Výsledky vyhledávání - "P C, Harkness"

Stable expression of mammalian type A gamma-aminobutyric acid receptors in mouse cells: demonstration of functional assembly of benzodiazepine-responsive sites

Autor: K Quirk, C I Ragan, Eric A. Barnard, P C Harkness, Paul J. Whiting, B. Le Bourdelles, Ruth M. McKernan, K. L. Hadingham, A. L. Horne, John A. Kemp

Publikováno v: Proceedings of the National Academy of Sciences. 89:6378-6382

The differential sensitivity of type A gamma-aminobutyric acid (GABAA) receptors to benzodiazepine ligands seen in the mammalian nervous system is thought to be generated by the existence of a number of different receptor subtypes, assembled from a r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f474aa3ff5906690d76a930a1bb3190e
https://doi.org/10.1073/pnas.89.14.6378

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Influence of the M3-M4 intracellular domain upon nicotinic acetylcholine receptor assembly, targeting and function

Autor: S, Kracun, P C, Harkness, A J, Gibb, N S, Millar

Publikováno v: British journal of pharmacology. 153(7)

The aim of this study was to investigate the influence of the intracellular domain of nicotinic acetylcholine receptor (nAChR) subunits upon receptor assembly, targeting and functional properties.Because most nAChR subunits form functional receptors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2ae5eedcaccbc1b3a172a8660db91b0
https://pubmed.ncbi.nlm.nih.gov/18204482

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Regulation of allosteric coupling and function of stably expressed gamma-aminobutyric acid (GABA)A receptors by chronic treatment with GABAA and benzodiazepine agonists

Autor: R L, Klein, M P, Mascia, P C, Harkness, K L, Hadingham, P J, Whiting, R A, Harris

Publikováno v: The Journal of pharmacology and experimental therapeutics. 274(3)

Chronic treatments with drugs that stimulate or potentiate gamma-aminobutyric acid (GABA)A receptor function cause uncoupling of allosteric sites and downregulation of the GABAA receptors expressed in neurons. To study these effects on receptors havi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77d557f6d166f7cc4c31761ba1a46412
https://pubmed.ncbi.nlm.nih.gov/7562525

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Evidence that CGRP and cAMP increase transcription of AChR alpha-subunit gene, but not of other subunit genes

Autor: E. A. Barnard, P. C. Harkness, Anne W. Mudge, I. J. Mason, Stephen J. Moss

Publikováno v: Journal of molecular neuroscience : MN. 3(2)

Calcitonin gene-related peptide (CGRP) is present in embryonic chick motoneurons and their terminals during myogenesis. We have studied the effect of CGRP on the expression of mRNA encoding the four subunits (alpha, beta, gamma, delta) of ACh recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b1606bf45cf1e80f62397b6c22e92a
https://pubmed.ncbi.nlm.nih.gov/1687655

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