Zobrazeno 1 - 10
of 10
pro vyhledávání: '"P B Melhuish"'
Publikováno v:
Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury ISBN: 9781461367277
The cyclo-oxygenase inhibitor indomethacin exerts an anticancer effect on mouse NC tumours (1). Since prostaglandins (PGs) can depress the immune response (2), indomethacin might act by suppressing a PG-mediated depression of the host response. We th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f366ad778a589d515e60c5df6eb6ea1
https://doi.org/10.1007/978-1-4615-3874-5_54
https://doi.org/10.1007/978-1-4615-3874-5_54
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 5(2)
Parietal bones from 2-week-old rats were dissected free from the sutural regions, dura mater, and periosteum, leaving the surface covered with osteoblasts and some osteoclasts. Prostaglandin (PG) production by these "stripped" bones under basal condi
Publikováno v:
British Journal of Cancer
WHT/Ht mice transplanted s.c. with NC carcinoma were treated with 16,16-dimethyl prostaglandin E2 methyl ester (di-me-PGE2) and/or indomethacin. Each primary tumour was excised under anaesthesia 3 weeks after transplantation, weighed and extracted fo
Publikováno v:
British Journal of Pharmacology. 91:229-235
The effect of indomethacin on the response of the NC carcinoma to methotrexate has been examined in vivo and in vitro. Survival was prolonged in mice treated with indomethacin 1.25 mg kg-1 twice daily plus methotrexate 4 mg kg-1 daily, compared to mi
Publikováno v:
Gut. 28:315-318
This is the first report of human gastrointestinal arachidonate and prostanoids measured quantitatively by gas chromatography-mass spectrometry (GC-MS) in extracts of human cancers and macroscopically normal tissues from the stomach and colon. There
Publikováno v:
Journal of Pharmacy and Pharmacology. 39:1039-1041
The question of whether vasodilator nitrates act by releasing prostacyclin is controversial. Since the ability of blood vessels to form prostacyclin changes with age, we have investigated whether this may explain the discrepancies in the literature.
Publikováno v:
British Journal of Pharmacology. 86:693-695
Rats were given either carbenoxolone 50 mg kg-1, deglycyrrhized liquorice 1 g kg-1 or vehicle by gastric tube. The doses were repeated 16 h later, and the stomachs removed after another 2 h. The amounts of prostaglandin E (PGE), 6-keto-PGF1 alpha and
Publikováno v:
Advances in prostaglandin, thromboxane, and leukotriene research.
Publikováno v:
Prostaglandin and Lipid Metabolism in Radiation Injury ISBN: 9781468454598
Since eicosanoids may influence tumor growth and spread and radiotherapy can increase tissue prostaglandins, it is important to investigate relationships between prostaglandins and radiotherapy in cancer. Our studies in mice with NC carcinoma show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::601ae9c0cf28b5766ef7341d30c3231a
https://doi.org/10.1007/978-1-4684-5457-4_33
https://doi.org/10.1007/978-1-4684-5457-4_33
Autor:
I. F. Stamford, I A Tavares, S. Morgan, P B Melhuish, Alan Bennett, J. A. Brown, Nicola Mascolo
Publikováno v:
Proceedings in Life Sciences ISBN: 9783642719066
The anti-oestrogen tamoxifen increases the survival of breast cancer patients by 20% over a 6-year period (Nolvadex adjuvant trial organization, 1985). Although tamoxifen is thought to act via oestrogen receptors, some patients with oestrogen-recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dda805da12cc70e27f54c7b684e162ae
https://doi.org/10.1007/978-3-642-71904-2_26
https://doi.org/10.1007/978-3-642-71904-2_26