Zobrazeno 1 - 10
of 35
pro vyhledávání: '"P C, Hirom"'
Autor:
M, Imagawa, S, Osada, Y, Koyama, T, Suzuki, P C, Hirom, M B, Diccianni, S, Morimura, M, Muramatsu
Publikováno v:
Biochemical and biophysical research communications. 179(1)
We have previously identified a silencer (negative enhancer) in glutathione transferase P (GST-P) gene which is strongly and specifically induced during hepatocarcinogenesis of the rat. At least three trans-acting factors bind to multiple cis-element
Publikováno v:
Xenobiotica. 8:445-452
1. The pattern of conjugation of phenol and 1-naphthol was investigated in several primates; three Old World species (rhesus, cynomolgus, patas monkeys), two New World species (capuchin, tamarin), and two prosimians (bushbaby, tree shrew). 2. Followi
Publikováno v:
Carcinogenesis. 9:395-398
We have detected glutathione transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene (CDNB) and benzo[a]-pyrene 4,5-oxide (BPO) in freshly isolated peripheral lymphocytes, phytohaemagglutinin (PHA)-stimulated lymphocytes, interleukin-2 (IL-2)-
Publikováno v:
Xenobiotica. 12:397-404
1. Following i.v. administration of [14C]benzo[a]pyrene (3 mumol/kg) to rabbits, 30% of the 14C dose appeared in bile and 12% in urine, within six hours. 2. Biliary and urinary metabolites were mainly conjugated; less than 12% of the 14C was extracta
Publikováno v:
Biochemical Pharmacology. 37:4586-4590
Publikováno v:
Biochemical Society Transactions. 2:327-330
& Patrick, 1969; Horton et al., 1970; Lapey & Gardner, 1971 ; Cole & Dirks, 1972). Glucose uptake by the cystic fibrosis fibroblast is not abnormal (Benke et al., 1972); under the influence of 50pM-ouabain, the decrease in glucose uptake (measured in
Publikováno v:
Xenobiotica. 5:729-739
1. [14C]Prenazone administered to rats (60 mg/kg) as a suspension by stomach tube was excreted to the extent of 43% dose in the urine in 24 h with only 3% in the faeces. After four days the cumulative excretion amounted to 52% in the urine and 15% in
Publikováno v:
Xenobiotica. 10:689-703
1. Biliary elimination in female Wistar albino rats 3 h after i.p. injection of [3H]phenolphthalein, [3H]morphine, 14C-LSD and [14C]diphenylacetic acid was 90%, 45%, 75% and 57% respectively, predominantly as glucuronides. 2. Infusion of 3 h bile fro
Publikováno v:
Biochemical Journal. 153:519-531
Since chlorpromazine hydrochloride [2-chloro-10-(3-dimethylaminopropyl)-phenothiazine hydrochloride] is commonly implicated in causing bile-secretory failure in man and is secreted into bile, we have studied the physicochemical interactions of the dr
Publikováno v:
Biochemical Journal. 129:1071-1077
1. The excretion in the bile and urine after intravenous injection of 16 organic anions having molecular weights between 355 and 752 was studied in female rats, guinea pigs and rabbits. 2. These compounds were mostly excreted unchanged, except for th