Zobrazeno 1 - 10
of 38
pro vyhledávání: '"P C, Bickford"'
Autor:
Rekha S. Patel, Ashley Lui, Charles Hudson, Lauren Moss, Robert P. Sparks, Shannon E. Hill, Yan Shi, Jianfeng Cai, Laura J. Blair, Paula C. Bickford, Niketa A. Patel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Shifts in normal aging set stage for neurodegeneration and dementia affecting 1 in 10 adults. The study demonstrates that lncRNA GAS5 is decreased in aged and Alzheimer’s disease brain. The role and targets of lncRNA GAS5 in the aging brai
Externí odkaz:
https://doaj.org/article/7e1cfc1749fc453bb56dae844a64cc03
Autor:
Ryan Green, Karthick Mayilsamy, Andrew R. McGill, Taylor E. Martinez, Bala Chandran, Laura J. Blair, Paula C. Bickford, Shyam S. Mohapatra, Subhra Mohapatra
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 217-229 (2022)
The coronavirus disease 2019 (COVID-19) pandemic has caused over 600,000,000 infections globally thus far. Up to 30% of individuals with mild to severe disease develop long COVID, exhibiting diverse neurologic symptoms including dementias. However, t
Externí odkaz:
https://doaj.org/article/f5788a47b7924c8db7fe23ddaa442896
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-16 (2020)
Abstract Background Parkinson’s disease (PD) is the second most prevalent movement disorder characterized by up to 80% loss of dopamine (DA) neurons and accumulation of Lewy body deposits composed of α-synuclein (α-syn). Accumulation of α-syn is
Externí odkaz:
https://doaj.org/article/5449f7022e694aeea53cadd1df8138a9
Autor:
Aimee N. Winter, Meena S. Subbarayan, Bethany Grimmig, Jason A. Weesner, Lauren Moss, Melinda Peters, Edwin Weeber, Kevin Nash, Paula C. Bickford
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Abstract Background Fractalkine (CX3CL1; FKN) is a chemokine expressed by neurons that mediates communication between neurons and microglia. By regulating microglial activity, CX3CL1 can mitigate the damaging effects of chronic microglial inflammatio
Externí odkaz:
https://doaj.org/article/3937848b251241b290cb3d4474efd3d7
Autor:
Chao Ma, Jerry B. Hunt, Andrii Kovalenko, Huimin Liang, Maj-Linda B. Selenica, Michael B. Orr, Bei Zhang, John C. Gensel, David J. Feola, Marcia N. Gordon, Dave Morgan, Paula C. Bickford, Daniel C. Lee
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Brain myeloid cells, include infiltrating macrophages and resident microglia, play an essential role in responding to and inducing neurodegenerative diseases, such as Alzheimer’s disease (AD). Genome-wide association studies (GWAS) implicate many A
Externí odkaz:
https://doaj.org/article/c955b4c995af4d19a154a2fbbbf94d8f
Autor:
Chao Ma, Jerry B. Hunt, Maj-Linda B. Selenica, Awa Sanneh, Leslie A. Sandusky-Beltran, Mallory Watler, Rana Daas, Andrii Kovalenko, Huimin Liang, Devon Placides, Chuanhai Cao, Xiaoyang Lin, Michael B. Orr, Bei Zhang, John C. Gensel, David J. Feola, Marcia N. Gordon, Dave Morgan, Paula C. Bickford, Daniel C. Lee
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Alzheimer’s disease (AD) includes several hallmarks comprised of amyloid-β (Aβ) deposition, tau neuropathology, inflammation, and memory impairment. Brain metabolism becomes uncoupled due to aging and other AD risk factors, which ultimately lead
Externí odkaz:
https://doaj.org/article/eb73ef7b7394472091f6f6e6c914d923
Autor:
Niketa A. Patel, Lauren Daly Moss, Jea-Young Lee, Naoki Tajiri, Sandra Acosta, Charles Hudson, Sajan Parag, Denise R. Cooper, Cesario V. Borlongan, Paula C. Bickford
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-23 (2018)
Abstract Background Neuroinflammation is a common therapeutic target for traumatic brain injury (TBI) due to its contribution to delayed secondary cell death and has the potential to occur for years after the initial insult. Exosomes from adipose-der
Externí odkaz:
https://doaj.org/article/cb14cbfcc37a4e88b082eb6ac062e094
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-15 (2017)
Abstract Background Age is the primary risk factor for many diseases. As such, age is a critical co-factor for examination in order to understand the progression and potential intervention in disease progression. Studies examining both the phenotype
Externí odkaz:
https://doaj.org/article/7675f7b616d94c01b7f3c4a757bd36b0
Autor:
Aimee N. Winter, Paula C. Bickford
Publikováno v:
Antioxidants, Vol 8, Iss 9, p 333 (2019)
Neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS), are characterized by the death of neurons within specific regions of the brain or spinal cord. While the etiology of many neu
Externí odkaz:
https://doaj.org/article/a30a95e2a40a457d9f841c543a81ea62
Autor:
Jingji Jin, Bethany Grimmig, James Izzo, Lecia A. M. Brown, Charles Hudson, Adam J. Smith, Jun Tan, Paula C. Bickford, Brian Giunta
Publikováno v:
Cell Transplantation, Vol 25 (2016)
The prevalence of HIV-associated neurocognitive disorders (HAND) remains high despite combination antiretroviral therapy (cART). There is evidence that neural stem cells (NSCs) can migrate to sites of brain injury such as those caused by inflammation
Externí odkaz:
https://doaj.org/article/7575eeeb75674a98834e1bfb4e3a79f6