Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models

Autor: Lorna Hopcroft, Eleanor M. Wigmore, Stuart C. Williamson, Susana Ros, Cath Eberlein, Jennifer I. Moss, Jelena Urosevic, Larissa S. Carnevalli, Sara Talbot, Lauren Bradshaw, Catherine Blaker, Sreeharsha Gunda, Venetia Owenson, Scott Hoffmann, Daniel Sutton, Stewart Jones, Richard J. A. Goodwin, Brandon S. Willis, Claire Rooney, Elza C. de Bruin, Simon T. Barry

Publikováno v: npj Breast Cancer, Vol 9, Iss 1, Pp 1-14 (2023)

Abstract Combining the selective AKT inhibitor, capivasertib, and SERD, fulvestrant improved PFS in a Phase III clinical trial (CAPItello-291), treating HR+ breast cancer patients following aromatase inhibitors, with or without CDK4/6 inhibitors. How

Externí odkaz: https://doaj.org/article/216706db2e6b4b6eae15d98244910c27

Pitfalls in complement analysis: A systematic literature review of assessing complement activation

Autor: Ricardo J. M. G. E. Brandwijk, Marloes A. H. M. Michels, Mara van Rossum, Aline H. de Nooijer, Per H. Nilsson, Wieke C. C. de Bruin, Erik J. M. Toonen

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundThe complement system is an essential component of our innate defense and plays a vital role in the pathogenesis of many diseases. Assessment of complement activation is critical in monitoring both disease progression and response to therap

Externí odkaz: https://doaj.org/article/a2887dc7c436477cbccef38daa8048a3

Human total, basal and activity energy expenditures are independent of ambient environmental temperature

Autor: Xueying Zhang, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Ellen E. Blaak, Maciej S. Buchowski, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Lara R. Dugas, Michael Gurven, Asmaa El Hamdouchi, Sumei Hu, Noorjehan Joonas, Peter Katzmarzyk, William E. Kraus, Robert F. Kushner, William R. Leonard, Corby K. Martin, Erwin P. Meijer, Marian L. Neuhouser, Robert M. Ojiambo, Yannis P. Pitsiladis, Guy Plasqui, Ross L. Prentice, Susan B. Racette, Eric Ravussin, Leanne M. Redman, Rebecca M. Reynolds, Susan B. Roberts, Luis B. Sardinha, Analiza M. Silva, Eric Stice, Samuel S. Urlacher, Edgar A. Van Mil, Brian M. Wood, Alexia J. Murphy-Alford, Cornelia Loechl, Amy H. Luke, Jennifer Rood, Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, Herman Pontzer, John R. Speakman, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issad Baddou, Bedu Addo, Stephane Blanc, Alberto Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Stefan Branth, Niels C. De Bruin, Nancy F. Butte, Lisa H. Colbert, Stephan G. Camps, Alice E. Dutman, Simon D. Eaton, Ulf Ekelund, Sonja Entringer, Cara Ebbeling, Sölve Elmståhl, Mikael Fogelholm, Terrence Forrester, Barry W. Fudge, Tamara Harris, Rik Heijligenberg, Annelies H. Goris, Catherine Hambly, Marije B. Hoos, Hans U. Jorgensen, Annemiek M. Joosen, Kitty P. Kempen, Misaka Kimura, Watanee Kriengsinyos, Estelle V. Lambert, Christel L. Larsson, Nader Lessan, David S. Ludwig, Margaret McCloskey, Anine C. Medin, Gerwin A. Meijer, Eric Matsiko, Alida Melse-Boonstra, James C. Morehen, James P. Morton, Theresa A. Nicklas, Daphne L. Pannemans, Kirsi H. Pietiläinen, Renaat M. Philippaerts, Roberto A. Rabinovich, John J. Reilly, Elisabet M. Rothenberg, Albertine J. Schuit, Sabine Schulz, Anders M. Sjödin, Amy Subar, Minna Tanskanen, Ricardo Uauy, Giulio Valenti, Ludo M. Van Etten, Rita Van den Berg-Emons, Wim G. Van Gemert, Erica J. Velthuis-te Wierik, Wilhelmine W. Verboeket-van de Venne, Jeanine A. Verbunt, Jonathan C.K. Wells, George Wilson

Publikováno v: iScience, Vol 25, Iss 8, Pp 104682- (2022)

Summary: Lower ambient temperature (Ta) requires greater energy expenditure to sustain body temperature. However, effects of Ta on human energetics may be buffered by environmental modification and behavioral compensation. We used the IAEA DLW databa

Externí odkaz: https://doaj.org/article/185d20235c154c7c8514e8e72ad6ab8c

Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers

Autor: Tereza Vaclova, Ursula Grazini, Lewis Ward, Daniel O’Neill, Aleksandra Markovets, Xiangning Huang, Juliann Chmielecki, Ryan Hartmaier, Kenneth S. Thress, Paul D. Smith, J. Carl Barrett, Julian Downward, Elza C. de Bruin

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

A recent clinical trial shows that a proportion of lung cancer patients carrying the EGFR T790M mutation develop resistance to osimertinib. In this study, the authors show that T790M subclonality is associated with worse clinical outcome likely throu

Externí odkaz: https://doaj.org/article/481ad63fcd374f3eb7bb421d24c7891e

Exercise Capacity and Respiratory Profile in Patients after Orthopedic Liver Transplantation: a Follow-up Study

Autor: Clarissa B.A. Magalhães, José Huygens P. Garcia, Cyntia F.G. Viana, Maria José N. Flor, Pedro Felipe C. de Bruin, Eanes D.B. Pereira, Ph.D.

Publikováno v: Annals of Hepatology, Vol 17, Iss 1, Pp 98-103 (2018)

Introduction: We sought to describe: 1) The influence of orthotopic liver transplantation (OLT) on exercise capacity, pulmonary function and respiratory muscle strength after surgery, 2) The relationship between exercise capacity and symptoms of anxi

Externí odkaz: https://doaj.org/article/f6ae89e319034fcbbe965a3f13f86d11