Treatment with galectin-1 improves myogenic potential and membrane repair in dysferlin-deficient models.

Autor: Mary L Vallecillo-Zúniga, Matthew F Rathgeber, P Daniel Poulson, Spencer Hayes, Jacob S Luddington, Hailie N Gill, Matthew Teynor, Braden C Kartchner, Jonard Valdoz, Caleb Stowell, Ashley R Markham, Connie Arthur, Sean Stowell, Pam M Van Ry

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0238441 (2020)

Limb-girdle muscular dystrophy type 2B (LGMD2B) is caused by mutations in the dysferlin gene, resulting in non-functional dysferlin, a key protein found in muscle membrane. Treatment options available for patients are chiefly palliative in nature and

Externí odkaz: https://doaj.org/article/1b0d5091b3e842558ddcb01bd5b3fcc0

CEBPA Overexpression Enhances β-Cell Proliferation and Survival

Autor: Peter N. Ellsworth, Jacob A. Herring, Aaron H. Leifer, Jason D. Ray, Weston S. Elison, Peter Daniel Poulson, Jacqueline E. Crabtree, Pam M. Van Ry, Jeffery S. Tessem

Publikováno v: Biology, Vol 13, Iss 2, p 110 (2024)

A commonality between type 1 and type 2 diabetes is the decline in functional β-cell mass. The transcription factor Nkx6.1 regulates β-cell development and is integral for proper β-cell function. We have previously demonstrated that Nkx6.1 depends

Externí odkaz: https://doaj.org/article/acccf53dc7734d41840047ae1c3c5757

Soluble ECM promotes organotypic formation in lung alveolar model

Autor: Jonard C. Valdoz, Nicholas A. Franks, Collin G. Cribbs, Dallin J. Jacobs, Ethan L. Dodson, Connor J. Knight, P. Daniel Poulson, Seth R. Garfield, Benjamin C. Johnson, Brandon M. Hemeyer, Miranda T. Sudo, Jordan A. Saunooke, Braden C. Kartchner, Aubrianna Saxton, Mary L. Vallecillo-Zuniga, Matheus Santos, Brandon Chamberlain, Kenneth A. Christensen, Greg P. Nordin, A. Sampath Narayanan, Ganesh Raghu, Pam M. Van Ry

Publikováno v: Biomaterials

Micropatterned suspension culture creates consistently sized and shaped cell aggregates but has not produced organotypic structures from stable cells, thus restricting its use in accurate disease modeling. Here, we show that organotypic structure is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8f878078bbde231aa8fa8b933bba8e
https://doi.org/10.1101/2021.09.16.460165

Spatially and optically tailored 3D printing for highly miniaturized and integrated microfluidics

Autor: Jose L. Sanchez Noriega, Nicholas A. Chartrand, Jonard Corpuz Valdoz, Collin G. Cribbs, Dallin A. Jacobs, Daniel Poulson, Matthew S. Viglione, Adam T. Woolley, Pam M. Van Ry, Kenneth A. Christensen, Gregory P. Nordin

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

The ever-growing need for highly functional, compact, and integrated microfluidic devices often incurs lengthy and expensive manufacturing processes. Here, authors introduce a generalized 3D printing process that enables fast parallel fabrication of

Externí odkaz: https://doaj.org/article/b99f1488a268491db2c0a7428bb4835d

De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8.

Autor: Roy A; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Shi L; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Current Address: Encodia Inc, 5785 Oberlin Drive, San Diego, CA 92121., Chang A; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Dong X; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, United States.; Current address: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China; Engineering Research Center of Protein and Peptide Medicine，Ministry of Education., Fernandez A; Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Kraft JC; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Li J; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, United States., Le VQ; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, United States., Winegar RV; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Cherf GM; Department of Bioengineering, Stanford University, Stanford CA 94305.; Current Address: Denali Therapeutics, South San Francisco, CA, USA., Slocum D; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Daniel Poulson P; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Casper GE; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Vallecillo-Zúniga ML; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Valdoz JC; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Miranda MC; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Current Address: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden., Bai H; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Kipnis Y; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington., Olshefsky A; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Priya T; Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.; Current Address: Department of Pharmacology, Northwestern University Feinberg School of Medicine; Chicago, IL 60611, USA., Carter L; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Ravichandran R; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Chow CM; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Johnson MR; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Cheng S; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Smith M; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Overed-Sayer C; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.; Current Address: Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Finch DK; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.; Current Address: Alchemab Therapeutics Ltd, Cambridge, United Kingdom., Lowe D; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.; Current Address: Evox Therapeutics Limited, Oxford Science Park, Medawar Centre, East Building, Robert Robinson Avenue, Oxford, OX4 4HG., Bera AK; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Matute-Bello G; Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington., Birkland TP; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington., DiMaio F; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Raghu G; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington., Cochran JR; Department of Bioengineering, Stanford University, Stanford CA 94305., Stewart LJ; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Campbell MG; Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Van Ry PM; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA., Springer T; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, United States., Baker D; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 12. Date of Electronic Publication: 2023 Jun 12.