Zobrazeno 1 - 10
of 1 131
pro vyhledávání: '"P A Sleigh"'
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111158- (2024)
Summary: Efficient long-range axonal transport is essential for maintaining neuronal function, and perturbations in this process underlie severe neurological diseases. Nodes of Ranvier (NoR) are short, specialized unmyelinated axonal domains with a u
Externí odkaz:
https://doaj.org/article/1528170810e44ac7b7cf79d7b3ada18a
Autor:
Elena R. Rhymes, Rebecca L. Simkin, Ji Qu, David Villarroel-Campos, Sunaina Surana, Yao Tong, Ryan Shapiro, Robert W. Burgess, Xiang-Lei Yang, Giampietro Schiavo, James N. Sleigh
Publikováno v:
Neurobiology of Disease, Vol 195, Iss , Pp 106501- (2024)
Charcot-Marie-Tooth disease (CMT) is a genetic peripheral neuropathy caused by mutations in many functionally diverse genes. The aminoacyl-tRNA synthetase (ARS) enzymes, which transfer amino acids to partner tRNAs for protein synthesis, represent the
Externí odkaz:
https://doaj.org/article/6a2c5beddc18443097b6a65f58d65c80
We describe a variational framework for non-commuting flows, extending the theories of Lagrangian multiforms and pluri-Lagrangian systems, which have gained prominence in recent years as a variational description of integrable systems in the sense of
Externí odkaz:
http://arxiv.org/abs/2204.09663
Publikováno v:
Humanities & Social Sciences Communications, Vol 11, Iss 1, Pp 1-10 (2024)
Abstract In the age of Machine Learning Algorithms, Artificial Intelligence and Natural Language Processing, digital technologies have become interwoven in various aspects of society, including in our practices for ethical deliberation and decision-m
Externí odkaz:
https://doaj.org/article/a4a1c5d00101482696eaf548f4790a7f
We define a conformally invariant action S on gauge connections on a closed pseudo-Riemannian manifold M of dimension 6. At leading order this is quadratic in the gauge connection. The Euler-Lagrange equations of S, with respect to variation of the g
Externí odkaz:
http://arxiv.org/abs/2107.08515
Publikováno v:
Journal of the American Medical Informatics Association ocab096 (2021)
Our scoping review aims to assess what legal, ethical, and socio-technical factors contribute or inhibit the success of national eHealth system implementations. In addition, our review seeks to describe the characteristics and benefits of eHealth sys
Externí odkaz:
http://arxiv.org/abs/2106.08737
Data collection and processing via digital public health technologies are being promoted worldwide by governments and private companies as strategic remedies for mitigating the COVID-19 pandemic and loosening lockdown measures. However, the ethical a
Externí odkaz:
http://arxiv.org/abs/2004.10236
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 8, Pp 1653-1654 (2024)
Externí odkaz:
https://doaj.org/article/ed5f9861e96f4337bdd89b0c22b5c40d
Publikováno v:
International Journal of Public Health, Vol 68 (2023)
Objectives: To investigate associations between multimorbidity, socio-demographic and health behaviour factors, and their interactions (multimorbidity and these factors) with all-cause mortality among Thai adults.Methods: Associations between multimo
Externí odkaz:
https://doaj.org/article/3549f67cbcfe4cb8aa76456a46d6bc30
Autor:
Amanda Pocratsky, James Sleigh
Publikováno v:
Bio-Protocol, Vol 13, Iss 18 (2023)
Administration of substances into neonatal mice is required for early treatment with pre-clinical therapeutics, delivery of recombination-inducing substances, and dosing with viruses or toxins, amongst other things. Several injection routes into mous
Externí odkaz:
https://doaj.org/article/f0b6a0db83f34311ab13868526d899ad