Zobrazeno 1 - 10
of 101
pro vyhledávání: '"P B, Hylemon"'
Autor:
Yanyan Wang, Derrick Zhao, Lianyong Su, Yun-Ling Tai, Grayson W. Way, Jing Zeng, Qianhua Yan, Ying Xu, Xuan Wang, Emily C. Gurley, Xi-Qiao Zhou, Jinze Liu, Jinpeng Liu, Weidong Chen, Phillip B. Hylemon, Huiping Zhou
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Background and aims Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by progressive biliary inflammation and bile duct injury. Berberine (BBR) is a bioactive isoquinoline alkaloid found in various herbs and has m
Externí odkaz:
https://doaj.org/article/c40cee7852b64c49988c83b99ea9710b
Autor:
Jennifer T. Wolstenholme, Justin M. Saunders, Maren Smith, Jason D. Kang, Phillip B. Hylemon, Javier González-Maeso, Andrew Fagan, Derrick Zhao, Masoumeh Sikaroodi, Jeremy Herzog, Amirhossein Shamsaddini, Marcela Peña-Rodríguez, Lianyong Su, Yun-Ling Tai, Jing Zheng, Po-Cheng Cheng, R. Balfour Sartor, Patrick M. Gillevet, Huiping Zhou, Jasmohan S. Bajaj
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Gut microbiota composition is altered in patients with alcohol use disorder, and fecal microbiota transplant reduced alcohol craving in patients with alcohol use disorder and liver cirrhosis in a phase 1 clinical trial. Here the authors used stool sa
Externí odkaz:
https://doaj.org/article/71cd530afe02445e92a5c780310d4264
Autor:
Yanyan Wang, Yun-Ling Tai, Grayson Way, Jing Zeng, Derrick Zhao, Lianyong Su, Xixian Jiang, Kaitlyn G. Jackson, Xuan Wang, Emily C. Gurley, Jinze Liu, Jinpeng Liu, Weidong Chen, Xiang-Yang Wang, Arun J. Sanyal, Phillip B. Hylemon, Huiping Zhou
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Background NAFLD has become the most common chronic liver disease worldwide. Human antigen R (HuR), an RNA-binding protein, is an important post-transcriptional regulator. HuR has been reported as a key player in regulating lipid homeostasis
Externí odkaz:
https://doaj.org/article/d84759287cdb4599b7709d2778b2a56b
Autor:
Genta Kakiyama, Dalila Marques, Rebecca Martin, Hajime Takei, Daniel Rodriguez-Agudo, Sandra A. LaSalle, Taishi Hashiguchi, Xiaoying Liu, Richard Green, Sandra Erickson, Gregorio Gil, Michael Fuchs, Mitsuyoshi Suzuki, Tsuyoshi Murai, Hiroshi Nittono, Phillip B. Hylemon, Huiping Zhou, William M. Pandak
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1629-1644 (2020)
NAFLD is an important public health issue closely associated with the pervasive epidemics of diabetes and obesity. Yet, despite NAFLD being among the most common of chronic liver diseases, the biological factors responsible for its transition from be
Externí odkaz:
https://doaj.org/article/f22dc345203d48c1bae1f66f709fdca2
Publikováno v:
Cells, Vol 12, Iss 5, p 792 (2023)
Biliary fibrosis is the driving pathological process in cholangiopathies such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Cholangiopathies are also associated with cholestasis, which is the retention of biliary comp
Externí odkaz:
https://doaj.org/article/a0b7f108441c41eaa437150539ce9833
Publikováno v:
Non-Coding RNA, Vol 9, Iss 2, p 19 (2023)
Liver cancer is the second leading cause of cancer-related death globally, with limited treatment options. Recent studies have demonstrated the critical role of long noncoding RNAs (lncRNAs) in the pathogenesis of liver cancers. Of note, mounting evi
Externí odkaz:
https://doaj.org/article/3e448548770340cea810f34d9faf9250
Autor:
Yuan Zhang, Jason D. Kang, Derrick Zhao, Siddartha S. Ghosh, Yanyan Wang, Yunling Tai, Javier Gonzalez-Maeso, Masoumeh Sikaroodi, Patrick M. Gillevet, H. Robert Lippman, Phillip B. Hylemon, Huiping Zhou, Jasmohan S. Bajaj
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
BackgroundCirrhosis and hepatic encephalopathy (HE) are linked with an altered gut-liver-brain axis, however, the relative contribution of hepatic vagal innervation is unclear. We aimed to determine the impact of hepatic vagotomy on the gut microbiom
Externí odkaz:
https://doaj.org/article/88a0eab8c12b4e55977c23ab76ba90da
Autor:
Yaping Wang, Weiqi Lin, James E. Brown, Lanming Chen, Williams M. Pandak, Phillip B. Hylemon, Shunlin Ren
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100063- (2021)
The oxysterol sulfate, 25-hydroxycholesterol 3-sulfate (25HC3S), has been shown to play an important role in lipid metabolism, inflammatory response, and cell survival. However, the mechanism(s) of its function in global regulation is unknown. The cu
Externí odkaz:
https://doaj.org/article/23a8f570dd7e483cbf355e7dc243b0b6
Autor:
Yaping Wang, Lanming Chen, William M. Pandak, Douglas Heuman, Phillip B. Hylemon, Shunlin Ren
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: This work investigates the relationship between high-glucose (HG) culture, CpG methylation of genes involved in cell signaling pathways, and the regulation of carbohydrate and lipid metabolism in hepatocytes. The results indicate that HG lea
Externí odkaz:
https://doaj.org/article/c39ef8d21e814819baf9eef3ec805633
Autor:
Yanyan Wang, Xiqiao Zhou, Derrick Zhao, Xuan Wang, Emily C Gurley, Runping Liu, Xiaojiaoyang Li, Phillip B Hylemon, Weidong Chen, Huiping Zhou
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232630 (2020)
Inflammation plays an essential role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Berberine (BBR), an isoquinoline alkaloid isolated from Chinese medicinal herbs, has been widely used to treat various diseases, including liver di
Externí odkaz:
https://doaj.org/article/79e26f179ae04c5c936faf410f948ef3