Zobrazeno 1 - 10
of 110
pro vyhledávání: '"P Bryant Chase"'
Autor:
Maicon Landim-Vieira, Matthew C Childers, Amanda L Wacker, Michelle Rodriquez Garcia, Huan He, Rakesh Singh, Elizabeth A Brundage, Jamie R Johnston, Bryan A Whitson, P Bryant Chase, Paul ML Janssen, Michael Regnier, Brandon J Biesiadecki, J Renato Pinto, Michelle S Parvatiyar
Publikováno v:
eLife, Vol 11 (2022)
Phosphorylation and acetylation of sarcomeric proteins are important for fine-tuning myocardial contractility. Here, we used bottom-up proteomics and label-free quantification to identify novel post-translational modifications (PTMs) on β-myosin hea
Externí odkaz:
https://doaj.org/article/38e39ac9728c48009835c5d2747080b4
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164222 (2016)
Cardiac troponin C (cTnC) is a key effector in cardiac muscle excitation-contraction coupling as the Ca2+ sensing subunit responsible for controlling contraction. In this study, we generated several FRET sensors for divalent cations based on cTnC fla
Externí odkaz:
https://doaj.org/article/038d79cc8b144263a843d331a3061fee
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39676 (2012)
α-Tropomyosin (αTm) is the predominant tropomyosin isoform in adult human heart and constitutes a major component in Ca²+-regulated systolic contraction of cardiac muscle. We present here the first direct probe images of WT human cardiac αTm by a
Externí odkaz:
https://doaj.org/article/8c160f0f0a0a49f295218cc63c21bcb0
Autor:
Cristina M Risi, Betty Belknap, Howard D White, Kelly Dryden, Jose R Pinto, P Bryant Chase, Vitold E Galkin
Publikováno v:
PNAS Nexus. 2
Cardiac contraction depends on molecular interactions among sarcomeric proteins coordinated by the rising and falling intracellular Ca2+ levels. Cardiac thin filament (cTF) consists of two strands composed of actin, tropomyosin (Tm), and equally spac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fa409e56284d5d6fef73a62a214c5ad
https://doi.org/10.1093/pnasnexus/pgac298
https://doi.org/10.1093/pnasnexus/pgac298
Autor:
Maicon Landim-Vieira, Jose R. Pinto, Bin Sun, Elio A. Cino, Isela C. Valera, Peter M. Kekenes-Huskey, Karissa M. Dieseldorff Jones, Jamie R. Johnston, Adolfo H. Moraes, Michelle S. Parvatiyar, Jerson L. Silva, Guilherme A. P. de Oliveira, Vitold E. Galkin, P. Bryant Chase, Mayra A. Marques
Publikováno v:
Chemical Science
Cardiac TnC (cTnC) is highly conserved among mammals, and genetic variants can result in disease by perturbing Ca2+-regulation of myocardial contraction. Here, we report the molecular basis of a human mutation in cTnC's αD-helix (TNNC1-p.C84Y) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076a706144f657ad43c53f2d9b5ca239
https://doi.org/10.1039/d1sc01886h
https://doi.org/10.1039/d1sc01886h
Autor:
Jamie R. Johnston, Paul M.L. Janssen, Michelle Rodriquez Garcia, Rakesh K. Singh, Michelle S. Parvatiyar, Jose R. Pinto, Matthew C. Childers, Huan He, Elizabeth A. Brundage, Michael Regnier, Brandon J. Biesiadecki, Amanda L. Wacker, Maicon Landim-Vieira, P. Bryant Chase, Bryan A Whitson
Publikováno v:
eLife. 11
Phosphorylation and acetylation of sarcomeric proteins are important for fine-tuning myocardial contractility. Here, we used bottom-up proteomics and label-free quantification to identify novel post-translational modifications (PTMs) on beta-myosin h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057c9917b0b31456add3a2f0150ba929
https://doi.org/10.7554/elife.74919
https://doi.org/10.7554/elife.74919
Autor:
Matthew C Childers, Maicon Landim-Vieira, Amanda L Wacker, Michelle Rodriquez Garcia, Huan He, Rakesh Singh, Elizabeth A Brundage, Jamie R Johnston, Bryan A Whitson, P Bryant Chase, Paul ML Janssen, Michael Regnier, Brandon J Biesiadecki, J Renato Pinto, Michelle S Parvatiyar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f6ab252d259d6b6560c3dc9aa340bf4
https://doi.org/10.7554/elife.74919.sa2
https://doi.org/10.7554/elife.74919.sa2
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2020 (2020)
BioMed Research International, Vol 2020 (2020)
ELABELA (ELA) is considered to be implicated in the pathophysiology of preeclampsia (PE), since ELA-deficient mice exhibited PE-like symptoms and infusion of exogenous ELA normalized the gestational hypertension (GH) and proteinuria. However, no evid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ffded0e56e0de7d4ce36a66a8931d0
https://doi.org/10.1155/2020/2051701
https://doi.org/10.1155/2020/2051701
Autor:
Paula F. Nieto Morales, Isabella Coscarella, Emily Farrar, Nikita Zalenski, Maicon Landim-Vieira, P. Bryant Chase, Jose R. Pinto
Publikováno v:
Biophysical Journal. 122:384a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6d0893843538534bfc9ea38d6dbdbf6
https://doi.org/10.1016/j.bpj.2022.11.2104
https://doi.org/10.1016/j.bpj.2022.11.2104
Autor:
Huan He, Anwar Iqbal, Einat Birk, David Gonzalez-Martinez, Maicon Landim-Vieira, Mayra A. Marques, Jerson L. Silva, Yael Wilnai, Jose R. Pinto, P. Bryant Chase, Jamie R. Johnston, Adolfo H. Moraes, Guilherme A. P. de Oliveira, Nili Zucker
Publikováno v:
Repositório Institucional da UFMG
Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
J Biol Chem
Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
J Biol Chem
Aberrant regulation of myocardial force production represents an early biomechanical defect associated with sarcomeric cardiomyopathies, but the molecular mechanisms remain poorly defined. Here, we evaluated the pathogenicity of a previously unreport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e07f40bd697a82c4660495e0839d7bd
https://doi.org/10.1074/jbc.ra119.011177
https://doi.org/10.1074/jbc.ra119.011177