Zobrazeno 1 - 10
of 28
pro vyhledávání: '"P A M, de Witte"'
Autor:
Kalijn F. Bol, Gerty Schreibelt, Martine Bloemendal, Wouter W. van Willigen, Simone Hins-de Bree, Anna L. de Goede, Annemiek J. de Boer, Kevin J. H. Bos, Tjitske Duiveman-de Boer, Michel A. M. Olde Nordkamp, Tom G. M. van Oorschot, Carlijn J. Popelier, Jeanne M. Pots, Nicole M. Scharenborg, Mandy W. M. M. van de Rakt, Valeska de Ruiter, Wilmy S. van Meeteren, Michelle M. van Rossum, Sandra J. Croockewit, Bouke J. Koeneman, Jeroen H. A. Creemers, Inge M. N. Wortel, Caroline Angerer, Mareke Brüning, Katja Petry, Andrzej Dzionek, Astrid A. van der Veldt, Dirk J. van Grünhagen, Johanna E. M. Werner, Johannes J. Bonenkamp, John B. A. G. Haanen, Marye J. Boers-Sonderen, Rutger H. T. Koornstra, Martijn F. Boomsma, Erik H. J. Aarntzen, Martin Gotthardt, James Nagarajah, Theo J. M. de Witte, Carl G. Figdor, Johannes H. W. de Wilt, Johannes Textor, Jan Willem B. de Groot, Winald R. Gerritsen, I. Jolanda M. de Vries
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Autologous natural dendritic cells (nDCs) treatment can induce tumor-specific immune responses and clinical responses in cancer patients. In this phase III clinical trial (NCT02993315), 148 patients with resected stage IIIB/C melanoma were r
Externí odkaz:
https://doaj.org/article/245269452ff04a81b46a9a6846fb6516
Autor:
A. D. Meringa, P. Hernández-López, A. Cleven, M. de Witte, T. Straetemans, J. Kuball, D. X. Beringer, Z. Sebestyen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/adc4ef23bed647bca5b284ce5c416814
Modulation of sleep behavior in zebrafish larvae by pharmacological targeting of the orexin receptor
Autor:
Marie Pardon, Pieter Claes, Sarah Druwé, Murielle Martini, Aleksandra Siekierska, Christel Menet, Peter A. M. de Witte, Daniëlle Copmans
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
New pharmacological approaches that target orexin receptors (OXRs) are being developed to treat sleep disorders such as insomnia and narcolepsy, with fewer side effects than existing treatments. Orexins are neuropeptides that exert excitatory effects
Externí odkaz:
https://doaj.org/article/30dde744214246fa83c94fa1c4cdc927
Autor:
Ann-Sofie De Meulemeester, Lise Heylen, Aleksandra Siekierska, James D. Mills, Alessia Romagnolo, Nicole N. Van Der Wel, Eleonora Aronica, Peter A. M. de Witte
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Tuberous sclerosis complex (TSC) is a multisystem genetic disorder caused by pathogenic variants in TSC1 and TSC2 genes. TSC patients present with seizures and brain abnormalities such as tubers and subependymal giant cells astrocytoma (SEGA). Despit
Externí odkaz:
https://doaj.org/article/600537e244ea4c42bc9970aeacc6db1a
Autor:
Yifan Zhang, Lise Heylen, Michèle Partoens, James D. Mills, Rafal M. Kaminski, Patrice Godard, Michel Gillard, Peter A. M. de Witte, Aleksandra Siekierska
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Synaptic vesicle glycoprotein 2A (SV2A) regulates action potential-dependent neurotransmitter release and is commonly known as the primary binding site of an approved anti-epileptic drug, levetiracetam. Although several rodent knockout models have de
Externí odkaz:
https://doaj.org/article/534f33fac8ab4795929ef3e5c79ae077
Autor:
Prakriti Roy, Sophie E van Peer, Martin M de Witte, Godelieve A M Tytgat, Henrike E Karim-Kos, Martine van Grotel, Cees P van de Ven, Annelies M C Mavinkurve-Groothuis, Johannes H M Merks, Roland P Kuiper, Janna A Hol, Geert O R Janssens, Ronald R de Krijger, Marjolijn C J Jongmans, Jarno Drost, Alida F W van der Steeg, Annemieke S Littooij, Marc H W A Wijnen, Harm van Tinteren, Marry M van den Heuvel-Eibrink
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0261729 (2022)
Around 6% of all childhood malignancies represent renal tumors, of which a majority includes Wilms tumor (WT). Although survival rates have improved over the last decades, specific patients are still at risk for adverse outcome. In the Netherlands, s
Externí odkaz:
https://doaj.org/article/cbd09bdea6be4771a698026673ed7536
Autor:
E. Koster, C. Halkes, E. Bogers, C. Hazenberg, F. Heubel-Moenen, S. Langemeier, E. Meijer, E. Nur, M. Raaijmakers, T. Snijders, M. de Witte, J. Tjon, L. de Wreede
Publikováno v:
HemaSphere, Vol 6, Pp 713-714 (2022)
Externí odkaz:
https://doaj.org/article/e6196177cdf34f89b1a1421a2acbe491
Autor:
Lise Heylen, Duc-Hung Pham, Ann-Sofie De Meulemeester, Éric Samarut, Adrianna Skiba, Daniëlle Copmans, Youcef Kazwiny, Pieter Vanden Berghe, Peter A. M. de Witte, Aleksandra Siekierska
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Epilepsy is a common disorder of the brain characterized by spontaneous recurrent seizures, which develop gradually during a process called epileptogenesis. The mechanistic processes underlying the changes of brain tissue and networks toward increase
Externí odkaz:
https://doaj.org/article/be5fabb410974bfb91ab6ba8b49ba5fd
Autor:
Daniëlle Copmans, Sara Kildgaard, Emma Roux, Michèle Partoens, Gert Steurs, Xinhui Wang, Wim M. De Borggraeve, Camila V. Esguerra, Alexander D. Crawford, Thomas O. Larsen, Peter A. M. de Witte
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 247 (2022)
PharmaSea performed large-scale in vivo screening of marine natural product (MNP) extracts, using zebrafish embryos and larvae, to identify compounds with the potential to treat epilepsy. In this study, we report the discovery of two new antiseizure
Externí odkaz:
https://doaj.org/article/367a45b4e88e4608b3466080bf98c684
Autor:
Marlly Guarin, Annelii Ny, Noémie De Croze, Jan Maes, Marc Léonard, Pieter Annaert, Peter A. M. de Witte
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 576 (2021)
Zebrafish embryos (ZFE) have increasingly gained in popularity as a model to perform safety screenings of compounds. Although immersion of ZFE is the main route of exposure used, evidence shows that not all small molecules are equally absorbed, possi
Externí odkaz:
https://doaj.org/article/f700ab93c9b948f184822ffc20e8e96a