Zobrazeno 1 - 10
of 16
pro vyhledávání: '"P D, Brophy"'
Autor:
A. M. Groves, C. J. Johnston, G. Beutner, J. E. Dahlstrom, M. Koina, M. O'Reilly, B. Marples, G. Porter, P. D. Brophy, A. L. Kent
Publikováno v:
Physiological Reports, Vol 11, Iss 15, Pp n/a-n/a (2023)
Abstract Hypoxic ischemic encephalopathy (HIE) occurs in 2–5/1000 births, with acute kidney injury (AKI) occurring in 40%. AKI increases morbidity and mortality. Caffeine, an adenosine receptor antagonist, and photobiomodulation (PBM), working on c
Externí odkaz:
https://doaj.org/article/b80fd1d0af824b9cb58b63ab0b4e672a
Autor:
Angela M. Groves, Carl J. Johnston, Gisela G. Beutner, Jane E. Dahlstrom, Mark Koina, Michael A. O'Reilly, George Porter, Patrick D. Brophy, Alison L. Kent
Publikováno v:
Physiological Reports, Vol 10, Iss 24, Pp n/a-n/a (2022)
Abstract Hypoxic ischemic encephalopathy (HIE) is associated with acute kidney injury (AKI) in neonates with birth asphyxia. This study aimed to utilize urinary biomarkers to characterize AKI in an established neonatal rat model of HIE. Day 7 Sprague
Externí odkaz:
https://doaj.org/article/666f53fc97c046118c02b61e3050900d
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Remuneration issues are a substantial threat to the long-term stability of the pediatric nephrology workforce. It is uncertain whether the pediatric nephrology workforce will meet the growing needs of children with kidney disease without a substantia
Externí odkaz:
https://doaj.org/article/47dec7993869490a93729cabb4dfc75f
Predicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome Using Plasma Metabolomics
Autor:
Jessica R. Gooding, Shipra Agrawal, Susan McRitchie, Zach Acuff, Michael L. Merchant, Jon B. Klein, William E. Smoyer, Susan J. Sumner, John Mahan, Hiren Patel, Richard F. Ransom, Cynthia Pan, Denis F. Geary, Myra L. Chang, Keisha L. Gibson, Franca M. Iorember, Patrick D. Brophy, Tarak Srivastava, Larry A. Greenbaum
Publikováno v:
Kidney International Reports, Vol 5, Iss 1, Pp 81-93 (2020)
Introduction: Nephrotic syndrome (NS) is a kidney disease that affects both children and adults. Glucocorticoids have been the primary therapy for >60 years but are ineffective in approximately 20% of children and approximately 50% of adult patients.
Externí odkaz:
https://doaj.org/article/1b5280e5d877451bafee09b406b2ee8f
Autor:
Shipra Agrawal, Michael L. Merchant, Jiro Kino, Ming Li, Daniel W. Wilkey, Adam E. Gaweda, Michael E. Brier, Melinda A. Chanley, Jessica R. Gooding, Susan J. Sumner, Jon B. Klein, William E. Smoyer, John Mahan, Hiren Patel, Richard F. Ransom, Cynthia Pan, Denis F. Geary, Myra L. Chang, Keisha L. Gibson, Franca M. Iorember, Patrick D. Brophy, Tarak Srivastava, Larry A. Greenbaum
Publikováno v:
Kidney International Reports, Vol 5, Iss 1, Pp 66-80 (2020)
Introduction: Nephrotic syndrome (NS) is a characterized by massive proteinuria, edema, hypoalbuminemia, and dyslipidemia. Glucocorticoids (GCs), the primary therapy for >60 years, are ineffective in approximately 50% of adults and approximately 20%
Externí odkaz:
https://doaj.org/article/4a6071bc69c54f03bf4f8c130ca5d000
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Minimal change disease (MCD) is the most common cause of nephrotic syndrome worldwide. For decades, the foundation of the treatment has been corticosteroids. However, relapse rate is high and up to 40% of patients develop frequent relapsing/steroid d
Externí odkaz:
https://doaj.org/article/77a79cd47ab54c3b924beffc7de43d8e
Publikováno v:
Radiology Case Reports, Vol 13, Iss 1, Pp 130-134 (2018)
One of the main causes of failure in uterine fibroid embolization procedures is incomplete infarction of the fibroid due to alternate vascular supply to the fibroid which was not identified by the operator. Cone-beam computed tomography angiography w
Externí odkaz:
https://doaj.org/article/7bba41ab678040388fdc1f37ecf3e1bd
Autor:
Dong Liang, Kirk M McHugh, Pat D Brophy, Nader Shaikh, J Robert Manak, Peter Andrews, Inessa Hakker, Zihua Wang, Andrew L Schwaderer, David S Hains
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220617 (2019)
Vesicoureteral reflux (VUR) is a complex, heritable disorder. Genome-wide linkage analyses of families affected by VUR have revealed multiple genomic loci linked to VUR. These loci normally harbor a number of genes whose biologically functional varia
Externí odkaz:
https://doaj.org/article/abe8a36d8bb7487d9ac0f2115dde8d7d
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Rheumatoid arthritis (RA) is a chronic, inflammatory disease that affects 1% of the general population. Fatigue is a common complaint of patients with RA, however their perceived fatigue may be more exacerbated than objective measures of fatigue may
Externí odkaz:
https://doaj.org/article/661e705d202942fca44ce7c54364209d
Autor:
Jason L Picconi, Melissa A Muff-Luett, Di Wu, Erik Bunchman, Franz Schaefer, Patrick D Brophy
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Gene therapy targeting of kidneys has been largely unsuccessful. Recently, a recombinant adeno-associated virus (rAAV) vector was used to target adult mouse kidneys. Our hypothesis is that a pseudotyped rAAV 2/9 vector can produce fetal kidney-specif
Externí odkaz:
https://doaj.org/article/376c7dbd22e34dcd89bff69c27dc4293