Zobrazeno 1 - 10
of 46
pro vyhledávání: '"P D, Josephy"'
Publikováno v:
Environmental and Molecular Mutagenesis. 35:328-335
Understanding the relationships between the sequences and catalytic activities of P450 enzymes that catalyze the bioactivation of mutagens and carcinogens is an important goal in mutation research. Escherichia coli strain DJ4309 expresses recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d255c4938fb8d0be586924d2b89138a
https://doi.org/10.1002/1098-2280(2000)35:4<328::aid-em7>3.0.co
https://doi.org/10.1002/1098-2280(2000)35:4<328::aid-em7>3.0.co
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 74:565-571
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::578c840e1aea0fcdba3c7619ac2338d7
https://doi.org/10.1139/y96-054
https://doi.org/10.1139/y96-054
Publikováno v:
Carcinogenesis. 16:2037-2043
Escherichia coli lacZ strains CC107-CC111, which detect specific frameshift mutations, were used to study the mutational specificities of 2-nitro-3-methylimidazo[4,5-f] quinoline (NO2-IQ) and rat hepatic S9-activated 2-amino-3-methylimidazo[4,5-f]qui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a3db5901b766ac59ee3a1b8150412b
https://doi.org/10.1093/carcin/16.9.2037
https://doi.org/10.1093/carcin/16.9.2037
Publikováno v:
Infection and Immunity. 62:2662-2668
The respiratory burst of neutrophils is believed to kill bacteria by generating oxidative species, such as superoxide anion, hydrogen peroxide, and oxidized halogen species. The oxyR gene of Salmonella typhimurium controls a regulon induced by oxidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc6bad549b3d40b659724c268e080c6
https://doi.org/10.1128/iai.62.7.2662-2668.1994
https://doi.org/10.1128/iai.62.7.2662-2668.1994
Publikováno v:
Chemical research in toxicology. 14(11)
An increased risk of breast cancer has been observed in women who consume "very well-done" meats. Heterocyclic amines are mutagenic and carcinogenic pyrolysis products formed during high temperature cooking of meats. In the present study, human milk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4555f10a1120a2225b7b7696446e5a
https://pubmed.ncbi.nlm.nih.gov/11712910
https://pubmed.ncbi.nlm.nih.gov/11712910
Publikováno v:
Environmental and molecular mutagenesis. 35(4)
Understanding the relationships between the sequences and catalytic activities of P450 enzymes that catalyze the bioactivation of mutagens and carcinogens is an important goal in mutation research. Escherichia coli strain DJ4309 expresses recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4077e84984e55f813018c9f9f3be6dea
https://pubmed.ncbi.nlm.nih.gov/10861951
https://pubmed.ncbi.nlm.nih.gov/10861951
Publikováno v:
Biochemistry. 38(17)
Random mutagenesis is an approach that has the potential to provide useful information about cytochrome P450 (P450) enzymes but has not been extensively used to date. We applied our previously developed systems for generation of random libraries of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38256b21d5964bdf270fdaf84b88cf63
https://pubmed.ncbi.nlm.nih.gov/10220313
https://pubmed.ncbi.nlm.nih.gov/10220313
Autor:
P D, Josephy, B L, Coomber
Publikováno v:
Canadian journal of physiology and pharmacology. 76(7-8)
Many chemical carcinogens target epithelial tissues, but the biological and biochemical bases of carcinogen specificity remain largely unknown. Focusing on the mammary gland, we discuss the concept that neutrophils metabolize carcinogens to reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0a4abb7facccbc75fcbbe02f9b8cca4
https://pubmed.ncbi.nlm.nih.gov/10030448
https://pubmed.ncbi.nlm.nih.gov/10030448
Publikováno v:
Chemical research in toxicology. 12(1)
Environmental chemicals may play a role in the etiology of human breast cancer. Aromatic amines, industrial chemicals found as environmental pollutants, have been identified as rat mammary carcinogens. We have detected the monocyclic aromatic amines,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08623e25121db2b68b458d38cbd33098
https://pubmed.ncbi.nlm.nih.gov/9894021
https://pubmed.ncbi.nlm.nih.gov/9894021
Publikováno v:
Chemical research in toxicology. 11(1)
We describe the construction of a new strain of Escherichia coli designed to bioactivate aromatic amines and to detect their mutagenicity with high sensitivity. Strain DJ4309 bears two plasmids, a pACYC184-derived plasmid which expresses Salmonella t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c696c14db91a0a96463e630761fa80db
https://pubmed.ncbi.nlm.nih.gov/9477228
https://pubmed.ncbi.nlm.nih.gov/9477228