Zobrazeno 1 - 10
of 14
pro vyhledávání: '"P B, Rupert"'
Autor:
Jennifer N. Wacker, Joshua J. Woods, Peter B. Rupert, Appie Peterson, Marc Allaire, Wayne W. Lukens, Alyssa N. Gaiser, Stefan G. Minasian, Roland K. Strong, Rebecca J. Abergel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Targeted alpha therapy (TAT) pairs the specificity of antigen targeting with the lethality of alpha particles to eradicate cancerous cells. Actinium-225 [225Ac; t1/2 = 9.920(3) days] is an alpha-emitting radioisotope driving the next generat
Externí odkaz:
https://doaj.org/article/b852e100a7e24175a5eaf16faeb613d7
Autor:
Peter B. Rupert, Matthew Buerger, Emily J. Girard, Marie Frutoso, Don Parrilla, Kevin Ng, Theodore Gooley, Veronika Groh, Roland K. Strong
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e28583- (2024)
NKG2D and its ligands are critical regulators of protective immune responses controlling infections and cancer, defining a crucial immune signaling axis. Current therapeutic efforts targeting this axis almost exclusively aim at enhancing NKG2D-mediat
Externí odkaz:
https://doaj.org/article/ff64ffa78a71418689ec662a6f844c00
Autor:
Ida Lin, Peter B. Rupert, Kristina Pilat, Raymond O. Ruff, Della J. Friend, Man Kid Chan, Midori Clarke, Benjamin G. Hoffstrom, Jane Carter, Soheil Meshinchi, Ashok D. Bandaranayake, Christopher Mehlin, James M. Olson, Roland K. Strong, Colin E. Correnti
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Mesothelin is a glypiated, cell-surface glycoprotein expressed at low levels on normal mesothelium but overexpressed by many cancers. Implicated in cell adhesion and multiple signaling pathways, mesothelin’s precise biological function and overall
Externí odkaz:
https://doaj.org/article/4119894bb87a422e91bef3d667f1bb92
Autor:
Kathryn A. K. Finton, Peter B. Rupert, Della J. Friend, Ana Dinca, Erica S. Lovelace, Matthew Buerger, Domnita V. Rusnac, Ulysses Foote-McNabb, William Chour, James R. Heath, Jean S. Campbell, Robert H. Pierce, Roland K. Strong
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
MHC class I “single-chain trimer” molecules, coupling MHC heavy chain, β2-microglobulin, and a specific peptide into a single polypeptide chain, are widely used in research. To more fully understand caveats associated with this design that may a
Externí odkaz:
https://doaj.org/article/738bbd7365bf4134a8132bf3cd7b009a
Autor:
Christopher B. Rupert, Laura N. Rusche
Publikováno v:
mSphere, Vol 7, Iss 3 (2022)
ABSTRACT Candida parapsilosis is an emerging fungal pathogen that primarily affects immunocompromised patients in hospitals. A significant risk factor is the use of implanted medical devices, which support the growth of biofilms composed of a mixture
Externí odkaz:
https://doaj.org/article/a1eaa57a0c194f00926ec06e336060db
Autor:
Matthew C. Clifton, Peter B. Rupert, Trisha M. Hoette, Kenneth N. Raymond, Rebecca J. Abergel, Roland K. Strong
Publikováno v:
Journal of Structural Biology: X, Vol 2, Iss , Pp - (2019)
Siderocalin/Lipocalin 2/Neutrophil Gelatinase Associated Lipocalin/24p3 is an innate immune system protein with bacteriostatic activity, acting by tightly binding and sequestering diverse catecholate and mixed-type ferric siderophores from enteric ba
Externí odkaz:
https://doaj.org/article/19f4706a2fbd4910b68af3fc9a07266d
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 10, Pp 3297-3305 (2016)
Gene duplication promotes the diversification of protein functions in several ways. Ancestral functions can be partitioned between the paralogs, or a new function can arise in one paralog. These processes are generally viewed as unidirectional. Howev
Externí odkaz:
https://doaj.org/article/5b6e1c5bf530401d940f4efb444676be
Autor:
Jonathan Barasch, Maria Hollmen, Rong Deng, Eldad A. Hod, Peter B. Rupert, Rebecca J. Abergel, Benjamin E. Allred, Katherine Xu, Shaun F. Darrah, Yared Tekabe, Alan Perlstein, Rebecca Wax, Efrat Bruck, Jacob Stauber, Kaitlyn A. Corbin, Charles Buchen, Vesna Slavkovich, Joseph Graziano, Steven L. Spitalnik, Guanhu Bao, Roland K. Strong, Andong Qiu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Iron overload can be either hereditary or acquired via transfusions, and current treatments include the use of iron chelators that have adverse effects in some patients. Here the authors modify siderocalin to enhance iron excretion in urine, and demo
Externí odkaz:
https://doaj.org/article/3ae332e27072492dad5e0ff733401a56
Autor:
Kathryn A K Finton, Kevin Larimore, H Benjamin Larman, Della Friend, Colin Correnti, Peter B Rupert, Stephen J Elledge, Philip D Greenberg, Roland K Strong
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003639 (2013)
The broadly-neutralizing anti-HIV antibody 4E10 recognizes an epitope in the membrane-proximal external region of the HIV envelope protein gp41. Previous attempts to elicit 4E10 by vaccination with envelope-derived or reverse-engineered immunogens ha
Externí odkaz:
https://doaj.org/article/fbe83d0bea4944d3b9658816999ae3c3
Autor:
Frederick W. Dahlquist, P B Rupert, P J Domaille, F J Moy, A F Roth, David F. Lowry, P Matsumura
Publikováno v:
Journal of Biological Chemistry. 269:26358-26362
The CheY protein from Escherichia coli and Salmonella typhimurium are among the best characterized proteins of the receiver domain family of two component signal transduction systems in bacteria. Phosphorylation of CheY plays a central role in bacter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::159160e5ac7b9616e6adae0a016227a8
https://doi.org/10.1016/s0021-9258(18)47201-8
https://doi.org/10.1016/s0021-9258(18)47201-8