Zobrazeno 1 - 10
of 14
pro vyhledávání: '"P D, Monk"'
Autor:
Phillip D. Monk, Jody L. Brookes, Victoria J. Tear, Toby N. Batten, Clare Newall, Marcin Mankowski, Michael G. Crooks, Dave Singh, Rekha Chaudhuri, Brian Leaker, Kerry Lunn, Sophie Reynolds, Sarah Dudley, Felicity J. Gabbay, Stephen T. Holgate, Ratko Djukanovic, Thomas MA Wilkinson
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Respiratory viral infections are major drivers of chronic obstructive pulmonary disease (COPD) exacerbations. Interferon-β is naturally produced in response to viral infection, limiting replication. This exploratory study aimed t
Externí odkaz:
https://doaj.org/article/0e45758b1a514217839b388bd5252764
Autor:
Joseph A. Bell, Elizabeth R. Davies, Christopher J. Brereton, Milica Vukmirovic, James J.W. Roberts, Kerry Lunn, Leanne Wickens, Franco Conforti, Robert A. Ridley, Jessica Ceccato, Lucy N. Sayer, David A. Johnston, Andres F. Vallejo, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, Aurelie Fabre, Luca Richeldi, Phillip D. Monk, Paul Skipp, Naftali Kaminski, Emily Offer, Yihua Wang, Donna E. Davies, Mark G. Jones
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101695- (2024)
Summary: Matrix stiffening by lysyl oxidase-like 2 (LOXL2)-mediated collagen cross-linking is proposed as a core feedforward mechanism that promotes fibrogenesis. Failure in clinical trials of simtuzumab (the humanized version of AB0023, a monoclonal
Externí odkaz:
https://doaj.org/article/28bf070de21f4af1b6319da757012509
Publikováno v:
Radiation, Vol 3, Iss 4, Pp 211-225 (2023)
Nuclear sites require regular measurements of the air, soil, and groundwater to ensure the safety of the surrounding environment from potentially hazardous levels of contamination. Although high-energy beta and gamma emitters can often be detected in
Externí odkaz:
https://doaj.org/article/d6b73a145ebe41549ba1416a1f0ad2b9
Autor:
Nick A Francis, Phillip D Monk, Jacqueline Nuttall, Thomas Oliver, Catherine Simpson, Jody L Brookes, Victoria J Tear, Angela G Thompson, Toby N Batten, Marcin Mankowski, Thomas MA Wilkinson
Publikováno v:
BJGP Open, Vol 7, Iss 4 (2023)
Background: Effective therapeutics given early to high-risk ambulatory patients with coronavirus disease 2019 (COVID-19) could improve outcomes and reduce overall healthcare burden. However, conducting site visits in non-hospitalised patients, who sh
Externí odkaz:
https://doaj.org/article/ce250c5f637c4c0a8fc6392c28c1c035
Autor:
Prasanna Jagannathan, Kara W. Chew, Mark J. Giganti, Michael D. Hughes, Carlee Moser, Mark J. Main, Phillip D. Monk, Arzhang Cyrus Javan, Jonathan Z. Li, Courtney V. Fletcher, Caitlyn McCarthy, David A. Wohl, Eric S. Daar, Joseph J. Eron, Judith S. Currier, Upinder Singh, Davey M. Smith, William Fischer, Kara Chew, David (Davey) Smith, Eric Daar, David Wohl, Judith Currier, Joseph Eron, Michael Hughes, Mark Giganti, Justin Ritz, Lara Hosey, Jhoanna Roa, Nilam Patel, Kelly Colsh, Irene Rwakazina, Justine Beck, Scott Sieg, Jonathan Li, Courtney Fletcher, Teresa Evering, Rachel Bender Ignacio, Sandra Cardoso, Katya Corado, Nikolaus Jilg, Alan Perelson, Sandy Pillay, Cynthia Riviere, Babafemi Taiwo, Joan Gottesman, Matthew Newell, Susan Pedersen, Joan Dragavon, Cheryl Jennings, Brian Greenfelder, William Murtaugh, Jan Kosmyna, Morgan Gapara, Akbar Shahkolahi, Gerald Pierone, Juliana Elliott, Jeffrey Jacobson, Leila Hojat, Julie Pasternak, Jonathan Berardi, Celine Arar, Yevgeniy Bukhman, Manish Jain, Eugene Bukhman, Sadia Shaik, Timothy Hatlen, Kelly Dooley, Becky Becker, Adaliah Wilkins, Jose Pérez, Eloy Roman, Heriberto Fernández, Keila Hoover, James Renfroe, Mauney Weldon, Genei Bougher, Carlos Malvestutto, Heather Harber, Robyn Cicarella, Gene Neytman, Jack Herman, Craig Herman, Mariam Aziz, Joan Swiatek, Divya Pathak, Madhu Choudhary, Jennifer Sullivano, Olayemi Osiyemi, Myriam Izquierdo, Odelsey Torna, Aleen Khodabakhshian, Samantha Fortier, Constance Benson, Steven Hendrickx, Rosemarie Ramirez, Anne Luetkemeyer, Suzanne Hendler, Dennis Dentoni-Lasofsky, Mario Castro, Leslie Spikes, Chase Hall, Jonathan Oakes, Amy James Loftis, Pablo Tebas, William Short, Sarah McGuffin, Chris Jonsson, Rachel Presti, Alem Haile
