Zobrazeno 1 - 10
of 19
pro vyhledávání: '"P Adolfo Sequeira"'
Autor:
Audrey A. Omidsalar, Carmel G. McCullough, Lili Xu, Stanley Boedijono, Daniel Gerke, Michelle G. Webb, Zarko Manojlovic, Adolfo Sequeira, Mark F. Lew, Marco Santorelli, Geidy E. Serrano, Thomas G. Beach, Agenor Limon, Marquis P. Vawter, Brooke E. Hjelm
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-20 (2024)
Abstract Common mitochondrial DNA (mtDNA) deletions are large structural variants in the mitochondrial genome that accumulate in metabolically active tissues with age and have been investigated in various diseases. We applied the Splice-Break2 pipeli
Externí odkaz:
https://doaj.org/article/b606b4bfef3147a49f38ed1db08b12ca
Autor:
Brandi Rollins, Maureen V Martin, P Adolfo Sequeira, Emily A Moon, Ling Z Morgan, Stanley J Watson, Alan Schatzberg, Huda Akil, Richard M Myers, Edward G Jones, Douglas C Wallace, William E Bunney, Marquis P Vawter
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4913 (2009)
Mitochondria provide most of the energy for brain cells by the process of oxidative phosphorylation. Mitochondrial abnormalities and deficiencies in oxidative phosphorylation have been reported in individuals with schizophrenia (SZ), bipolar disorder
Externí odkaz:
https://doaj.org/article/523d2221d27b4bebab8b9f1054afd083
Autor:
Kathleen T. Watson, Jennifer Keller, Caleb M. Spiro, Isaac B. Satz, Samantha V. Goncalves, Heather Pankow, Idit Kosti, Benoit Lehallier, Adolfo Sequeira, William E. Bunney, Natalie L. Rasgon, Alan F. Schatzberg
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 36, Iss , Pp 100731- (2024)
Objective: This study assessed the proteomic profiles of cytokines and chemokines in individuals with moderate to severe depression, with or without comorbid medical disorders, compared to healthy controls. Two proteomic multiplex platforms were empl
Externí odkaz:
https://doaj.org/article/c3864dafc4b34475941dd04b6d222190
Autor:
Adriana M. Medina, Megan Hastings Hagenauer, David M. Krolewski, Evan Hughes, Liam Cannon Thew Forrester, David M. Walsh, Maria Waselus, Evelyn Richardson, Cortney A. Turner, P. Adolfo Sequeira, Preston M. Cartagena, Robert C. Thompson, Marquis P. Vawter, Blynn G. Bunney, Richard M. Myers, Jack D. Barchas, Francis S. Lee, Alan F. Schatzberg, William E. Bunney, Huda Akil, Stanley J. Watson
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The frontal pole (Brodmann area 10, BA10) is the largest cytoarchitectonic region of the human cortex, performing complex integrative functions. BA10 undergoes intensive adolescent grey matter pruning prior to the age of onset for bipolar di
Externí odkaz:
https://doaj.org/article/ecdaa6095ceb4f37b0d1e6facf90baf0
Autor:
Sujan C. Das, Brooke E. Hjelm, Brandi L. Rollins, Adolfo Sequeira, Ling Morgan, Audrey A. Omidsalar, Alan F. Schatzberg, Jack D. Barchas, Francis S. Lee, Richard M. Myers, Stanley J. Watson, Huda Akil, William E. Bunney, Marquis P. Vawter
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Mitochondrial dysfunction is a neurobiological phenomenon implicated in the pathophysiology of schizophrenia and bipolar disorder that can synergistically affect synaptic neurotransmission. We hypothesized that schizophrenia and bipolar diso
Externí odkaz:
https://doaj.org/article/6f2dcb64f3264a568f9d012a75e13127
Autor:
Firoza Mamdani, Matthieu D. Weber, Blynn Bunney, Kathleen Burke, Preston Cartagena, David Walsh, Francis S. Lee, Jack Barchas, Alan F. Schatzberg, Richard M. Myers, Stanley J. Watson, Huda Akil, Marquis P. Vawter, William E. Bunney, Adolfo Sequeira
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Suicides have increased to over 48,000 deaths yearly in the United States. Major depressive disorder (MDD) is the most common diagnosis among suicides, and identifying those at the highest risk for suicide is a pressing challenge. The object
Externí odkaz:
https://doaj.org/article/14687cc533e84d7586bd3f5377770ca1
Autor:
Adriana M. Medina, Megan Hastings Hagenauer, David M. Krolewski, Evan Hughes, Liam Cannon Thew Forrester, David M. Walsh, Maria Waselus, Evelyn Richardson, Cortney A. Turner, P. Adolfo Sequeira, Preston M. Cartagena, Robert C. Thompson, Marquis P. Vawter, Blynn G. Bunney, Richard M. Myers, Jack D. Barchas, Francis S.Y. Lee, Alan F. Schatzberg, William E. Bunney, Huda Akil, Stanley J. Watson
Brodmann Area 10 (BA10) is the largest cytoarchitectonic region of the human cortex, performing complex integrative functions. BA10 undergoes intensive adolescent grey matter pruning around the average age of onset for Bipolar disorder (BP) and Schiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acc3f653834b9d7a12bbcd83ceb0f7a6
https://doi.org/10.1101/2022.06.03.22275600
https://doi.org/10.1101/2022.06.03.22275600
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 1, Pp 23-36 (2012)
Gene expression changes in brains of individuals with schizophrenia (SZ) have been hypothesized to reflect possible pathways related to pathophysiology and/or medication. Other factors having robust effects on gene expression profiling in brain and p
Externí odkaz:
https://doaj.org/article/7d9f76e658984fd788c3fcaa7360b809
Autor:
Adolfo Sequeira, Ling Morgan, David M Walsh, Preston M Cartagena, Prabhakara Choudary, Jun Li, Alan F Schatzberg, Stanley J Watson, Huda Akil, Richard M Myers, Edward G Jones, William E Bunney, Marquis P Vawter
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35367 (2012)
Suicidal behaviors are frequent in mood disorders patients but only a subset of them ever complete suicide. Understanding predisposing factors for suicidal behaviors in high risk populations is of major importance for the prevention and treatment of
Externí odkaz:
https://doaj.org/article/e29bd6914dd94ab4b20cd9bc7398ed88
Autor:
Tommaso Zeppillo, William E. Bunney, Melanie Föcking, David Cotter, Agenor Limon, Anton Schulmann, Brooke E. Hjelm, Ilaria Guella, P. Adolfo Sequeira, Marquis P. Vawter, Fabio Macciardi
Publikováno v:
Schizophr Res
Clinical and preclinical studies suggest that some of the behavioral alterations observed in schizophrenia (SZ) may be mechanistically linked to synaptic dysfunction of glutamatergic signaling. Recent genetic and proteomic studies suggest alterations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf300a659e00103523c9b35c6fbe413
https://pubmed.ncbi.nlm.nih.gov/32513544
https://pubmed.ncbi.nlm.nih.gov/32513544