Characterization of Collaborative Cross mouse founder strain CAST/EiJ as a novel model for lethal COVID-19

Autor: Candice N. Baker, Debra Duso, Nagarama Kothapalli, Tricia Hart, Sean Casey, Tres Cookenham, Larry Kummer, Janine Hvizdos, Kathleen Lanzer, Purva Vats, Priya Shanbhag, Isaac Bell, Mike Tighe, Kelsey Travis, Frank Szaba, Jeffrey M. Harder, Olivia Bedard, Natalie Oberding, Jerrold M. Ward, Mark D. Adams, Cathleen Lutz, Shelton S. Bradrick, William W. Reiley, Nadia A. Rosenthal

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract Mutations in SARS-CoV-2 variants of concern (VOCs) have expanded the viral host range beyond primates, and a few other mammals, to mice, affording the opportunity to exploit genetically diverse mouse panels to model the broad spectrum of res

Externí odkaz: https://doaj.org/article/2c9c9826453141688a649f8f972e01a2

Stop The Falls! A framework for injury prevention outreach for older adults presented by the American Association for the Surgery of Trauma Geriatric Trauma and Injury Prevention Committees

Autor: Bellal Joseph, Vanessa P Ho, Molly P Jarman, Nasim Ahmed, D'Andrea Joseph, Tasce Bongiovanni, Kartik Prabhakaran, Thomas K Duncan, Asanthi Ratnasekera, Kristin P Colling, Sasha D Adams, Sigrid Burruss, Melissa Hornor, Jennifer Knight-Davis, Tanya Egodage, Elizabeth Gorman, Adin Tyler Putnam, Caitlin Cohan

Publikováno v: Trauma Surgery & Acute Care Open, Vol 9, Iss 1 (2024)

With the increasing age of the population in the USA, fall prevention events to target older patients are imperative. The American Association for the Surgery of Trauma hosted a fall prevention event at the host city of the 2023 Annual Meeting. We re

Externí odkaz: https://doaj.org/article/1abafb8ea9834f949d61967093d14f83

METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence

Autor: Chen Wang, Hideki Tanizawa, Connor Hill, Aaron Havas, Qiang Zhang, Liping Liao, Xue Hao, Xue Lei, Lu Wang, Hao Nie, Yuan Qi, Bin Tian, Alessandro Gardini, Andrew V. Kossenkov, Aaron Goldman, Shelley L. Berger, Ken-ichi Noma, Peter D. Adams, Rugang Zhang

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract METTL3 is the catalytic subunit of the methyltransferase complex, which mediates m6A modification to regulate gene expression. In addition, METTL3 regulates transcription in an enzymatic activity-independent manner by driving changes in high

Externí odkaz: https://doaj.org/article/510df8c88f934aa994ca58141deaa581

An inclusive Research and Education Community (iREC) model to facilitate undergraduate science education reform

Autor: Denise L. Monti, Julia C. Gill, Tamarah L. Adair, Sandra D. Adams, Yesmi Patricia Ahumada-Santos, Isabel Amaya, Kirk Anders, Justin R. Anderson, Mauricio S. Antunes, Mary Ayuk, Frederick Baliraine, Tonya C. Bates, Andrea R. Beyer, Suparna Bhalla, Tejas Bouklas, Sharon K. Bullock, Kristen A. Butela, Christine Byrum, Steven M. Caruso, Rebecca Chong, Hui-Min Chung, Stephanie B. Conant, Brett Condon, Katie E. Crump, Tom D'Elia, Megan K. Dennis, Linda C. DeVeaux, Lautaro Diacovich, Arturo Diaz, Iain Duffy, Dustin Edwards, Patricia C. Fallest-Strobl, Ann Findley, Matthew R. Fisher, Marie P. Fogarty, Victoria Jane Frost, Maria D. Gainey, Courtney S. Galle, Bryan Gibb, Urszula Golebiewska, Hugo Gramajo, Anna S. Grinath, Jennifer Guerrero, Nancy Guild, Kathryn E. Gunn, Susan Gurney, Lee E. Hughes, Pradeepa Jayachandran, Kristen Johnson, Allison Johnson, Alison E. Kanak, Michelle L. Kanther, Rodney A. King, Kathryn Kohl, Julia Lee-Soety, Lynn O. Lewis, Heather Lindberg, Jaclyn A. Madden, Breonna J. Martin, Matthew D. Mastropaolo, Sean McClory, Evan C. Merkhofer, Julie A. Merkle, Jon Mitchell, María Alejandra Mussi, Fernando Nieto, Jillian Nissen, Imade Yolanda Nsa, Mary G. O'Donnell, R. Deborah Overath, Shallee T. Page, Andrea Panagakis, Jesús Ricardo Parra Unda, Michelle B. Pass, Tiara Perez Morales, Nick T. Peters, Ruth Plymale, Richard Pollenz, Nathan S. Reyna, Claire A. Rinehart, Jessica Rocheleau, John S. Rombold, Ombeline Rossier, Adam D. Rudner, Elizabeth E. Rueschhoff, Christopher D. Shaffer, Mary Ann V. Smith, Amy B. Sprenkle, C. Nicole Sunnen, Michael A. Thomas, Michelle M. Tigges, Deborah Tobiason, Sara Sybesma Tolsma, Julie Torruellas Garcia, Peter Uetz, Edwin Vazquez, Catherine M. Ward, Vassie C. Ware, Jacqueline M. Washington, Matthew J. Waterman, Daniel E. Westholm, Keith A. Wheaton, Simon J. White, Elizabeth C. Williams, Daniel C. Williams, Ellen M. Wisner, William H. Biederman, Steven G. Cresawn, Danielle M. Heller, Deborah Jacobs-Sera, Daniel A. Russell, Graham F. Hatfull, David J. Asai, David I. Hanauer, Mark J. Graham, Viknesh Sivanathan

Publikováno v: Frontiers in Education, Vol 9 (2024)

Over the last two decades, there have been numerous initiatives to improve undergraduate student outcomes in STEM. One model for scalable reform is the inclusive Research Education Community (iREC). In an iREC, STEM faculty from colleges and universi

Externí odkaz: https://doaj.org/article/f50dca97413047c5972e7d31f6d2f587

The role of flourishing in the STEM trajectories of emerging adults

Autor: Karen Hammerness, Rachel Chaffee, Peter Bjorklund, Priya-Syrina Li Hinton, Alan J. Daly, Anna MacPherson, Preeti Gupta, Jennifer D. Adams, Coral Braverman, Jahneal Francis, Lucie Lagodich, Lois Wu, Mahmoud Abouelkheir

Publikováno v: Frontiers in Education, Vol 9 (2024)

We focus on the use of flourishing as a new measure in studies of pathways in STEM (science, technology, engineering, and mathematical) fields. While the concept of flourishing is promising, the concept may need careful interrogation to ensure it tak

Externí odkaz: https://doaj.org/article/8d403a9820d24727bbeb3885936b8940