Publikováno v:
EClinicalMedicine, Vol 65, Iss , Pp 102250- (2023)
Summary: Background: With the emergence of SARS-CoV-2 variants resistant to monoclonal antibody therapies and limited global access to therapeutics, the evaluation of novel therapeutics to prevent progression to severe COVID-19 remains a critical nee
Externí odkaz:
https://doaj.org/article/454735c4a8b341a688fdabe4d9bc0450
Autor:
Phillip D. Monk, Jody L. Brookes, Victoria J. Tear, Toby N. Batten, Marcin Mankowski, Tatjana Adzic-Vukicevic, Michael G. Crooks, Davinder P.S. Dosanjh, Monica Kraft, Christopher E. Brightling, Felicity J. Gabbay, Stephen T. Holgate, Ratko Djukanovic, Tom M.A. Wilkinson
Publikováno v:
ERJ Open Research, Vol 9, Iss 2 (2023)
Background Despite the availability of vaccines and therapies, patients are being hospitalised with coronavirus disease 2019 (COVID-19). Interferon (IFN)-β is a naturally occurring protein that stimulates host immune responses against most viruses,
Externí odkaz:
https://doaj.org/article/59ef7b2928b0495c936fac3cc3b5d606
Autor:
Tomas Fried, Antonio Di Buono, David Cheneler, Neil Cockbain, Jonathan M. Dodds, Peter R. Green, Barry Lennox, C. James Taylor, Stephen D. Monk
Publikováno v:
Nuclear Engineering and Technology, Vol 53, Iss 10, Pp 3335-3343 (2021)
The impact of gamma radiation on a commercial off the shelf microcontroller board has been investigated. Three different tests have been performed to ascertain the radiation tolerance of the device from a nuclear decommissioning deployment perspectiv
Externí odkaz:
https://doaj.org/article/17c8dad9c3d445bd857396074b8d6a2d
Publikováno v:
Sensors, Vol 23, Iss 8, p 4053 (2023)
A compact back-end interface for silicon photomultipliers (SiPMs) implementing Zener diode-based temperature compensation has been developed for the remote detection of beta and gamma radiation. Remote detection is facilitated by the development of a
Externí odkaz:
https://doaj.org/article/3f9b4323d393426c9f945e6fee83061b
Autor:
Stephen D. Monk, Alex Grievson, Manuel Bandala, Craig West, Allahyar Montazeri, C. James Taylor
Publikováno v:
Robotics, Vol 10, Iss 2, p 62 (2021)
We describe the implementation of a bespoke two arm hydraulically actuated robotic platform which is used to semi-autonomously cut approximately 50 mm diameter pipes of three different materials: cardboard, ABS plastic and aluminium. The system is de
Externí odkaz:
https://doaj.org/article/04767e1f166d40f089ab6e51d9a32d07
Autor:
Mark G Jones, Orestis G Andriotis, James JW Roberts, Kerry Lunn, Victoria J Tear, Lucy Cao, Kjetil Ask, David E Smart, Alessandra Bonfanti, Peter Johnson, Aiman Alzetani, Franco Conforti, Regan Doherty, Chester Y Lai, Benjamin Johnson, Konstantinos N Bourdakos, Sophie V Fletcher, Ben G Marshall, Sanjay Jogai, Christopher J Brereton, Serena J Chee, Christian H Ottensmeier, Patricia Sime, Jack Gauldie, Martin Kolb, Sumeet Mahajan, Aurelie Fabre, Atul Bhaskar, Wolfgang Jarolimek, Luca Richeldi, Katherine MA O'Reilly, Phillip D Monk, Philipp J Thurner, Donna E Davies
Publikováno v:
eLife, Vol 7 (2018)
Matrix stiffening with downstream activation of mechanosensitive pathways is strongly implicated in progressive fibrosis; however, pathologic changes in extracellular matrix (ECM) that initiate mechano-homeostasis dysregulation are not defined in hum
Externí odkaz:
https://doaj.org/article/2541e80c33c2458ba21e589aed967251