lacking PEMT (PEMTKO) are co
Externí odkaz:
https://doaj.org/article/18dd0661e3eb419f9648dcc98c3e8fc2
Autor:
Terence E. Ryan, Cameron A. Schmidt, Michael D. Tarpey, Adam J. Amorese, Dean J. Yamaguchi, Emma J. Goldberg, Melissa M.R. Iñigo, Reema Karnekar, Allison O’Rourke, James M. Ervasti, Patricia Brophy, Thomas D. Green, P. Darrell Neufer, Kelsey Fisher-Wellman, Espen E. Spangenburg, Joseph M. McClung
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
Compromised muscle mitochondrial metabolism is a hallmark of peripheral arterial disease, especially in patients with the most severe clinical manifestation — critical limb ischemia (CLI). We asked whether inflexibility in metabolism is critical fo
Externí odkaz:
https://doaj.org/article/ae9840111eff4cc6b769461964faa51a