Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Péter, Mátyus"'
Autor:
Aiman Saleh A. Mohammed, Muhammad Naveed, Tamara Szabados, István Szatmári, Bálint Lőrinczi, Péter Mátyus, Andrea Czompa, Péter Orvos, Zoltán Husti, Tibor Hornyik, Leila Topal, Szilvia Déri, Norbert Jost, László Virág, Péter Bencsik, István Baczkó, András Varró
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract The antiarrhythmic and cardiac electrophysiological effects of SZV-2649 that contains a 2,6-diiodophenoxy moiety but lacks the benzofuran ring system present in amiodarone, were studied in mammalian cell line, rat and dog cardiac preparation
Externí odkaz:
https://doaj.org/article/5d4fa82f0b174061a914887e2d1f4166
Autor:
Ádám István Horváth, Kata Bölcskei, Nikolett Szentes, Éva Borbély, Valéria Tékus, Bálint Botz, Kitti Rusznák, Anett Futácsi, Boldizsár Czéh, Péter Mátyus, Zsuzsanna Helyes
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionMonoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxa
Externí odkaz:
https://doaj.org/article/7cfe2dd453ac46c1bfdceb5f12491f4b
Publikováno v:
Molecules, Vol 29, Iss 18, p 4475 (2024)
Drug innovation traditionally follows a de novo approach with new molecules through a complex preclinical and clinical pathway. In addition to this strategy, drug repositioning has also become an important complementary approach, which can be shorter
Externí odkaz:
https://doaj.org/article/584ed11c5ac343a1977fc2c059bcc97c
Autor:
Anita Csorba, Gábor Katona, Mária Budai-Szűcs, Diána Balogh-Weiser, Anna Maria Fadda, Carla Caddeo, Ágnes Ildikó Takács, Péter Mátyus, György T. Balogh, Zoltán Zsolt Nagy
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Ascorbic acid (AA) has a pivotal role in corneal wound healing via stimulating the biosynthesis of highly organized extracellular matrix components, but its rapid degradation and low corneal permeability limits its therapeutic effects. In th
Externí odkaz:
https://doaj.org/article/571c73be8b414fdab6a52cf6f6ab5177
Publikováno v:
Chemistry, Vol 4, Iss 2, Pp 216-258 (2022)
Viruses, and in particular, RNA viruses, dominate the WHO’s current list of ten global health threats. Of these, we review the widespread and most common HIV, influenza virus, and SARS-CoV-2 infections, as well as their possible prevention by vacci
Externí odkaz:
https://doaj.org/article/d622a769618248d8b9e0162589c32083
Autor:
Lucía Pérez-Regidor, Joan Guzmán-Caldentey, Nils Oberhauser, Carmen Punzón, Balázs Balogh, José R. Pedro, Eva Falomir, Alessandra Nurisso, Péter Mátyus, J. Carlos Menéndez, Belén de Andrés, Manuel Fresno, Sonsoles Martín-Santamaría
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2326 (2022)
The innate immunity toll-like receptor 4 (TLR4) system is a receptor of paramount importance as a therapeutic target. Virtual screening following a “computer-aided drug repurposing” approach was applied to the discovery of novel TLR4 modulators w
Externí odkaz:
https://doaj.org/article/0f1178007a05470795f7fc9e89be0e3d
Autor:
Christian Carpéné, Pénélope Viana, Zsuzsa Iffiú-Soltesz, Pál Tapolcsányi, Anna Ágota Földi, Péter Mátyus, Petra Dunkel
Publikováno v:
Molecules, Vol 27, Iss 19, p 6224 (2022)
Benzylamine is a natural molecule present in food and edible plants, capable of activating hexose uptake and inhibiting lipolysis in human fat cells. These effects are dependent on its oxidation by amine oxidases present in adipocytes, and on the sub
Externí odkaz:
https://doaj.org/article/238b69a6497d4096b3e68f60dfbd7609
Autor:
Valéria Tékus, Ádám István Horváth, Kata Csekő, Krisztina Szabadfi, Andrea Kovács-Valasek, Bese Dányádi, László Deres, Róbert Halmosi, Éva Sághy, Zoltán V. Varga, Ernest Adeghate, Tamás Kőszegi, Péter Mátyus, Róbert Gábriel, Péter Ferdinandy, Erika Pintér, Zsuzsanna Helyes
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 134, Iss , Pp 111105- (2021)
Diabetes mellitus is a common metabolic disease leading to hyperglycemia due to insufficient pancreatic insulin production or effect. Amine oxidase copper containing 3 (AOC3) is an enzyme that belongs to the semicarbazide-sensitive amine oxidase fami
Externí odkaz:
https://doaj.org/article/58d82bcd6dbd4df3904db0c3d4c3209c
Autor:
Rita Meleddu, Angela Corona, Simona Distinto, Filippo Cottiglia, Serenella Deplano, Lisa Sequeira, Daniela Secci, Alessia Onali, Erica Sanna, Francesca Esposito, Italo Cirone, Francesco Ortuso, Stefano Alcaro, Enzo Tramontano, Péter Mátyus, Elias Maccioni
Publikováno v:
Molecules, Vol 26, Iss 13, p 3821 (2021)
Current therapeutic protocols for the treatment of HIV infection consist of the combination of diverse anti-retroviral drugs in order to reduce the selection of resistant mutants and to allow for the use of lower doses of each single agent to reduce
Externí odkaz:
https://doaj.org/article/1ad3314eb0a74fe68b34c1c275aa5a3f
Autor:
Ádám István Horváth, Nikolett Szentes, Valéria Tékus, Maja Payrits, Éva Szőke, Emőke Oláh, András Garami, Eszter Fliszár-Nyúl, Miklós Poór, Cecília Sár, Tamás Kálai, Szilárd Pál, Krisztina Percze, Éva Nagyné Scholz, Tamás Mészáros, Blanka Tóth, Péter Mátyus, Zsuzsanna Helyes
Publikováno v:
Biomedicines, Vol 9, Iss 7, p 749 (2021)
SZV 1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime) is a novel multi-target candidate under preclinical development for neuropathic pain. It inhibits amine oxidase copper containing 3, transient receptor potential ankyrin 1 and vanilloid 1 (TRP
Externí odkaz:
https://doaj.org/article/b78a30cd91f84207aab5435c4944b4c9