Výsledky vyhledávání - "P D, Lotlikar"

The expression of insulin-like growth factor II, hepatitis B virus X antigen and p21 in experimental hepatocarcinogenesis in tree shrews

Autor: J J, Su, G Z, Qin, R Q, Yan, D R, Huang, C, Yang, P D, Lotlikar

Publikováno v: Annals of the Academy of Medicine, Singapore. 28(1)

The purpose of this paper was to study the mechanism of synergistic effect in hepatocarcinogenesis induced by hepatitis B virus (HBV) infection and aflatoxin B1 (AFB1) intake. Immunohistochemical staining was used in formalin-fixed, paraffin-embedded

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26b2b1dceb6c1dde68d4327504bab9e4
https://pubmed.ncbi.nlm.nih.gov/10374027

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Cytochrome P-450 catalysed activation of carcinogenic aromatic amines and amides

Autor: P. D. Lotlikar

Publikováno v: N-Oxidation of Drugs ISBN: 9789401053785

Aromatic amines and amides need to be metabolized in any animal species before they are carcinogenic in that species, because large amounts of compounds are required for tumour induction and tumours appear at sites distant from those of administratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fb568ebaec15e7f0c13804b02410c53
https://doi.org/10.1007/978-94-011-3112-4_18

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Aflatoxin B1-DNA binding and aflatoxin B1-glutathione conjugation with isolated hepatocytes from rats and hamsters

Autor: L L, Ho, E C, Jhee, P, Gopalan, K, Tsuji, P D, Lotlikar

Publikováno v: IARC scientific publications. (105)

Binding of aflatoxin B1 (AFB1) to DNA and AFB1-glutathione conjugation during the metabolism of AFB1 have been examined with freshly isolated hepatocytes from male Fischer rats and Syrian hamsters. Even though there was no significant difference in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8e193221b80ef123e38bf94723a744d
https://pubmed.ncbi.nlm.nih.gov/1906837

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Effect of 3-Methylcholanthrene Pretreatment on Aflatoxin B1Metabolism in Hamster Liver

Autor: L. L. Ho, K. Santhanam, P. D. Lotlikar

Publikováno v: Journal of Toxicology: Toxin Reviews. 8:165-173

The effects of 3-methylcholanthrene (MC) pretreatment of hamsters on the hepatic metabolism of aflatoxin B1 (AFB1) have been investigated in studies with subcellular, isolated hepatocytes and in vivo. Pretreatment of hamsters with MC (2.5 mg/100 g bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::909ee531e9d41faab800894dcfbe7bf7
https://doi.org/10.3109/15569548909059748

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Metabolic activation of aromatic amines and dialkylnitrosamines

Autor: P. D. Lotlikar

Publikováno v: Journal of Cancer Research and Clinical Oncology. 99:125-136

Metabolic activation steps involved in carcinogenesis by several aromatic amines, their N-acetylated derivatives, and dialkylnitrosamines are reviewed. N-Hydroxylation is the first activation step in the carcinogenesis by 2-acetylaminofluorene (AAF),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527a91bf87a22efd34d7912649bc19b9
https://doi.org/10.1007/bf00412448

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Metabolic Basis for Susceptibility and Resistance to Aflatoxin B1Hepatocarcinogenesis in Rodents

Autor: P. D. Lotlikar

Publikováno v: Journal of Toxicology: Toxin Reviews. 8:97-109

Hepatocarcinogen, aflatoxin B1 (AFB1), undergoes metabolic activation via epoxidation and the interaction of this epoxide with DNA is believed to be responsible for its initiation of carcinogenesis. Several in vitro and in vivo studies suggest that e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49a0789e57eec5484561236c7319c513
https://doi.org/10.3109/15569548909059742

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Inhibition of Dimethylnitrosamine-Induced Strand Breaks in Liver DNA and Liver Cell Necrosis by Diethyldithiocarbamate 2

Autor: S. K. Chang, J. A. Popp, s. E. Abanobi, D. Hadjiolov, M. Levitt, G. W. Harrington, P. D. Lotlikar, D. S. R. Sarma, S. Rajalakshmi

Publikováno v: JNCI: Journal of the National Cancer Institute. 58:263-271

Diethyldithiocarbamate (DEDTC) prevented dimethylnitrosamine (DMN)-induced strand breaks in liver DNA and liver cell necrosis in male Wistar rats. In contrast, DEDTC did not inhibit the fragmentation of liver DNA caused by several other chemical carc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::395da4a05fb960090055a4332c7ef952
https://doi.org/10.1093/jnci/58.2.263

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Effects of adrenalectomy and bile-duct ligation on the urinary excretion of metabolites of 2-acetamidofluorene by male weanling rats

Autor: P D Lotlikar, M Gruenstein

Publikováno v: Biochemical Journal. 119:921-923

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efafd77dec0e56230cd6d8acd7345592
https://doi.org/10.1042/bj1190921

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Enzymic N-acetylation of N-hydroxy-2-aminofluorene by liver cytosol from various species

Autor: P D Lotlikar, L Luha

Publikováno v: Biochemical Journal. 123:287-289

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6273e0e62efd11667a1e9aa586d57d
https://doi.org/10.1042/bj1230287

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Lack of effect of glutathione on the binding of dimethylnitrosamine to DNA in vitro

Autor: H R, Prasanna, H G, Raj, P D, Lotlikar, P N, Magee

Publikováno v: Molecular toxicology. 1(2-3)

The possibility that glutathione (GSH) S-transferases may affect microsome-mediated methylation of DNA by dimethylnitrosamine (DMN) in vitro has been investigated using aflatoxin B1 (AFB1) as a positive control. Hamster liver microsomes were incubate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8174c8c404dcdf56511a9bbb07be4870
https://pubmed.ncbi.nlm.nih.gov/3130567

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