Zobrazeno 1 - 10
of 26
pro vyhledávání: '"P Christine Ackroyd"'
Autor:
Charles M Voyton, Yijian Qiu, Meredith T Morris, P Christine Ackroyd, Jimmy Suryadi, Logan Crowe, James C Morris, Kenneth A Christensen
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006523 (2018)
The bloodstream lifecycle stage of the kinetoplastid parasite Trypanosoma brucei relies solely on glucose metabolism for ATP production, which occurs in peroxisome-like organelles (glycosomes). Many studies have been conducted on glucose uptake and m
Externí odkaz:
https://doaj.org/article/b014a00f839248f6ac2050447e9ea8a4
Autor:
Michael S Rogers, Lorna M Cryan, Kaiane A Habeshian, Lauren Bazinet, Thomas P Caldwell, P Christine Ackroyd, Kenneth A Christensen
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39911 (2012)
Anti-angiogenic therapies are effective for the treatment of cancer, a variety of ocular diseases, and have potential benefits in cardiovascular disease, arthritis, and psoriasis. We have previously shown that anthrax protective antigen (PA), a non-p
Externí odkaz:
https://doaj.org/article/55c5e1601b864d598297d7ee12903fa7
Autor:
Robert K. Roden, Fangfang Jiang, Alyssa Nitz, Nathan Zuniga, Rebecca S. Burlett, Leena M. Patil, Holly Farnsworth, P. Christine Ackroyd, Samuel H. Payne, John C. Price, Kenneth A. Christensen
Dry eye disease (DED) affects up to half of the world's population and causes blur, eye pain, decreased quality of life. Unfortunately, many people do not receive proper treatment due to current challenges associated with DED diagnoses. To address th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26405108ccbfd30c58b54826c245d925
https://doi.org/10.1101/2023.05.18.23290182
https://doi.org/10.1101/2023.05.18.23290182
Autor:
Robert K. Roden, Fangfang Jiang, Nathan Zuniga, Alyssa Nitz, Rebecca S. Burlett, Joshua C. Wright, Caleb Shelton, Alex Reed, Samantha Latham, Connor O. Roper, Leena M. Patil, P. Christine Ackroyd, Samuel H. Payne, John C. Price, Kenneth A. Christensen
Soft contact lenses (SCLs) have recently been introduced as an alternative method for human tear protein sampling. However, SCLs are available in a variety of chemical compositions which affect protein binding specificity. Here we analyzed 8 differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76eeb2f7e79cd1e66a855b7b3b2ef22f
https://doi.org/10.1101/2023.05.17.23290135
https://doi.org/10.1101/2023.05.17.23290135
Autor:
Lorna M. Cryan, Tsz-Ming Tsang, Jessica Stiles, Lauren Bazinet, Sai Lun Lee, Samuel Garrard, Erika Madrian, Cody Roberts, Jessie Payne, Andrew Jensen, Arthur E. Frankel, P. Christine Ackroyd, Kenneth A. Christensen, Michael S. Rogers
Publikováno v:
Angiogenesis. 25:397-410
Anthrax protective antigen (PA) is a potent inhibitor of pathological angiogenesis with an unknown mechanism. In anthrax intoxication, PA interacts with capillary morphogenesis gene 2 (CMG2) and tumor endothelial marker 8 (TEM8). Here, we show that C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101c1169053690fbf1b65582523a87ce
https://doi.org/10.1007/s10456-022-09833-w
https://doi.org/10.1007/s10456-022-09833-w
Autor:
Robert K. Roden, Nathan Zuniga, Joshua C. Wright, David H. Parkinson, Leena M. Patil, Fangfang Jiang, Rebecca S. Burlett, Joshua J. Rogers, Jarett T. Pittman, Connor O. Roper, Kenneth L. Virgin, P. Christine Ackroyd, John C. Price, Kenneth A. Christensen
Human tear protein biomarkers are useful for detecting both ocular and systemic diseases. Unfortunately, existing tear film sampling methods (Schirmer strips [SS] and microcapillary tubes [MCT]) have significant drawbacks. Here we present an alternat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8943528a318129605da241dc4a2e7626
https://doi.org/10.1101/2023.02.09.23285551
https://doi.org/10.1101/2023.02.09.23285551
Publikováno v:
ACS Infectious Diseases. 4:1058-1066
Trypanosoma brucei, which causes human African typanosomiasis (HAT), derives cellular ATP from glucose metabolism while in the mammalian host. Targeting glucose uptake or regulation in the parasite has been proposed as a potential therapeutic strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996172e06df98e0b8c0861ac75c027d1
https://doi.org/10.1021/acsinfecdis.8b00058
https://doi.org/10.1021/acsinfecdis.8b00058
Autor:
Sheng Lin, Charles Voyton, Meredith Morris, P. Christine Ackroyd, James Morris, Kenneth A. Christensen
Publikováno v:
Journal of Biological Chemistry. 292:7795-7805
Here we report the use of a fluorescein-tagged peroxisomal targeting sequence peptide (F-PTS1, acetyl-C{K(FITC)}GGAKL) for investigating pH regulation of glycosomes in live procyclic form Trypanosoma brucei. When added to cells, this fluorescent pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e2097e4e1111a38a6d12185c3da7305
https://doi.org/10.1074/jbc.m117.784173
https://doi.org/10.1074/jbc.m117.784173
Autor:
Lauren Bazinet, Sai Lun Lee, P. Christine Ackroyd, Michael S. Rogers, Samuel Garrard, Jessie Payne, Kenneth A. Christensen, Tsz-Ming Tsang, Cody Roberts, Lorna M. Cryan, Jessica Stiles
Pathological angiogenesis contributes to diseases as varied as cancer and corneal neovascularization. The vascular endothelial growth factor (VEGF) - VEGF receptor 2 (KDR/VEGFR2) axis has been the major target for treating pathological angiogenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50106cb83127e1464d19e67edbbd88c
Autor:
Jordan G. Finnell, Kenneth A. Christensen, Sai Lun Lee, Michael S. Rogers, P. Christine Ackroyd, Lorna M. Cryan, Tsz-Ming Tsang, Samuel Garrard
Capillary Morphogenesis Gene 2 protein (CMG2) is a transmembrane, integrin-like receptor and the primary receptor for the anthrax toxin. In addition to its role as an anthrax toxin receptor, CMG2 has been repeatedly shown to play a role in angiogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d772356d9b69fa15a164eab77d7331b
https://doi.org/10.1101/705459
https://doi.org/10.1101/705459