Zobrazeno 1 - 10
of 24
pro vyhledávání: '"P D, Roepe"'
Autor:
Laura M. Hagenah, Satish K. Dhingra, Jennifer L. Small-Saunders, Tarrick Qahash, Andreas Willems, Kyra A. Schindler, Gabriel W. Rangel, Eva Gil-Iturbe, Jonathan Kim, Emiliya Akhundova, Tomas Yeo, John Okombo, Filippo Mancia, Matthias Quick, Paul D. Roepe, Manuel Llinás, David A. Fidock
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTMalaria elimination efforts in Southeast Asia have been hindered by multidrug-resistant Plasmodium falciparum. High-grade resistance to piperaquine (PPQ, used in combination with dihydroartemisinin) is associated with PfCRT mutations that aro
Externí odkaz:
https://doaj.org/article/ccd09ec4400a4cee8b8849d9566f3a45
Autor:
Jennifer L Small-Saunders, Laura M Hagenah, Kathryn J Wicht, Satish K Dhingra, Ioanna Deni, Jonathan Kim, Jeremie Vendome, Eva Gil-Iturbe, Paul D Roepe, Monica Mehta, Filippo Mancia, Matthias Quick, Margaret J Eppstein, David A Fidock
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010278 (2022)
Multidrug-resistant Plasmodium falciparum parasites have emerged in Cambodia and neighboring countries in Southeast Asia, compromising the efficacy of first-line antimalarial combinations. Dihydroartemisinin + piperaquine (PPQ) treatment failure rate
Externí odkaz:
https://doaj.org/article/c0f2898adda746c4b1fca32595599be4
Autor:
Matthew R Hassett, Paul D Roepe
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248057 (2021)
Over the past decade, artemisinin (ART)-combination therapies (ACTs) have shown declining efficacy within Southeast Asia (SEA). These resistance-like phenomena manifest as a delayed clearance phenotype (DCP) in some patients treated with ACTs. ACTs a
Externí odkaz:
https://doaj.org/article/d9cf16fad6744ce5892126ef88e65c08
Autor:
L Brock Thornton, Paige Teehan, Katherine Floyd, Christian Cochrane, Amy Bergmann, Bryce Riegel, Andrew J Stasic, Manlio Di Cristina, Silvia N J Moreno, Paul D Roepe, Zhicheng Dou
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007775 (2019)
Toxoplasma gondii is an apicomplexan parasite with the ability to use foodborne, zoonotic, and congenital routes of transmission that causes severe disease in immunocompromised patients. The parasites harbor a lysosome-like organelle, termed the "Vac
Externí odkaz:
https://doaj.org/article/ca1b5446d52a4e478bf5f179c57051c4
Autor:
Laura E. Heller, Paul D. Roepe
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 4, Iss 2, p 89 (2019)
The molecular pharmacology of artemisinin (ART)-based antimalarial drugs is incompletely understood. Clinically, these drugs are used in combination with longer lasting partner drugs in several different artemisinin combination therapies (ACTs). ACTs
Externí odkaz:
https://doaj.org/article/928a738db2784e519268195ed6018c51
Autor:
Stanislaw J Gabryszewski, Satish K Dhingra, Jill M Combrinck, Ian A Lewis, Paul S Callaghan, Matthew R Hassett, Amila Siriwardana, Philipp P Henrich, Andrew H Lee, Nina F Gnädig, Lise Musset, Manuel Llinás, Timothy J Egan, Paul D Roepe, David A Fidock
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005976 (2016)
Southeast Asia is an epicenter of multidrug-resistant Plasmodium falciparum strains. Selective pressures on the subcontinent have recurrently produced several allelic variants of parasite drug resistance genes, including the P. falciparum chloroquine
Externí odkaz:
https://doaj.org/article/bab670c229784bbdbbf53c730e617d2b
Autor:
John O. Suberu, Alexander P. Gorka, Lauren Jacobs, Paul D. Roepe, Neil Sullivan, Guy C. Barker, Alexei A. Lapkin
Publikováno v:
PLoS ONE, Vol 8, Iss 11 (2013)
Externí odkaz:
https://doaj.org/article/ffbd770964c84a169d7547c8746ba12c
Autor:
John O Suberu, Alexander P Gorka, Lauren Jacobs, Paul D Roepe, Neil Sullivan, Guy C Barker, Alexei A Lapkin
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80790 (2013)
Artemisia annua hot water infusion (tea) has been used in in vitro experiments against P. falciparum malaria parasites to test potency relative to equivalent pure artemisinin. High performance liquid chromatography (HPLC) and mass spectrometric analy
Externí odkaz:
https://doaj.org/article/840410d0d1e8431c913375c68cfe8712
Autor:
David Gaviria, Michelle F Paguio, Lindsey B Turnbull, Asako Tan, Amila Siriwardana, Debasish Ghosh, Michael T Ferdig, Anthony P Sinai, Paul D Roepe
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79059 (2013)
Resistance to the cytostatic activity of the antimalarial drug chloroquine (CQ) is becoming well understood, however, resistance to cytocidal effects of CQ is largely unexplored. We find that PfCRT mutations that almost fully recapitulate P. falcipar
Externí odkaz:
https://doaj.org/article/a6aa121832ba48ff8477d05a625588db
Publikováno v:
The Journal of General Physiology
Multidrug resistance (MDR) mediated by overexpression of the MDR protein (P-glycoprotein) has been associated with intracellular alkalinization, membrane depolarization, and other cellular alterations. However, virtually all MDR cell lines studied in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c10e9dc7c4c464d4efe2537d2d26706
https://doi.org/10.1085/jgp.108.4.295
https://doi.org/10.1085/jgp.108.4.295