Cardiac Troponins Following Repeated Administration of an Iron Chelator – Salicylaldehyd Isonicotinoyl Hydrazone (SIH) – in Rabbits

Autor: Michaela Adamcová, Martin Štěrba, Ivona Klimtová, Tomáš Šimůnek, Radomír Hrdina, Vladimír Geršl, Přemysl Poňka

Publikováno v: Acta Medica, Vol 46, Iss 4, Pp 171-174 (2003)

Both cardiac troponin T (cTnT) and cardiac troponin I (cTnI) are considered to be reliable biomarkers with sufficient sensitivity and specificity for cardiac injury in the majority of laboratory animals. The aim of our study was to compare the diagno

Externí odkaz: https://doaj.org/article/60abc12410fc4255a2de72aabe65f890

Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone

Autor: Tomáš Šimůnek, Olga Popelová, Michaela Adamcova, Přemysl Poňka, Pavlína Hašková, Vladimír Geršl, Milos Hroch, Helena Kaiserová, Martin Štěrba

Publikováno v: British Journal of Pharmacology. 155:138-148

Background and purpose: The clinical utility of anthracycline antineoplastic drugs is limited by the risk of cardiotoxicity, which has been traditionally attributed to iron-mediated production of reactive oxygen species (ROS).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b36effbe86d488a3be9db3b1b54d26a1
https://doi.org/10.1038/bjp.2008.236

Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: a study of salicylaldehyde isonicotinoyl hydrazone (SIH)

Autor: Olga Popelová, Martin Štěrba, Vladimír Geršl, Přemysl Poňka, Tomáš Šimůnek, Vladimir Palicka, Helena Kaiserová, Ivana Gunčová, Michaela Adamcova, A. Potacova, Yvona Mazurová

Publikováno v: Toxicology. 235(3)

Pyridoxal-derived aroylhydrazone iron chelators have been previously shown as effective cardioprotectants against chronic anthracycline cardiotoxicity. In this study we focused on a novel salicylaldehyde analogue (salicylaldehyde isonicotinoyl hydraz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53e4bfbcdfb65c2399c82ee86d59f07
https://pubmed.ncbi.nlm.nih.gov/17459556

SIH - A novel lipophilic iron chelator - Protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death

Autor: Walter Paulus, Tomáš Šimůnek, Jaap J. de Lange, Martin Štěrba, Christa Boer, Přemysl Poňka, Amanda M. G. Versteilen, R. Arthur Bouwman, René J. P. Musters, Ronald Vlasblom, Radomír Hrdina, Vladimír Geršl

Publikováno v: Journal of Molecular and Cellular Cardiology, 39(2), 345-354. Academic Press Inc.
Šimůnek, T, Boer, C, Bouwman, R A, Vlasblom, R, Versteilen, A M G, Štěrba, M, Geršl, V, Hrdina, R, Poňka, P, De Lange, J J, Paulus, W J & Musters, R J P 2005, ' SIH-A novel lipophilic iron chelator-Protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death ', Journal of Molecular and Cellular Cardiology, vol. 39, no. 2, pp. 345-354 . https://doi.org/10.1016/j.yjmcc.2005.05.008

Recent evidence suggests that oxidative stress is a common denominator in many aspects of cardiovascular pathogenesis. Free cellular iron plays a crucial catalytic role in the formation of highly toxic hydroxyl radicals, and thereby it may aggravate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba2e05d77d265c8d63d49d270409173
https://research.vumc.nl/en/publications/d965c94f-5015-4cb9-847e-ff616c004fb9

Development of high-performance liquid chromatographic determination of salicylaldehyde isonicotinoyl hydrazone in rabbit plasma and application of this method to an in vivo study.

Autor: Jiří Klimeš, Martin Štěrba, Olga Popelová, Milan Mokrý, Vladimír Geršl, Přemysl Poňka

Publikováno v: Journal of Separation Science; Aug2005, Vol. 28 Issue 12, p1300-1306, 7p