Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Péter Árva"'
Autor:
Yiping Mao, Jacob Schoenborn, Zhihong Wang, Xinqian Chen, Katy Matson, Ramkumar Mohan, Shungang Zhang, Xiaohu Tang, Anoop Arunagiri, Peter Arvan, Xiaoqing Tang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Abnormal microRNA functions are closely associated with pancreatic β-cell loss and dysfunction in type 2 diabetes. Dysregulation of miR-30d has been reported in the individuals with diabetes. To study how miR-30d affects pancreatic β-cell
Externí odkaz:
https://doaj.org/article/a123c61d7bb345f39e22cb824dcbbaa2
Autor:
Anoop Arunagiri, Leena Haataja, Anita Pottekat, Fawnnie Pamenan, Soohyun Kim, Lori M Zeltser, Adrienne W Paton, James C Paton, Billy Tsai, Pamela Itkin-Ansari, Randal J Kaufman, Ming Liu, Peter Arvan
Publikováno v:
eLife, Vol 8 (2019)
Biosynthesis of insulin – critical to metabolic homeostasis – begins with folding of the proinsulin precursor, including formation of three evolutionarily conserved intramolecular disulfide bonds. Remarkably, normal pancreatic islets contain a su
Externí odkaz:
https://doaj.org/article/e7a8653824104c16932bbe4cb7da543b
Autor:
Insook Jang, Anita Pottekat, Juthakorn Poothong, Jing Yong, Jacqueline Lagunas-Acosta, Adriana Charbono, Zhouji Chen, Donalyn L Scheuner, Ming Liu, Pamela Itkin-Ansari, Peter Arvan, Randal J Kaufman
Publikováno v:
eLife, Vol 8 (2019)
Regulated proinsulin biosynthesis, disulfide bond formation and ER redox homeostasis are essential to prevent Type two diabetes. In ß cells, protein disulfide isomerase A1 (PDIA1/P4HB), the most abundant ER oxidoreductase of over 17 members, can int
Externí odkaz:
https://doaj.org/article/606748e9851d4069a19e7e64c04c8f22
Autor:
Xing-Huang Gao, Dawid Krokowski, Bo-Jhih Guan, Ilya Bederman, Mithu Majumder, Marc Parisien, Luda Diatchenko, Omer Kabil, Belinda Willard, Ruma Banerjee, Benlian Wang, Gurkan Bebek, Charles R. Evans, Paul L. Fox, Stanton L. Gerson, Charles L. Hoppel, Ming Liu, Peter Arvan, Maria Hatzoglou
Publikováno v:
eLife, Vol 4 (2015)
The sulfhydration of cysteine residues in proteins is an important mechanism involved in diverse biological processes. We have developed a proteomics approach to quantitatively profile the changes of sulfhydrated cysteines in biological systems. Bioi
Externí odkaz:
https://doaj.org/article/e21f9334336b43e49725e9f9cd22281d
Autor:
Diva Jonatan, Jason R Spence, Anna M Method, Matthew Kofron, Katie Sinagoga, Leena Haataja, Peter Arvan, Gail H Deutsch, James M Wells
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104675 (2014)
SOX17 is a key transcriptional regulator that can act by regulating other transcription factors including HNF1β and FOXA2, which are known to regulate postnatal β cell function. Given this, we investigated the role of SOX17 in the developing and po
Externí odkaz:
https://doaj.org/article/f5124dfa576d453baf6295150212c72d
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114619- (2024)
Summary: Autophagosome formation initiated on the endoplasmic reticulum (ER)-associated omegasome requires LC3. Translational regulation of LC3 biosynthesis is unexplored. Here we demonstrate that LC3 mRNA is recruited to omegasomes by directly bindi
Externí odkaz:
https://doaj.org/article/849a6267d168498c9640001419faf8ca
Autor:
Catherine C. Robertson, Ruth M. Elgamal, Belle A. Henry-Kanarek, Peter Arvan, Shuibing Chen, Sangeeta Dhawan, Decio L. Eizirik, John S. Kaddis, Golnaz Vahedi, Stephen C.J. Parker, Kyle J. Gaulton, Scott A. Soleimanpour
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101973- (2024)
Background: Type 1 diabetes (T1D) is a complex multi-system disease which arises from both environmental and genetic factors, resulting in the destruction of insulin-producing pancreatic beta cells. Over the past two decades, human genetic studies ha
Externí odkaz:
https://doaj.org/article/2fd0a447e207481d8751377f9c298a7a
Autor:
Yu-Te Yeh, Chandan Sona, Xin Yan, Yunxiao Li, Adrija Pathak, Mark I. McDermott, Zhigang Xie, Liangwen Liu, Anoop Arunagiri, Yuting Wang, Amaury Cazenave-Gassiot, Adhideb Ghosh, Ferdinand von Meyenn, Sivarajan Kumarasamy, Sonia M. Najjar, Shiqi Jia, Markus R. Wenk, Alexis Traynor-Kaplan, Peter Arvan, Sebastian Barg, Vytas A. Bankaitis, Matthew N. Poy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns) 4-OH kina
Externí odkaz:
https://doaj.org/article/07e41593908f4d84a89d335f3da86332
Autor:
Yuwei Zhang, Lina Sui, Qian Du, Leena Haataja, Yishu Yin, Ryan Viola, Shuangyi Xu, Christian Ulrik Nielsson, Rudolph L. Leibel, Fabrizio Barbetti, Peter Arvan, Dieter Egli
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101879- (2024)
Objective: Heterozygous coding sequence mutations of the INS gene are a cause of permanent neonatal diabetes (PNDM), requiring insulin therapy similar to T1D. While the negative effects on insulin processing and secretion are known, how dominant insu
Externí odkaz:
https://doaj.org/article/8fce543b22c7434f8a6ea4fc5678ee55
Autor:
István Sajtos, Péter Árva
Publikováno v:
Építés - Építészettudomány. 40:211-240
A mai mernoki gyakorlatban a falazatok alakvaltozasi jellemzőit kiserleteken alapulo, fenomenologiai osszefuggesek segitsegevel hatarozzak meg. A cikkben arra a kerdesre keressuk a valaszt, hogy meg lehet-e hatarozni a falazatot alkoto osszetevők
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca656957312d6e80475f05c052faa3d1
https://doi.org/10.1556/eptud.40.2012.3-4.2
https://doi.org/10.1556/eptud.40.2012.3-4.2