Zobrazeno 1 - 10
of 125
pro vyhledávání: '"P B Molinoff"'
Publikováno v:
Circulation Research. 69:1546-1556
Changes in the beta-adrenergic receptor-G protein-adenylate cyclase complex were investigated in an experimental canine model of low-output heart failure produced by chronic rapid ventricular pacing. The contractile response occurring after exposure
Publikováno v:
Advances in pharmacology (San Diego, Calif.). 42
Publikováno v:
Molecular pharmacology. 50(3)
Antisense oligodeoxynucleotides were used to determine whether alterations in the expression of N-methyl-D-aspartate (NMDA) receptor subunit mRNA are responsible for developmental changes in the sensitivity of receptors to agonists and antagonists. X
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 276(2)
By using a baculovirus expression system, the two isoforms of the rat D2 dopamine receptor were expressed at densities ranging up to 15 pmol/mg of protein. D2L and D2S dopamine receptors expressed in aline of Spodoptera frugiperda (Sf9) insect cells
Publikováno v:
Molecular pharmacology. 48(5)
Studies with radiolabeled antagonists have revealed that both agonists and antagonists induce up-regulation of D2 dopamine receptors in cells transfected to express D2L or D2S receptors. The regulation induced by agonists, but not antagonists, was sy
Autor:
P, Butkerait, Y, Zheng, H, Hallak, T E, Graham, H A, Miller, K D, Burris, P B, Molinoff, D R, Manning
Publikováno v:
The Journal of biological chemistry. 270(31)
The possibility that Spodoptera frugiperda (Sf9) cells can provide an intact cell setting for reconstitution of the human 5-hydroxytryptamine1A (5-HT1A) receptor with mammalian G protein subunits was explored. The 5-HT1A receptor was found to assume
Publikováno v:
The Journal of biological chemistry. 269(50)
Exposure of P11 cells to serotonin (5-HT) resulted in a transient increase in levels of 5-HT2A receptor mRNA. Exposure to 5-HT for as short a time as 1 min was sufficient to trigger a delayed increase in receptor mRNA. 5-HT-induced increases in recep
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 271(3)
Mechanisms underlying agonist- and antagonist-induced up-regulation in HEK-293 cells transfected to express D2 dopamine receptors were investigated. We have reported previously that exposure of cells to agonists and antagonists led to an increase in
Autor:
D B, Bylund, D C, Eikenberg, J P, Hieble, S Z, Langer, R J, Lefkowitz, K P, Minneman, P B, Molinoff, R R, Ruffolo, U, Trendelenburg
Publikováno v:
Pharmacological reviews. 46(2)
Publikováno v:
Molecular pharmacology. 45(5)
The endogenous polyamine spermine has multiple effects on the N-methyl-D-aspartate (NMDA) receptor. These include an increase in the magnitude of NMDA-induced whole-cell currents that is seen in the presence of saturating concentrations of glycine ("