Zobrazeno 1 - 10
of 26
pro vyhledávání: '"P C, Familletti"'
Autor:
S A Tinubu, J Hakimi, J A Kondas, P Bailon, P C Familletti, C Spence, M D Crittenden, G L Parenteau, F M Dirbas, M Tsudo
Publikováno v:
The Journal of Immunology. 153:4330-4338
IL-2Rs are expressed by T cells activated in response to foreign histocompatibility Ags but not by normal cells. This difference in IL-2R expression is exploited by blockade of IL-2Rs to achieve immunosuppression. High affinity IL-2Rs involve three s
Autor:
J Ryan, G Brett, J Kao, Yaping Pan, G Godman, Y G Fan, Feng Wang, P C Familletti, Huan Shen, Jing Xian Chen
Publikováno v:
Journal of Biological Chemistry. 267:20239-20247
An important means by which tumor cells influence the vasculature is through the production of soluble mediators altering vascular properties. A approximately 22-kDa polypeptide was purified to homogeneity from conditioned medium of murine methylchol
Autor:
D S Schoenhaut, A O Chua, A G Wolitzky, P M Quinn, C M Dwyer, W McComas, P C Familletti, M K Gately, U Gubler
Publikováno v:
The Journal of Immunology. 148:3433-3440
Human IL-12 (NK cell stimulatory factor, cytotoxic lymphocyte maturation factor) is a heterodimeric cytokine that can act as a growth factor for activated human T and NK cells, enhance the lytic activity of human NK/lymphokine-activated killer cells,
Autor:
J Hakimi, R Chizzonite, D R Luke, P C Familletti, P Bailon, J A Kondas, R S Pilson, P Lin, D V Weber, C Spence
Publikováno v:
The Journal of Immunology. 147:1352-1359
The anti-Tac mAb has been shown to bind to the p55 chain of the IL-2R, block IL-2 binding and inhibit T cell proliferation. A humanized form of anti-Tac (HAT) has been constructed that retains the binding properties of murine anti-Tac (MAT). These tw
Autor:
M K Gately, B B Desai, A G Wolitzky, P M Quinn, C M Dwyer, F J Podlaski, P C Familletti, F Sinigaglia, R Chizonnite, U Gubler
Publikováno v:
The Journal of Immunology. 147:874-882
IL-12 is a heterodimeric cytokine that was identified on the basis of its ability to synergize with IL-2 in the induction of cytotoxic effector cells and was originally called cytotoxic lymphocyte maturation factor (CLMF). IL-12 was also found to sti
Autor:
Matthias Clauss, P C Familletti, F. Wang, H Gerlach, J Brett, D. T. Connolly, Marlene Gerlach, Y. C.E. Pan, David M. Stern, J. V. Olander
Publikováno v:
The Journal of Experimental Medicine
Systemic infusion of low concentrations of tumor necrosis factor/cachectin (TNF) into mice that bear TNF-sensitive tumors leads to activation of coagulation, fibrin formation, and occlusive thrombosis exclusively within the tumor vascular bed. To ide
Autor:
David M. Stern, R Bach, G Thurston, J C Murray, Peter P. Nawroth, P C Familletti, H Gerlach, R. M. W. De Waal, M Vianna, Matthias Clauss
Publikováno v:
Journal of Biological Chemistry. 265:7078-7083
Intravascular clot formation, localized to the neoplasm, is an early component of the vascular response to tumor necrosis factor (TNF)/cachectin. Fibrin is closely associated with the endothelial cell surface, and multiple microthromboses lead to red
Autor:
S A, Tinubu, J, Hakimi, J A, Kondas, P, Bailon, P C, Familletti, C, Spence, M D, Crittenden, G L, Parenteau, F M, Dirbas, M, Tsudo
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 153(9)
IL-2Rs are expressed by T cells activated in response to foreign histocompatibility Ags but not by normal cells. This difference in IL-2R expression is exploited by blockade of IL-2Rs to achieve immunosuppression. High affinity IL-2Rs involve three s
Autor:
S H, Li, D K, Burns, J M, Rumberger, D H, Presky, V L, Wilkinson, M, Anostario, B A, Wolitzky, C R, Norton, P C, Familletti, K J, Kim
Publikováno v:
The Journal of biological chemistry. 269(6)
To study the structural characteristics of E-selectin necessary for mediating cell adhesion, we examined the role of the consensus repeat (CR) domains in E-selectin function. Soluble constructs containing different numbers of CR domains were stably e
Autor:
J, Kao, J, Ryan, G, Brett, J, Chen, H, Shen, Y G, Fan, G, Godman, P C, Familletti, F, Wang, Y C, Pan
Publikováno v:
The Journal of biological chemistry. 267(28)
An important means by which tumor cells influence the vasculature is through the production of soluble mediators altering vascular properties. A approximately 22-kDa polypeptide was purified to homogeneity from conditioned medium of murine methylchol