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Autor: Sa-Ouk Kang, Moon B. Yim, Cheolju Lee, P B Chock, H S Yim

Publikováno v: Annals of the New York Academy of Sciences. 928:48-53

In a glycation reaction, alpha-dicarbonyl compounds such as deoxyglucosone, methylglyoxal, and glyoxal are more reactive than the parent sugars with respect to their ability to react with amino groups of proteins to form inter- and intramolecular cro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62edf89dfc503017cd5c73884bd2b2b7
https://doi.org/10.1111/j.1749-6632.2001.tb05634.x

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Regulation of oxidative stress-induced calcium release by phosphatidylinositol 3-kinase and Bruton's tyrosine kinase in B cells

Autor: E R Stadtman, S Qin, P B Chock

Publikováno v: Proceedings of the National Academy of Sciences. 97:7118-7123

Hydrogen peroxide stimulates a tyrosine kinase-dependent calcium release from intracellular stores, which is assumed to be achieved through the activation of phospholipase Cγ2 (PLCγ2) via a tyrosine phosphorylation mechanism in B cells. Here we sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e54c20219250d6824284b0eafa63ed
https://doi.org/10.1073/pnas.130198197

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Regulation of PTP1B via Glutathionylation of the Active Site Cysteine 215

Autor: H M Fales, Simone König, William C. Barrett, Yen Fang Keng, M B Yim, P B Chock, Zhong Yin Zhang, J P DeGnore

Publikováno v: Biochemistry. 38:6699-6705

The reversible regulation of protein tyrosine phosphatase is an important mechanism in processing signal transduction and regulating cell cycle. Recent reports have shown that the active site cysteine residue, Cys215, can be reversibly oxidized to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff4143b879b4babd6f20c492f8c7638
https://doi.org/10.1021/bi990240v

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Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

Autor: Yun Soo Bae, Sue Goo Rhee, P B Chock, Ivan C. Baines, Ephrem Tekle, Sang Won Kang, Minseok Seo

Publikováno v: Journal of Biological Chemistry. 272:217-221

Recent evidence indicates that reactive oxygen species (ROS) may function as intracellular messengers in receptor signaling pathways. The possible role of ROS in epidermal growth factor (EGF) signaling was therefore investigated. Stimulation of A431

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89badd2cc4e9a90ce49559a4e4c9c5f1
https://doi.org/10.1074/jbc.272.1.217

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Peroxynitrite-mediated nitration of tyrosine residues in Escherichia coli glutamine synthetase mimics adenylylation: relevance to signal transduction

Autor: Earl R. Stadtman, Bertrand Friguet, P B Chock, M B Yim, Barbara S. Berlett

Publikováno v: Proceedings of the National Academy of Sciences. 93:1776-1780

Treatment of Escherichia coli glutamine synthetase (GS) with peroxynitrite leads to nitration of some tyrosine residues and conversion of some methionine residues to methionine sulfoxide (MSOX) residues. Nitration, but not MSOX formation, is stimulat

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https://doi.org/10.1073/pnas.93.5.1776

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Phosphorylation of ubiquitin-activating enzyme in cultured cells

Autor: J C Cook, P B Chock

Publikováno v: Proceedings of the National Academy of Sciences. 92:3454-3457

Ubiquitin-activating enzyme, E1, is the first enzyme in the pathway leading to formation of ubiquitin-protein conjugates. E1 exists as two isoforms in human cells which are separable by electrophoresis. These isoforms migrate with apparent molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461038db4b552da1a0d3a6f7c42b35d5
https://doi.org/10.1073/pnas.92.8.3454

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Selective and asymmetric molecular transport across electroporated cell membranes

Autor: R D Astumian, Ephrem Tekle, P B Chock

Publikováno v: Proceedings of the National Academy of Sciences. 91:11512-11516

Transport of a divalent cation (Ca2+) and three DNA indicators [ethidium bromide (EB), propidium iodide (PI), and ethidium homodimer (EthD-1)] across electroporated membranes of several mammalian cell lines was found to be selective and asymmetrical.

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https://doi.org/10.1073/pnas.91.24.11512

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Enzyme function of copper, zinc superoxide dismutase as a free radical generator

Autor: Moon B. Yim, P B Chock, Earl R. Stadtman

Publikováno v: Journal of Biological Chemistry. 268:4099-4105

The peroxidative activity of Cu,Zn-containing superoxide dismutase (Cu, Zn-SOD) was studied by using a chromogen, 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS) which reacts with .OH radicals to form ABTS+, and the spin traps, N-tert-butyl-

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https://doi.org/10.1016/s0021-9258(18)53585-7

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