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Akademický článek
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Akademický článek
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Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
Consejo Superior de Investigaciones Científicas (CSIC)
Consejo Superior de Investigaciones Científicas (CSIC)
La Enfermedad de Chagas (EC) es todavía, a día de hoy, una enfermedad tropical desatendida (NTD) que afecta y pone en peligro a millones de personas en todo el mundo. Los tratamientos existentes distan de ser los ideales, ya que sus numerosos efect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5b275e904f5c2b81eb22d3453600147d
https://hdl.handle.net/10171/61961
https://hdl.handle.net/10171/61961
Autor:
Beltrán-Hortelano, I. (Iván), Alcolea-Devesa, V. (Verónica), