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Akademický článek
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Autor:
K. Ahuja, M. Vandenabeele, F. Nami, E. Lefevere, J. Van hoecke, S. Bergmans, M. Claes, T. Vervliet, K. Neyrinck, T. Burg, D. De Herdt, P. Bhaskar, Y. Zhu, Z. J. Looser, J. Loncke, W. Gsell, M. Plaas, P. Agostinis, J. V. Swinnen, L. Van Den Bosch, G. Bultynck, A. S. Saab, E. Wolfs, Y. C. Chai, U. Himmelreich, C. Verfaillie, L. Moons, L. De Groef
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-23 (2024)
Abstract Wolfram syndrome (WS) is a rare childhood disease characterized by diabetes mellitus, diabetes insipidus, blindness, deafness, neurodegeneration and eventually early death, due to autosomal recessive mutations in the WFS1 (and WFS2) gene. Wh
Externí odkaz:
https://doaj.org/article/1fc5ac8a195045e784ceddeab1da8565
Autor:
Rudy Gadet, Lea Jabbour, Trang Thi Minh Nguyen, Olivier Lohez, Ivan Mikaelian, Philippe Gonzalo, Tomas Luyten, Mounira Chalabi-Dchar, Anne Wierinckx, Olivier Marcillat, Geert Bultynck, Ruth Rimokh, Nikolay Popgeorgiev, Germain Gillet
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Apoptosis plays a role in cell homeostasis in both normal development and disease. Bcl-xL, a member of the Bcl-2 family of proteins, regulates the intrinsic mitochondrial pathway of apoptosis. It is overexpressed in several cancers. Bcl-xL h
Externí odkaz:
https://doaj.org/article/34c348a12fb44ef2916bea077f155ce7
Autor:
Mailis Liiv, Annika Vaarmann, Dzhamilja Safiulina, Vinay Choubey, Ruby Gupta, Malle Kuum, Lucia Janickova, Zuzana Hodurova, Michal Cagalinec, Akbar Zeb, Miriam A. Hickey, Yi-Long Huang, Nana Gogichaishvili, Merle Mandel, Mario Plaas, Eero Vasar, Jens Loncke, Tim Vervliet, Ting-Fen Tsai, Geert Bultynck, Vladimir Veksler, Allen Kaasik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Wolfram syndrome is a rare genetic disease caused by mutations in the WFS1 or CISD2 gene. A primary defect in Wolfram syndrome involves poor ER Ca2+ handling, but how this disturbance leads to the disease is not known. The current study, per
Externí odkaz:
https://doaj.org/article/7119060b6c6844ed9cd995417943a2ed
Autor:
Femke Speelman-Rooms, Maarten Vanmunster, Aled Coughlan, Macarena Hinrichs, Ilaria Pontisso, Solene Barbeau, Thibaud Parpaite, Geert Bultynck, Malene Brohus
Publikováno v:
Biology Open, Vol 13, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/9ad6160f44444596878e299143f724e9
Autor:
Bouquin, Paul, Kim, Joo-Von, Bultynck, Olivier, Rao, Siddharth, Couet, Sebastien, Kar, Gouri Sankar, Devolder, Thibaut
Publikováno v:
Phys. Rev. B 103, 224431 (2021)
We use time-resolved measurement and modeling to study the spin-torque induced motion of a domain wall in perpendicular anisotropy magnets. In disc of diameters between 70 and 100 nm, the wall drifts across the disc with pronounced back-and-forth osc
Externí odkaz:
http://arxiv.org/abs/2104.10929
Autor:
Margot Van Daele, Yannick Smolders, Dorine Van Loo, Charlotte Bultynck, Johan Verbraecken, Anneclaire Vroegop, Thérèse Lapperre, Sara Op de Beeck, Marijke Dieltjens, Olivier M. Vanderveken
Publikováno v:
Life, Vol 14, Iss 8, p 1007 (2024)
Obstructive sleep apnea (OSA) is a sleep disorder characterized by repetitive episodes of partial or complete obstruction of the upper airway during sleep. Continuous positive airway pressure (CPAP) is a method used as a first-line treatment for obst
Externí odkaz:
https://doaj.org/article/475bc6f606ba40d9b6e5fa618568b221
Autor:
Flore Sneyers, Martijn Kerkhofs, Femke Speelman-Rooms, Kirsten Welkenhuyzen, Rita La Rovere, Ahmed Shemy, Arnout Voet, Guy Eelen, Mieke Dewerchin, Stephen W. G. Tait, Bart Ghesquière, Martin D. Bootman, Geert Bultynck
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-17 (2023)
Abstract Intracellular Ca2+ signals control several physiological and pathophysiological processes. The main tool to chelate intracellular Ca2+ is intracellular BAPTA (BAPTAi), usually introduced into cells as a membrane-permeant acetoxymethyl ester
Externí odkaz:
https://doaj.org/article/165f5a0201694ead8a06898f90b65886
Autor:
Elżbieta Kania, Jaclyn S. Long, David G. McEwan, Kirsten Welkenhuyzen, Rita La Rovere, Tomas Luyten, John Halpin, Evy Lobbestael, Veerle Baekelandt, Geert Bultynck, Kevin M. Ryan, Jan B. Parys
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-14 (2023)
Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson’s disease (PD), with growing importance also for Crohn’s disease and cancer. LRRK2 is a large and complex protein possessing both G
Externí odkaz:
https://doaj.org/article/ac990b44ebe440e7985118a7bf10125c
Autor:
Bouquin, Paul, Kim, Joo-Von, Bultynck, Olivier, Rao, Siddharth, Couet, Sebastien, Kar, Gouri Sankar, Devolder, Thibaut
Publikováno v:
Phys. Rev. Applied 15, 024037 (2021)
We show experimentally through time-resolved conductance measurements that magnetization reversal through domain wall motion in sub-100 nm diameter magnetic tunnel junctions is dominated by two distinct stochastic effects. The first involves the incu
Externí odkaz:
http://arxiv.org/abs/2009.07492