Zobrazeno 1 - 10
of 294
pro vyhledávání: '"P Cernacek"'
Autor:
P Cernacek, Sheldon Magder
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 81:635-643
Shock is a condition where blood flow is inadequate for tissue needs. In all forms of shock, the concentrations of endothelins (ETs) are elevated, and they are especially high in septic shock. The rise in ETs plasma levels may initially have some pos
Publikováno v:
Transplantation. 61:791-797
Endothelins (ET) are potent vasoconstrictors that are directly mitogenic for vascular smooth muscle cells and fibroblasts. It is possible that the vasoconstrictor and mitogenic effects of ET could play a significant role in the vascular remodeling pr
Publikováno v:
American Journal of Physiology-Renal Physiology. 268:F416-F422
The influence of pregnancy on renal responses to atrial natriuretic factor (ANF) was determined in urethane-anesthetized Sprague-Dawley rats. Infusions of ANF caused a significantly greater increase in urinary excretion of fluid, sodium, and potassiu
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 71:227-233
Endothelin-1 (ET-1) is a 21 amino acid vasoconstrictor peptide produced by endothelial cells, the expression of which is modulated by a variety of vasoconstrictors, vasodilators, and inflammatory mediators. Hypoxia has been shown to increase ET-1 exp
Publikováno v:
Circulation. 85:510-517
BACKGROUND The possible contribution of endothelin-1, a potent endothelium-derived vasoconstrictor peptide, to neurohumoral compensation for hemodynamic stress was examined in nine normal volunteers and six patients with severe congestive heart failu
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 11:197-199
The purpose of this study was to determine if endothelin-1 (ET-1) mediates endothelium-dependent enhancement of rat aortic contractility following exposure to hypoxia. Rats breathed room air or 10% oxygen for 12 or 48 h. Thoracic aortas and plasma we
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(3)
Pulmonary hypertension is associated with endothelial dysfunction that may mediate or contribute to the disease process; among those abnormalities is an increase in circulating endothelin-1 levels. We investigated the effect of the orally active endo
Autor:
M, Levy, P, Cernacek
Publikováno v:
Clinical and investigative medicine. Medecine clinique et experimentale. 19(6)
To test the effect of atrial natriuretic peptide (ANF) in dogs with acute pulmonary edema in the absence of urinary sodium retention. ANF is normally a potent natriuretic agent, although this effect is attenuated in generalized edema or acute renal f
Publikováno v:
The American journal of physiology. 271(1 Pt 2)
The present studies were done to determine if the attenuation of the natriuretic and diuretic effects of atrial natriuretic factor (ANF) during rat pregnancy was caused by an increase in its metabolism. It was found that the plasma half-life (min), p
Publikováno v:
Transplantation. 61(5)
Endothelins (ET) are potent vasoconstrictors that are directly mitogenic for vascular smooth muscle cells and fibroblasts. It is possible that the vasoconstrictor and mitogenic effects of ET could play a significant role in the vascular remodeling pr