Zobrazeno 1 - 10
of 66
pro vyhledávání: '"P B Sehgal"'
Publikováno v:
Cells, Vol 13, Iss 7, p 590 (2024)
The oral mucosa represents a defensive barrier between the external environment and the rest of the body. Oral mucosal cells are constantly bathed in hypotonic saliva (normally one-third tonicity compared to plasma) and are repeatedly exposed to envi
Externí odkaz:
https://doaj.org/article/8fcf325049df4900bfeacf3e7a67d4a4
Autor:
Pravin B. Sehgal
Publikováno v:
Contemporary Oncology, Vol 23, Iss 1, Pp 16-22 (2019)
We highlight previous incompletely understood cell biology data in the STAT3 signaling field with respect to interleukin-6 (IL-6)-induced activation of this transcription factor in hepatoma cells to generate cytoplasmic and nuclear STAT3 bodies. We p
Externí odkaz:
https://doaj.org/article/dc42e4097c0e48aea101f1ca6094ac00
Autor:
Pravin B. Sehgal
Publikováno v:
Cells, Vol 11, Iss 7, p 1164 (2022)
It was recognized over 30 years ago that the polyfunctional cytokine interleukin-6 (IL-6) was an almost invariant presence at the host-tumor interface. The IL-6 in the tumor microenvironment was produced either by the cancer cell or by host stromal c
Externí odkaz:
https://doaj.org/article/ed38f61b9a534123a49f8a2522cc9443
Autor:
Huijuan Yuan, Pravin B Sehgal
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166382 (2016)
There is confusion about the role that IFN-α plays in the pathogenesis of pulmonary arterial hypertension (PAH) with different investigators reporting a causative or a protective role. There is now clear evidence in PAH pathogenesis for the involvem
Externí odkaz:
https://doaj.org/article/89cd7bcb26894fbd9749103699f42ffe
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55426 (2013)
The transcription factor STAT3 has been previously reported to be associated with mitochondria. However, we have been unable to visualize an association of STAT3-GFP, STAT3-DsRed or STAT3-Flag with mitochondria in human Hep3B hepatocytes thus far eve
Externí odkaz:
https://doaj.org/article/df1a471a44f948af8a7368745310ae0e
Publikováno v:
Journal of Maternal-Fetal and Neonatal Medicine. 10:155-158
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e33c5dc462e0a760b34b42c10493a293
https://doi.org/10.1080/jmf.10.3.155.158
https://doi.org/10.1080/jmf.10.3.155.158
Autor:
E A Havell, P B Sehgal
Publikováno v:
The Journal of Immunology. 146:756-761
We report that TNF, IL-6, and IFN-alpha/beta are produced by mice during either sublethal or lethal Listeria monocytogenes infections. The quantities of these cytokines in infected spleens increase and decrease in concordance with bacterial numbers i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16bd04338679e22b8e35a27cb5f51b0c
https://doi.org/10.4049/jimmunol.146.2.756
https://doi.org/10.4049/jimmunol.146.2.756
Publikováno v:
The Journal of Immunology. 145:1337-1342
IL-6 is a multifunctional cytokine which is produced by a variety of cells. Therefore it was examined whether anti-CD3-induced T cell activation was associated with the induction of functionally relevant IL-6 in human monocyte accessory cells. Signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2fc05ed8f81c7a94211b7174db43d1b
https://doi.org/10.4049/jimmunol.145.5.1337
https://doi.org/10.4049/jimmunol.145.5.1337
Publikováno v:
Journal of Clinical Investigation. 85:1392-1400
To evaluate whether IL-6 participates in the host response to intrauterine infection, we studied IL-6 bioactivity and isoforms in amniotic fluid (AF). Two different assays for IL-6 were used: the hepatocyte stimulating factor assay (in Hep3B2 cells)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4089502f70e95421221ac1aaabf25d
https://doi.org/10.1172/jci114583
https://doi.org/10.1172/jci114583