Zobrazeno 1 - 10
of 34
pro vyhledávání: '"P B McCulloch"'
Autor:
Stephen J. Bush, Mary E. B. McCulloch, Charity Muriuki, Mazdak Salavati, Gemma M. Davis, Iseabail L. Farquhar, Zofia M. Lisowski, Alan L. Archibald, David A. Hume, Emily L. Clark
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 2, Pp 359-373 (2019)
One of the most significant physiological challenges to neonatal and juvenile ruminants is the development and establishment of the rumen. Using a subset of RNA-Seq data from our high-resolution atlas of gene expression in sheep (Ovis aries) we have
Externí odkaz:
https://doaj.org/article/73da7c1940804333b770fb689ad6c742
Autor:
Stephen J. Bush, Mary E. B. McCulloch, Zofia M. Lisowski, Charity Muriuki, Emily L. Clark, Rachel Young, Clare Pridans, James G. D. Prendergast, Kim M. Summers, David A. Hume
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Mammalian macrophages differ in their basal gene expression profiles and response to the toll-like receptor 4 (TLR4) agonist, lipopolysaccharide (LPS). In human macrophages, LPS elicits a temporal cascade of transient gene expression including feed f
Externí odkaz:
https://doaj.org/article/2feec44cf1d94bef811f6000160a277c
Autor:
Stephen J. Bush, Charity Muriuki, Mary E. B. McCulloch, Iseabail L. Farquhar, Emily L. Clark, David A. Hume
Publikováno v:
Genetics Selection Evolution, Vol 50, Iss 1, Pp 1-17 (2018)
Abstract Background mRNA-like long non-coding RNAs (lncRNAs) are a significant component of mammalian transcriptomes, although most are expressed only at low levels, with high tissue-specificity and/or at specific developmental stages. Thus, in many
Externí odkaz:
https://doaj.org/article/c7a125ad71fb4043a8ac8a2e833e4802
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-12 (2017)
Abstract Background The availability of fast alignment-free algorithms has greatly reduced the computational burden of RNA-seq processing, especially for relatively poorly assembled genomes. Using these approaches, previous RNA-seq datasets could pot
Externí odkaz:
https://doaj.org/article/f110f059052f4315bd770c0ec0b5b1a2
Autor:
Mazdak Salavati, Stephen J. Bush, Sergio Palma-Vera, Mary E. B. McCulloch, David A. Hume, Emily L. Clark
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Pervasive allelic variation at both gene and single nucleotide level (SNV) between individuals is commonly associated with complex traits in humans and animals. Allele-specific expression (ASE) analysis, using RNA-Seq, can provide a detailed annotati
Externí odkaz:
https://doaj.org/article/b9890256ec5b4cf08a7109584a946956
Autor:
Lindsey A. Waddell, Lucas Lefevre, Stephen J. Bush, Anna Raper, Rachel Young, Zofia M. Lisowski, Mary E. B. McCulloch, Charity Muriuki, Kristin A. Sauter, Emily L. Clark, Katharine M. Irvine, Clare Pridans, Jayne C. Hope, David A. Hume
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The F4/80 antigen, encoded by the Adgre1 locus, has been widely-used as a monocyte-macrophage marker in mice, but its value as a macrophage marker in other species is unclear, and has even been questioned. ADGRE1 is a seven transmembrane G protein-co
Externí odkaz:
https://doaj.org/article/33331c1ac13b4df3886ab0ab2aa93642
Autor:
Emily L Clark, Stephen J Bush, Mary E B McCulloch, Iseabail L Farquhar, Rachel Young, Lucas Lefevre, Clare Pridans, Hiu G Tsang, Chunlei Wu, Cyrus Afrasiabi, Mick Watson, C Bruce Whitelaw, Tom C Freeman, Kim M Summers, Alan L Archibald, David A Hume
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1006997 (2017)
Sheep are a key source of meat, milk and fibre for the global livestock sector, and an important biomedical model. Global analysis of gene expression across multiple tissues has aided genome annotation and supported functional annotation of mammalian
Externí odkaz:
https://doaj.org/article/a0ea1d80013b4ca2af1864599c927f7c
Publikováno v:
Marine Drugs, Vol 10, Iss 8, Pp 1711-1728 (2012)
Pseudopterosins and pseudopteroxazole are intriguing marine natural products that possess notable antimicrobial activity with a commensurate lack of cytotoxicity. New semi-synthetic pseudopteroxazoles, pseudopteroquinoxalines and pseudopterosin conge
Externí odkaz:
https://doaj.org/article/a4679633c42d41b7b639d8e48ae0a639
Autor:
R. H. Wilkinson, P. B. Mcculloch, L. J. Mahoney, Mark Levine, Roy M. Clark, Andrew R. Willan, Robin S. Roberts, M. Lipa, Timothy J. Whelan
Publikováno v:
JNCI Journal of the National Cancer Institute. 88:1659-1664
Background: Breast-conservation surgery is now commonly used to treat breast cancer. Postoperative breast irradiation reduces cancer recurrence in the breast. There is still controversy concerning the necessity of irradiation of the breast in all pat
Autor:
H. K. B. Silver, Ian Quirt, P. B. Mcculloch, J. Pater, R Prentice, Andrew R. Willan, W Shelley, A. J. Bodurtha, T A McPherson, Alexander H.G. Paterson
Publikováno v:
Journal of Clinical Oncology. 9:729-735
Five hundred forty-three patients with completely resected malignant melanoma who were considered to have a significant risk of developing recurrent disease were randomized to one of four study groups. One group received levamisole 2.5 mg/kg on 2 con