Zobrazeno 1 - 10
of 1 266
pro vyhledávání: '"P A Dalgarno"'
The intrinsic dynamics of most proteins are central to their function. Protein tyrosine kinases such as Abl1 undergo significant conformational changes that modulate their activity in response to different stimuli. These conformational changes consti
Externí odkaz:
http://arxiv.org/abs/2405.14968
Autor:
da Silva, Gabriel Monteiro, Cui, Jennifer Y., Dalgarno, David C., Lisi, George P., Rubenstein, Brenda M.
This paper presents a novel approach for predicting the relative populations of protein conformations using AlphaFold 2, an AI-powered method that has revolutionized biology by enabling the accurate prediction of protein structures. While AlphaFold 2
Externí odkaz:
http://arxiv.org/abs/2307.14470
Autor:
Charlie H. T. Kwok, Erika K. Harding, Nicole E. Burma, Tamara Markovic, Nicolas Massaly, Nynke J. van den Hoogen, Sierra Stokes-Heck, Eder Gambeta, Kristina Komarek, Hye Jean Yoon, Kathleen E. Navis, Brendan B. McAllister, Julia Canet-Pons, Churmy Fan, Rebecca Dalgarno, Evgueni Gorobets, James W. Papatzimas, Zizhen Zhang, Yuta Kohro, Connor L. Anderson, Roger J. Thompson, Darren J. Derksen, Jose A. Morón, Gerald W. Zamponi, Tuan Trang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who use prescription or illicit opioids. Hyperactive autonomic output underlies many of the aversive withdrawal symptoms that make it difficult to discontinu
Externí odkaz:
https://doaj.org/article/d65c6d8ddef244efbd66f10b378d8cc2
Autor:
Heather Braund, Jennifer Turnnidge, Nicholas Cofie, Oluwatoyosi Kuforiji, Sarah Greco, Amber Hastings-Truelove, Shannon Hill, Nancy Dalgarno
Publikováno v:
Canadian Medical Education Journal (2024)
Qualitative researchers have underscored the value and importance of being reflexive in the research process, yet existing guidelines or checklists on how to practically address reflexivity are often scant and scattered across studies. In this schola
Externí odkaz:
https://doaj.org/article/f11fe4dfbb7c463cae5f5d95fcd98614
Autor:
Gilla K. Shapiro, Kate Hunt, Heather Braund, Nancy Dalgarno, Aliza A. Panjwani, Sarah Stevens, Jeanne Mulder, Madurika S. Sheth, Alison Stere, Stefanie Green, Gord Gubitz, Madeline Li
Publikováno v:
Journal of Medical Education and Curricular Development, Vol 11 (2024)
Objectives Medical Assistance in Dying (MAiD) was legalized in Canada in 2016, necessitating greater education and training in MAiD for physicians and nurse practitioners. To meet this need, the Canadian MAiD Curriculum (CMC) was developed to offer a
Externí odkaz:
https://doaj.org/article/a968f79a94374807b2abc3ceb2b27b85
Autor:
Gabriel Monteiro da Silva, Jennifer Y. Cui, David C. Dalgarno, George P. Lisi, Brenda M. Rubenstein
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract This paper presents an innovative approach for predicting the relative populations of protein conformations using AlphaFold 2, an AI-powered method that has revolutionized biology by enabling the accurate prediction of protein structures. Wh
Externí odkaz:
https://doaj.org/article/7f2e13d81e424a5eb5b8c27b36adc5cd
Autor:
N. Dalgarno, J. Turnnidge, N. Cofie, R. van Wylick, J. Mulder, F. Kirby, A. Hastings-Truelove, L. Graves
Publikováno v:
BMC Medical Education, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Pain and addiction are one of the most common reasons for adults to seek health care, yet educational programs focused on pain are often underrepresented in medical school curricula. In January 2021, the Association of Faculties o
Externí odkaz:
https://doaj.org/article/1d9614e38e1d4a2ba3cba1fe42d75f16
The precise measurement of a target depth has applications in biophysics and nanophysics, and non-linear optical methods are sensitive to intensity changes on very small length scales. By exploiting the high sensitivity of an autocorrelator's depende
Externí odkaz:
http://arxiv.org/abs/2208.11997
Autor:
Shang Wei Yuan, Xue Dai, Ji Hong Lu, Pei Hua Ma, Scott J. Dalgarno, Carl Redshaw, Zhu Tao, Xin Xiao
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e32936- (2024)
Interaction of the lanthanide nitrates M(NO3)3 (M = Gd, Eu) with methylcucurbit[5]uril (Me10Q[5]) in the presence of transition metal chlorides (ZnCl2 and FeCl3) in acidic media resulted in the isolation of the complexes [Me10Q[5]Gd(H2O)2Cl Gd(H2O)6]
Externí odkaz:
https://doaj.org/article/1627035f1c5249f29f98f053423255c3
Autor:
Jessica Trier, Sussan Askari, Tessa Hanmore, Heather-Ann Thompson, Natalie Wagner, Heather Braund, Andrew Koch Hall, Laura McEwen, Nancy Dalgarno, Jeffrey Damon Dagnone
Publikováno v:
Canadian Medical Education Journal (2024)
Background: As competency-based medical education (CBME) curricula are introduced in residency programs across Canada, systematic evaluation efforts are needed to ensure fidelity of implementation. This study evaluated early outcomes of CBME implemen
Externí odkaz:
https://doaj.org/article/409f7cf5e3ad413685cc054e0d48f88b