Zobrazeno 1 - 10
of 40
pro vyhledávání: '"P C Gaskell"'
Autor:
Ping-I Lin, Kathleen A. Welsh-Bohmer, Christine M. Hulette, William K. Scott, Michael A. Slifer, C.F. Potocky, Donald E. Schmechel, Jeffery M. Vance, Margaret A. Pericak-Vance, P. C. Gaskell, Regina M. Carney
Publikováno v:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :571-578
Historically, data for genetic studies are collected at one time point. However, for diseases with late onset or with complex phenotypes, such as Alzheimer disease (AD), restricting diagnosis to a single ascertainment contact may not be sufficient. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272a63bdf2f673614476ea042d1f1526
https://doi.org/10.1002/ajmg.b.30590
https://doi.org/10.1002/ajmg.b.30590
Autor:
H Gwirtsman, Lynne L. McFarland, J Bartlett, B Lynch, Lan Jiang, Paola G. Bronson, P C Gaskell, M. Bembe, Margaret A. Pericak-Vance, Eden R. Martin, Nathalie Schnetz-Boutaud, John R. Gilbert, Shannon J. Kenealy, X Liang, Jonathan L. Haines
Publikováno v:
Molecular Psychiatry. 11:280-285
Alzheimer disease (AD) is a progressive neurodegenerative disorder of later life with a complex etiology and a strong genetic component. Several genomic screens have suggested that a region between chromosome 12p13 and 12q22 contains at least one add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab500e9ff7bca13c758253ea754ea534
https://doi.org/10.1038/sj.mp.4001766
https://doi.org/10.1038/sj.mp.4001766
Autor:
Carlyn K. Rosenberg, John R. Gilbert, Christine M. Hulette, Ann M. Saunders, Margaret A. Pericak-Vance, P. C. Gaskell
Publikováno v:
Acta Neuropathologica. 100:145-152
Mutations in the amyloid precursor protein (APP) gene cause one form of early onset familial Alzheimer's disease (AD). One such family has been studied genetically and neuropathologically and represents the basis of the present report. Four siblings
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00ecb5fef38c6582f15a129289c01de
https://doi.org/10.1007/s004019900155
https://doi.org/10.1007/s004019900155
Autor:
B.L. Rosi, William K. Scott, Margaret A. Pericak-Vance, P. C. Gaskell, Gary W. Small, Lindsay A. Farrer, Larry H. Yamaoka, P. A. Locke, Jonathan L. Haines, Ann M. Saunders, John H. Growdon, A. D. Roses, P. M. Conneally
Publikováno v:
Genetic Epidemiology. 14:307-315
Recent reports have shown an association between an intronic polymorphism of the presenilin-1 (PSEN1) gene and late-onset (age at onset > 65) familial and sporadic (no family history) Alzheimer disease (AD). The reported association was independent o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8900d2f13968ce700a913e144deab38d
https://doi.org/10.1002/(sici)1098-2272(1997)14:3<307::aid-gepi8>3.0.co
https://doi.org/10.1002/(sici)1098-2272(1997)14:3<307::aid-gepi8>3.0.co
Autor:
Donald E. Schmechel, P. C. Gaskell, John C.S. Breitner, Margaret A. Pericak-Vance, Carolyn Rosenberg, Kathleen A. Welsh-Bohmer, Barbara J. Crain, Christine M. Hulette, James R. Burke, Ann M. Saunders, Mark J. Alberts, Warren J. Strittmatter, A. D. Roses, S. V. Scott
Publikováno v:
The Lancet. 348:90-93
Summary Background We aimed to determine the specificity, sensitivity, and predictive value of apolipoprotein E (APOE) genotyping in 67 consecutive patients with clinical diagnoses of sporadic Alzheimer's disease (AD) who underwent necropsy. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7369bf4c3505073c7da0537c88113e
https://doi.org/10.1016/s0140-6736(96)01251-2
https://doi.org/10.1016/s0140-6736(96)01251-2
Autor:
Lindsay A. Farrer, P. M. Conneally, Joellen M. Schildkraut, Gary W. Small, P. A. Locke, M.L. Pritchard, Larry H. Yamaoka, Jonathan L. Haines, S. A. Auerbach, Ann M. Saunders, James F. Gusella, P. C. Gaskell, B.L. Rosi, Margaret A. Pericak-Vance, A. D. Roses, John H. Growdon
Publikováno v:
Genomics. 33:53-56
Alzheimer disease (AD) is the most common neurodegenerative disorder for individuals over the age of 40. AD has a complex etiology, and it is likely that multiple genes, acting independently and/or interacting, affect the risk of developing AD. Sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e39b45afbe34230125968e837eda1e
https://doi.org/10.1006/geno.1996.0158
https://doi.org/10.1006/geno.1996.0158
Autor:
A. D. Roses, Larry H. Yamaoka, P. C. Gaskell, John H. Growdon, Jonathan L. Haines, Rudolph E. Tanzi, Margaret A. Pericak-Vance, James F. Gusella, Barbara J. Crain, Christine M. Hulette, P. St. George-Hyslop
Publikováno v:
Genetic Epidemiology. 10:361-364
Familial Alzheimer disease is a neurological disorder of adult onset. Three research centers have each contributed their families and genetic linkage data for combined analyses. The data from the Duke and Boston centers, comprising 73 pedigrees for w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1773e5ef277372872fd3b4cd2ed7c8e1
https://doi.org/10.1002/gepi.1370100605
https://doi.org/10.1002/gepi.1370100605
Autor:
Jonathan L. Haines, A. D. Roses, S. A. Auerbach, Margaret A. Pericak-Vance, John H. Growdon, William K. Scott, Ann M. Saunders, Lindsay A. Farrer, P. A. Locke, P. C. Gaskell
Publikováno v:
Annals of Neurology. 42:376-378
We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cecb92fa248c784a323dcaaae6f51d2
https://doi.org/10.1002/ana.410420317
https://doi.org/10.1002/ana.410420317
Autor:
Marilyn Creason, P. C. Gaskell, Charles E. Jackson, Susan H. Slifer, Amy E. Crunk, Charles C. Kroner, Eden R. Martin, Joelle M. van der Walt, Margaret A. Pericak-Vance, William K. Scott, Lynne L. McFarland, Jonathan L. Haines, Kathleen A. Welsh-Bohmer, Denise Fuzzell
Publikováno v:
Human genetics. 118(1)
Old Order Amish, founded by a small number of Swiss immigrants, exist in culturally isolated communities across rural North America. The consequences of genetic isolation and inbreeding within this group are evident by increased frequencies of many m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851ef21fb5987567e240920d790cea21
https://pubmed.ncbi.nlm.nih.gov/16078048
https://pubmed.ncbi.nlm.nih.gov/16078048
Autor:
Kathleen A. Welsh-Bohmer, Charles E. Jackson, William K. Scott, P. C. Gaskell, Yujun Shao, J. B. Rimmler, Allison E. Ashley-Koch, Margaret A. Pericak-Vance, Jonathan L. Haines
Publikováno v:
Neuroscience letters. 379(3)
Apolipoprotein E (APOE) is the only universally confirmed susceptibility gene for late-onset Alzheimer disease (LOAD), although many loci are believed to modulate LOAD risk. The genetic homogeneity of isolated populations, such as the Amish, potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9298f692a2d2673991c44bdb301688d2
https://pubmed.ncbi.nlm.nih.gov/15843063
https://pubmed.ncbi.nlm.nih.gov/15843063