Zobrazeno 1 - 10
of 10
pro vyhledávání: '"P B, Krastev"'
Autor:
Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 369-385 (2024)
The F‐box and WD repeat domain containing 7 (FBXW7) tumour suppressor gene encodes a substrate‐recognition subunit of Skp, cullin, F‐box (SCF)‐containing complexes. The tumour‐suppressive role of FBXW7 is ascribed to its ability to drive ub
Externí odkaz:
https://doaj.org/article/394126b61bef4541813ab49cbc06b55c
Autor:
Anabel Zelceski, Paola Francica, Lea Lingg, Merve Mutlu, Colin Stok, Martin Liptay, John Alexander, Joseph S. Baxter, Rachel Brough, Aditi Gulati, Syed Haider, Maya Raghunandan, Feifei Song, Sandhya Sridhar, Josep V. Forment, Mark J. O’Connor, Barry R. Davies, Marcel A.T.M. van Vugt, Dragomir B. Krastev, Stephen J. Pettitt, Andrew N.J. Tutt, Sven Rottenberg, Christopher J. Lord
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112484- (2023)
Summary: The PSMC3IP-MND1 heterodimer promotes meiotic D loop formation before DNA strand exchange. In genome-scale CRISPR-Cas9 mutagenesis and interference screens in mitotic cells, depletion of PSMC3IP or MND1 causes sensitivity to poly (ADP-Ribose
Externí odkaz:
https://doaj.org/article/9820d80912b4460eb12878b12cea41b1
Autor:
Ilirjana Bajrami, Callum Walker, Dragomir B. Krastev, Daniel Weekes, Feifei Song, Andrew J. Wicks, John Alexander, Syed Haider, Rachel Brough, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Bajrami, Walker et al. investigated the synthetic lethality between BRCA gene defects and inhibition of two sirtuin genes, SIRT1 or SIRT6, which was found to be associated with replication stress and increased PARylation. The authors demonstrated tha
Externí odkaz:
https://doaj.org/article/d5f5e8c9681d4c1cb2934f06ed9a1386
Autor:
Andrew J. Wicks, Dragomir B. Krastev, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Publikováno v:
Open Biology, Vol 12, Iss 7 (2022)
PARP inhibitors (PARPi) have been demonstrated to exhibit profound anti-tumour activity in individuals whose cancers have a defect in the homologous recombination DNA repair pathway. Here, we describe the current consensus as to how PARPi work and ho
Externí odkaz:
https://doaj.org/article/4b60bfc0f8324ff39565168634c77471
Autor:
Juliana Schell, Dmitry Zyabkin, Krish Bharuth-Ram, João N. Gonçalves, Carlos Díaz-Guerra, Haraldur P. Gunnlaugsson, Aitana Tarazaga Martín-Luengo, Peter Schaaf, Alberta Bonanni, Hilary Masenda, Thien Thanh Dang, Torben E. Mølholt, Sveinn Ólafsson, Iraultza Unzueta, Roberto Mantovan, Karl Johnston, Hafliði P. Gíslason, Petko B. Krastev, Deena Naidoo, Bingcui Qi
Publikováno v:
Crystals, Vol 12, Iss 7, p 942 (2022)
Van der Waals α-MoO3 samples offer a wide range of attractive catalytic, electronic, and optical properties. We present herein an emission Mössbauer spectroscopy (eMS) study of the electric-field gradient (EFG) anisotropy in crystalline free-standi
Externí odkaz:
https://doaj.org/article/df04a760a38943e5bf402682fc167b61
Autor:
Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Radoslav Aleksandrov, Maria I. Harrell, Malini Menon, Rachel Brough, James Campbell, Jessica Frankum, Michael Ranes, Helen N. Pemberton, Rumana Rafiq, Kerry Fenwick, Amanda Swain, Sebastian Guettler, Jung-Min Lee, Elizabeth M. Swisher, Stoyno Stoynov, Kosuke Yusa, Alan Ashworth, Christopher J. Lord
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The mechanisms of PARP inhibitor (PARPi) resistance are poorly understood. Here the authors employ a CRISPR mutagenesis approach to identify PARP1 mutants causing PARPi resistance and find that PARP1 mutations are tolerated in BRCA1 mutated cells, su
Externí odkaz:
https://doaj.org/article/1eb977c74fb546b0a7321e49be5d0643
Autor:
Dragomir B. Krastev, Stephen J. Pettitt, James Campbell, Feifei Song, Barbara E. Tanos, Stoyno S. Stoynov, Alan Ashworth, Christopher J. Lord
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Poly ADP-ribosylation (PARylation) is a highly dynamic post-translation protein modification, but most methods only detect stable PARylation events. Here the authors develop a split-GFP-based sensor for PARylation detection in live cells and use it t
Externí odkaz:
https://doaj.org/article/6b4485c994204db1bfb5e33371cc705b
Autor:
Mikołaj Słabicki, Mirko Theis, Dragomir B Krastev, Sergey Samsonov, Emeline Mundwiller, Magno Junqueira, Maciej Paszkowski-Rogacz, Joan Teyra, Anne-Kristin Heninger, Ina Poser, Fabienne Prieur, Jérémy Truchetto, Christian Confavreux, Cécilia Marelli, Alexandra Durr, Jean Philippe Camdessanche, Alexis Brice, Andrej Shevchenko, M Teresa Pisabarro, Giovanni Stevanin, Frank Buchholz
Publikováno v:
PLoS Biology, Vol 8, Iss 6, p e1000408 (2010)
DNA repair is essential to maintain genome integrity, and genes with roles in DNA repair are frequently mutated in a variety of human diseases. Repair via homologous recombination typically restores the original DNA sequence without introducing mutat
Externí odkaz:
https://doaj.org/article/f5f2a05ab4b94ace913261bc60a1e2dd
Autor:
Rayna I Kraeva, Dragomir B Krastev, Assen Roguev, Anna Ivanova, Marina N Nedelcheva-Veleva, Stoyno S Stoynov
Publikováno v:
PLoS ONE, Vol 2, Iss 3, p e290 (2007)
Nucleic acids, due to their structural and chemical properties, can form double-stranded secondary structures that assist the transfer of genetic information and can modulate gene expression. However, the nucleotide sequence alone is insufficient in
Externí odkaz:
https://doaj.org/article/9f70667919944615872ee52e95a85edd
Autor:
P B, Krastev, H P, Gunnlaugsson, K, Nomura, K, Bharuth-Ram, B, Qi, H, Masenda, T E, Mølholt, D, Naidoo, S, Ólafsson, A Tarazaga, Martín-Luengo, I, Unzueta, K, Johnston, J, Schell, H P, Gislason
Publikováno v:
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 160
The change in the Curie temperature of single crystalline garnet Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f205cde447c5040bf2a242029d0bbc9
https://pubmed.ncbi.nlm.nih.gov/32174465
https://pubmed.ncbi.nlm.nih.gov/32174465