Zobrazeno 1 - 10
of 600
pro vyhledávání: '"P C, Bloom"'
Publikováno v:
Vaccines, Vol 12, Iss 7, p 703 (2024)
Vaccination with transiently activated replication-competent controlled herpesviruses (RCCVs) expressing influenza A virus hemagglutinins broadly protects mice against lethal influenza virus challenges. The non-replicating RCCVs can be activated to t
Externí odkaz:
https://doaj.org/article/fef07bb717984e78b291538f98457d32
Publikováno v:
Vaccines, Vol 12, Iss 5, p 537 (2024)
A universal vaccine that generally prevents influenza virus infection and/or illness remains elusive. We have been exploring a novel approach to vaccination involving replication-competent controlled herpesviruses (RCCVs) that can be deliberately act
Externí odkaz:
https://doaj.org/article/143ba12e0ce149d6ae118879d6179ec9
Autor:
James McNulty, Chanti Babu-Dokuburra, Jon Scattolon, Carlos Zepeda-Velazquez, Maribeth A. Wesesky, Jill K. Caldwell, Wenxiao Zheng, Jadranka Milosevic, Paul R. Kinchington, David C. Bloom, Vishwajit L. Nimgaonkar, Leonardo D’Aiuto
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The total synthesis of four novel mono-methoxy and hydroxyl substituted ring-A dihydronarciclasine derivatives enabled identification of the 7-hydroxyl derivative as a potent and selective antiviral agent targeting SARSCoV-2 and HSV-1. The c
Externí odkaz:
https://doaj.org/article/27af499616bc42268d26cedeb59add2c
Autor:
Ana Szarfman, Jonathan G. Levine, Joseph M. Tonning, Frank Weichold, John C. Bloom, Janice M. Soreth, Mark Geanacopoulos, Lawrence Callahan, Matthew Spotnitz, Qin Ryan, Meg Pease-Fye, John S. Brownstein, W. Ed Hammond, Christian Reich, Russ B. Altman
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-7 (2022)
Szarfman et al. discuss the importance of efficient, easy access to large quantities of health data to improve medical care and further medical research. They outline the issues currently experienced accessing and exchanging data in the USA and provi
Externí odkaz:
https://doaj.org/article/23c8b972d7474f6e83a83ac54a0ac7c2
Autor:
Mirna Perusina Lanfranca, Jessica M. van Loben Sels, Cindy Y. Ly, Tristan R. Grams, Adit Dhummakupt, David C. Bloom, David J. Davido
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 4 (2022)
ABSTRACT Herpes simplex virus 1 (HSV-1) is a human pathogen capable of establishing lifelong latent infections that can reactivate under stress conditions. A viral immediate early protein that plays important roles in the HSV-1 lytic and latent infec
Externí odkaz:
https://doaj.org/article/c1e419a7965b431cae287de5ad6ff9d2
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Suppressors of Cytokine Signaling (SOCS) are intracellular proteins that negatively regulate the induction of cytokines. Amongst these, SOCS1 and SOCS3 are particularly involved in inhibition of various interferons. Several viruses have hijacked this
Externí odkaz:
https://doaj.org/article/f14a39f81f2e4ab39fe1516039cbb7dc
Autor:
Leonardo D’Aiuto, Jill K. Caldwell, Callen T. Wallace, Tristan R. Grams, Maribeth A. Wesesky, Joel A. Wood, Simon C. Watkins, Paul R. Kinchington, David C. Bloom, Vishwajit L. Nimgaonkar
Publikováno v:
Cells, Vol 11, Iss 22, p 3539 (2022)
Intrauterine infections during pregnancy by herpes simplex virus (HSV) can cause significant neurodevelopmental deficits in the unborn/newborn, but clinical studies of pathogenesis are challenging, and while animal models can model some aspects of di
Externí odkaz:
https://doaj.org/article/3e1e0d48f52b43589d053a8362073025
Publikováno v:
Viruses, Vol 14, Iss 5, p 1039 (2022)
The dysregulation of host signaling pathways plays a critical role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and viral pathogenesis. While a number of viral proteins that can block type I IFN signaling have been identi
Externí odkaz:
https://doaj.org/article/1461ff9e59634663a298af7856dcbe0c
Autor:
Pankaj Singh, Matthew F. Collins, Richard N. Johns, Kayley A. Manuel, Ziyun A. Ye, David C. Bloom, Donna M. Neumann
Publikováno v:
Viruses, Vol 14, Iss 5, p 909 (2022)
HSV-1 is a human pathogen that establishes a lifelong infection in the host. HSV-1 is transported by retrograde axonal transport to sensory neurons in the peripheral nervous system where latent viral genomes can reactivate. The resulting virus travel
Externí odkaz:
https://doaj.org/article/e3f1c74ba9a34891ba7a347d1edf0339
Autor:
Anja C. Bloom, Lewis H. Bender, Shweta Tiwary, Lise Pasquet, Katharine Clark, Tianbo Jiang, Zheng Xia, Aizea Morales-Kastresana, Jennifer C. Jones, Ian Walters, Masaki Terabe, Jay A. Berzofsky
Publikováno v:
OncoImmunology, Vol 8, Iss 10 (2019)
The benefits of anti-cancer agents extend beyond direct tumor killing. One aspect of cell death is the potential to release antigens that initiate adaptive immune responses. Here, a diffusion enhanced formulation, INT230-6, containing potent anti-can
Externí odkaz:
https://doaj.org/article/fa04e83f4b59444eb2ba3f7c5d829c58