Zobrazeno 1 - 10
of 89
pro vyhledávání: '"P B, Farmer"'
Autor:
S. N. Fox, L. J. McMeekin, C. H. Savage, K. L. Joyce, S. M. Boas, M. S. Simmons, C. B. Farmer, J. Ryan, L. Pereboeva, K. Becker, J. Auwerx, S. Sudarshan, J. Ma, A. Lee, R. C. Roberts, D. K. Crossman, A. Kralli, R. M. Cowell
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-19 (2022)
Abstract Many studies implicate mitochondrial dysfunction as a key contributor to cell loss in Parkinson disease (PD). Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded
Externí odkaz:
https://doaj.org/article/ea2bd0f17cd2417ea87f86dbe8b0be2d
Autor:
Rose B. Creed, Rosalinda C. Roberts, Charlene B. Farmer, Lori L. McMahon, Matthew S. Goldberg
Publikováno v:
Neurobiology of Disease, Vol 150, Iss , Pp 105246- (2021)
Loss-of-function PTEN Induced Kinase 1 (PINK1) mutations cause early-onset familial Parkinson's disease (PD) with similar clinical and neuropathological characteristics as idiopathic PD. While Pink1 knockout (KO) rats have mitochondrial dysfunction,
Externí odkaz:
https://doaj.org/article/4453aa85f5e347e6a224e273653d972f
Autor:
Michael Engel, Damon B. Farmer, Jaione Tirapu Azpiroz, Jung-Woo T. Seo, Joohoon Kang, Phaedon Avouris, Mark C. Hersam, Ralph Krupke, Mathias Steiner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
The placement of nanomaterials at predefined locations is a key requirement for their integration in nanoelectronic devices. Here, the authors devise a method allowing placement of solution-based nanomaterials by using structured graphene layers as d
Externí odkaz:
https://doaj.org/article/cb5a4df863e04d9d9191cfdf2e582df5
Publikováno v:
AIP Advances, Vol 8, Iss 5, Pp 055708-055708-7 (2018)
Single-crystal x-ray diffraction refinements indicate SrSn2Fe4O11 crystallizes in the hexagonal R-type ferrite structure with non-centrosymmetric space group P63mc and lattice parameters a = 5.9541(2) Å, c = 13.5761(5) Å, Z = 2 (R(F) = 0.034). Octa
Externí odkaz:
https://doaj.org/article/bfdb8a63eaa643459fa1c94cf8607ffd
Autor:
Wei Jie Seow, Angela Cecilia Pesatori, Emmanuel Dimont, Peter B Farmer, Benedetta Albetti, Adrienne S Ettinger, Valentina Bollati, Claudia Bolognesi, Paola Roggieri, Teodor I Panev, Tzveta Georgieva, Domenico Franco Merlo, Pier Alberto Bertazzi, Andrea A Baccarelli
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50471 (2012)
Chronic occupational exposure to benzene is associated with an increased risk of hematological malignancies such as acute myeloid leukemia (AML), but the underlying mechanisms are still unclear. The main objective of this study was to investigate the
Externí odkaz:
https://doaj.org/article/81ca54f56ee2425da568eb6a120d17c6
Autor:
Valentina Gallo, Matthias Egger, Valerie McCormack, Peter B Farmer, John P A Ioannidis, Micheline Kirsch-Volders, Giuseppe Matullo, David H Phillips, Bernadette Schoket, Ulf Stromberg, Roel Vermeulen, Christopher Wild, Miquel Porta, Paolo Vineis, STROBE Statement
Publikováno v:
PLoS Medicine, Vol 8, Iss 10, p e1001117 (2011)
Externí odkaz:
https://doaj.org/article/90ea98b7304f471c879937baaae572c0
Autor:
Ann-Karin Olsen, Ashild Andreassen, Rajinder Singh, Richard Wiger, Nur Duale, Peter B Farmer, Gunnar Brunborg
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11349 (2010)
BACKGROUND: Spermatozoal DNA damage is associated with poor sperm quality, disturbed embryonic development and early embryonic loss, and some genetic diseases originate from paternal de novo mutations. We previously reported poor repair of bulky DNA-
Externí odkaz:
https://doaj.org/article/fd20ad52553d49ff9f70a3387410d4f4
Autor:
Margaret Gaskell, Colin J. Henderson, Chee-Onn Leong, R. Wolf, Tracey D. Bradshaw, Mary Bruce, P. B. Farmer, Malcolm F. G. Stevens, J.E. Wren, David A. Barrett, E.K. Wright
Publikováno v:
Pharmacology. 83:99-109
Background and Aims: The 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole prodrug Phortress exerts potent and selective antitumour activity in vitro and in vivo. Preclinical toxicokinetic studies in 2 rodent species were undertaken to determine Phort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93178d05173c8a1408e721001455a4e
https://doi.org/10.1159/000183846
https://doi.org/10.1159/000183846
Autor:
P. B. Farmer, G. M. A. Sweetman
Publikováno v:
Journal of Mass Spectrometry. 30:1369-1379
Genotoxic carcinogens interact with nucleic acids and proteins to yield covalently bound products (adducts), the quantitative determination of which has been proposed as a biomonitor of human exposure to carcinogens. Mass spectrometry is playing a le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f96d97b85b0be24e01c920ac82f431c
https://doi.org/10.1002/jms.1190301002
https://doi.org/10.1002/jms.1190301002
Autor:
P B Farmer
Publikováno v:
Clinical Chemistry. 40:1438-1443
Exposure to genotoxic carcinogens results in the formation of covalently bound adducts of the carcinogens with cellular nucleophilic molecules, including DNA and protein. Quantitative measurements of these adducts may be used to monitor exposure to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e62c26676cbd48970cb0e98d20ca4737
https://doi.org/10.1093/clinchem/40.7.1438
https://doi.org/10.1093/clinchem/40.7.1438