Zobrazeno 1 - 10
of 337
pro vyhledávání: '"P Bryant Chase"'
Autor:
Maicon Landim-Vieira, Matthew C Childers, Amanda L Wacker, Michelle Rodriquez Garcia, Huan He, Rakesh Singh, Elizabeth A Brundage, Jamie R Johnston, Bryan A Whitson, P Bryant Chase, Paul ML Janssen, Michael Regnier, Brandon J Biesiadecki, J Renato Pinto, Michelle S Parvatiyar
Publikováno v:
eLife, Vol 11 (2022)
Phosphorylation and acetylation of sarcomeric proteins are important for fine-tuning myocardial contractility. Here, we used bottom-up proteomics and label-free quantification to identify novel post-translational modifications (PTMs) on β-myosin hea
Externí odkaz:
https://doaj.org/article/38e39ac9728c48009835c5d2747080b4
Autor:
Karissa M. Dieseldorff Jones, Cynthia Vied, Isela C. Valera, P. Bryant Chase, Michelle S. Parvatiyar, Jose R. Pinto
Publikováno v:
Physiological Reports, Vol 8, Iss 6, Pp n/a-n/a (2020)
Abstract Heart disease remains the number one killer of women in the US. Nonetheless, studies in women and female animal models continue to be underrepresented in cardiac research. Hypertrophic cardiomyopathy (HCM), the most commonly inherited cardia
Externí odkaz:
https://doaj.org/article/49c6220b518f40c3bab41f6ad3913973
Autor:
Maicon Landim-Vieira, Jamie R. Johnston, Weizhen Ji, Emily K. Mis, Joshua Tijerino, Michele Spencer-Manzon, Lauren Jeffries, E. Kevin Hall, David Panisello-Manterola, Mustafa K. Khokha, Engin Deniz, P. Bryant Chase, Saquib A. Lakhani, Jose Renato Pinto
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
Familial dilated cardiomyopathy (DCM), clinically characterized by enlargement and dysfunction of one or both ventricles of the heart, can be caused by variants in sarcomeric genes including TNNC1 (encoding cardiac troponin C, cTnC). Here, we report
Externí odkaz:
https://doaj.org/article/d54c1495d9574db285c1dbf940168414
Akademický článek
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Autor:
Cristina M Risi, Betty Belknap, Howard D White, Kelly Dryden, Jose R Pinto, P Bryant Chase, Vitold E Galkin
Publikováno v:
PNAS Nexus. 2
Cardiac contraction depends on molecular interactions among sarcomeric proteins coordinated by the rising and falling intracellular Ca2+ levels. Cardiac thin filament (cTF) consists of two strands composed of actin, tropomyosin (Tm), and equally spac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fa409e56284d5d6fef73a62a214c5ad
https://doi.org/10.1093/pnasnexus/pgac298
https://doi.org/10.1093/pnasnexus/pgac298
Autor:
Jose R. Pinto, Tiago Veltri, Maicon Landim-Vieira, Michelle S. Parvatiyar, David Gonzalez-Martinez, Karissa M. Dieseldorff Jones, Clara A. Michell, David Dweck, Andrew P. Landstrom, P. Bryant Chase
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Mutations in TNNC1—the gene encoding cardiac troponin C (cTnC)—that have been associated with hypertrophic cardiomyopathy (HCM) and cardiac dysfunction may also affect Ca2+-regulation and function of slow skeletal muscle since the same gene is ex
Externí odkaz:
https://doaj.org/article/de0f01d82986440e8a1a28beedc74a76
Publikováno v:
Journal of Aging Research, Vol 2017 (2017)
Background. Obesity, osteoporosis, and sarcopenia may individually occur due to age-related gradual alterations in body composition. This study investigates the cooccurrence of these age-related diseases in female animals with low levels of ovarian h
Externí odkaz:
https://doaj.org/article/3af5329a82ab4f469540b672c182c351
Autor:
Maicon Landim-Vieira, Jose R. Pinto, Bin Sun, Elio A. Cino, Isela C. Valera, Peter M. Kekenes-Huskey, Karissa M. Dieseldorff Jones, Jamie R. Johnston, Adolfo H. Moraes, Michelle S. Parvatiyar, Jerson L. Silva, Guilherme A. P. de Oliveira, Vitold E. Galkin, P. Bryant Chase, Mayra A. Marques
Publikováno v:
Chemical Science
Cardiac TnC (cTnC) is highly conserved among mammals, and genetic variants can result in disease by perturbing Ca2+-regulation of myocardial contraction. Here, we report the molecular basis of a human mutation in cTnC's αD-helix (TNNC1-p.C84Y) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076a706144f657ad43c53f2d9b5ca239
https://doi.org/10.1039/d1sc01886h
https://doi.org/10.1039/d1sc01886h
Autor:
Jamie R. Johnston, Paul M.L. Janssen, Michelle Rodriquez Garcia, Rakesh K. Singh, Michelle S. Parvatiyar, Jose R. Pinto, Matthew C. Childers, Huan He, Elizabeth A. Brundage, Michael Regnier, Brandon J. Biesiadecki, Amanda L. Wacker, Maicon Landim-Vieira, P. Bryant Chase, Bryan A Whitson
Publikováno v:
eLife. 11
Phosphorylation and acetylation of sarcomeric proteins are important for fine-tuning myocardial contractility. Here, we used bottom-up proteomics and label-free quantification to identify novel post-translational modifications (PTMs) on beta-myosin h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057c9917b0b31456add3a2f0150ba929
https://doi.org/10.7554/elife.74919
https://doi.org/10.7554/elife.74919
Autor:
Matthew C Childers, Maicon Landim-Vieira, Amanda L Wacker, Michelle Rodriquez Garcia, Huan He, Rakesh Singh, Elizabeth A Brundage, Jamie R Johnston, Bryan A Whitson, P Bryant Chase, Paul ML Janssen, Michael Regnier, Brandon J Biesiadecki, J Renato Pinto, Michelle S Parvatiyar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f6ab252d259d6b6560c3dc9aa340bf4
https://doi.org/10.7554/elife.74919.sa2
https://doi.org/10.7554/elife.74919.sa2
