Zobrazeno 1 - 10
of 10
pro vyhledávání: '"P C Donaghy"'
Autor:
Gemma Greenfinch, Calum A. Hamilton, Paul C. Donaghy, Michael Firbank, Nicola A. Barnett, Louise Allan, George S. Petrides, John-Paul Taylor, John T. O'Brien, Alan J. Thomas
Publikováno v:
BJPsych Open, Vol 10 (2024)
The aim of this study was to determine whether there was a significant change in cardiac [123I]-metaiodobenzylguanidine uptake between baseline and follow-up in individuals with mild cognitive impairment with Lewy bodies (MCI-LB) who had normal basel
Externí odkaz:
https://doaj.org/article/e519faefdb544755935a18184234e2cc
Autor:
Kathryn A. Wyman-Chick, Parichita Chaudhury, Ece Bayram, Carla Abdelnour, Elie Matar, Shannon Y. Chiu, Daniel Ferreira, Calum A. Hamilton, Paul C. Donaghy, Federico Rodriguez-Porcel, Jon B. Toledo, Annegret Habich, Matthew J. Barrett, Bhavana Patel, Alberto Jaramillo-Jimenez, Gregory D. Scott, Joseph P. M. Kane
Publikováno v:
Neurology and Therapy, Vol 13, Iss 3, Pp 885-906 (2024)
Abstract This pragmatic review synthesises the current understanding of prodromal dementia with Lewy bodies (pDLB) and prodromal Alzheimer’s disease (pAD), including clinical presentations, neuropsychological profiles, neuropsychiatric symptoms, bi
Externí odkaz:
https://doaj.org/article/eeb3302b9954467faf0ca0b4ceb4c0be
Autor:
Xiaobei Pan, Paul C. Donaghy, Gemma Roberts, Leonidas Chouliaras, John T. O’Brien, Alan J. Thomas, Amanda J. Heslegrave, Henrik Zetterberg, Bernadette McGuinness, Anthony P. Passmore, Brian D. Green, Joseph P. M. Kane
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2024)
BackgroundIn multifactorial diseases, alterations in the concentration of metabolites can identify novel pathological mechanisms at the intersection between genetic and environmental influences. This study aimed to profile the plasma metabolome of pa
Externí odkaz:
https://doaj.org/article/8aad56e5df91470bbb204ca5a316b750
Autor:
Jay Amin, Daniel Erskine, Paul C. Donaghy, Ajenthan Surendranathan, Peter Swann, Amy P. Kunicki, Delphine Boche, Clive Holmes, Ian G. McKeith, John T. O'Brien, Jessica L. Teeling, Alan J. Thomas
Publikováno v:
Neurobiology of Disease, Vol 168, Iss , Pp 105698- (2022)
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia, behind Alzheimer's disease (AD). The profile of inflammation in AD has been extensively researched in recent years, with evidence that chronic peripheral i
Externí odkaz:
https://doaj.org/article/1dfe16a3a9ee479096b69460084cc8ab
Autor:
Julia Schumacher, John-Paul Taylor, Calum A. Hamilton, Michael Firbank, Ruth A. Cromarty, Paul C. Donaghy, Gemma Roberts, Louise Allan, Jim Lloyd, Rory Durcan, Nicola Barnett, John T. O’Brien, Alan J. Thomas
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2020)
Abstract Objectives To investigate using quantitative EEG the (1) differences between patients with mild cognitive impairment with Lewy bodies (MCI-LB) and MCI with Alzheimer’s disease (MCI-AD) and (2) its utility as a potential biomarker for early
Externí odkaz:
https://doaj.org/article/fa6cc008671546c1a51019953d061710
Autor:
Julia Schumacher, Alan J. Thomas, Luis R. Peraza, Michael Firbank, Ruth Cromarty, Calum A. Hamilton, Paul C. Donaghy, John T. O’Brien, John-Paul Taylor
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2020)
Abstract Background Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), is characterised by marked deficits within the cholinergic system which are more severe than in Alzheimer’s disea
Externí odkaz:
https://doaj.org/article/dc299c6c0cc84420ae5fc6f9b428c5e0
Autor:
Julia Schumacher, John-Paul Taylor, Calum A. Hamilton, Michael Firbank, Ruth A. Cromarty, Paul C. Donaghy, Gemma Roberts, Louise Allan, Jim Lloyd, Rory Durcan, Nicola Barnett, John T. O'Brien, Alan J. Thomas
Publikováno v:
NeuroImage: Clinical, Vol 30, Iss , Pp 102604- (2021)
Objectives: To investigate in vivo degeneration of the cholinergic system in mild cognitive impairment with Lewy bodies (MCI-LB), we studied nucleus basalis of Meynert (NBM) volumes from structural MR images and its relation to EEG slowing and cognit
Externí odkaz:
https://doaj.org/article/389e76eaff8945d7ad5edf30f2c4205b
Autor:
Jim J. Lloyd, George Petrides, Paul C. Donaghy, Sean J. Colloby, Johannes Attems, John T. O'Brien, Gemma Roberts, Alan J. Thomas
Publikováno v:
NeuroImage: Clinical, Vol 20, Iss , Pp 823-829 (2018)
Background: Dopaminergic loss on 123I-Ioflupane brain imaging is a recognised biomarker for dementia with Lewy bodies. It is usually assessed using a visual rating scale developed for Parkinson's disease, which may not be optimal for dementia with Le
Externí odkaz:
https://doaj.org/article/d1e4b8c74a364739a3ca77b6c7f4d879
Autor:
Lauren Revie, Calum A Hamilton, Joanna Ciafone, Paul C Donaghy, Alan Thomas, Claudia Metzler-Baddeley
Publikováno v:
Brain Sciences, Vol 10, Iss 8, p 540 (2020)
Background: Visual hallucinations (VH) are a common symptom in dementia with Lewy bodies (DLB); however, their cognitive underpinnings remain unclear. Hallucinations have been related to cognitive slowing in DLB and may arise due to impaired sensory
Externí odkaz:
https://doaj.org/article/f84de73ff0a649d8a865c5a748c735fc
Publikováno v:
Age and Ageing. 50:ii9-ii41
Background Mild cognitive impairment with Lewy bodies (MCI-LB) is the commonest prodromal phenotype of Dementia with Lewy Bodies (DLB) and may be challenging to differentiate from MCI due to Alzheimer’s disease (MCI-AD). Preservation of medial temp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb723a3e7b662e087f6c91805fdc7e8c
https://doi.org/10.1093/ageing/afab219.157
https://doi.org/10.1093/ageing/afab219.157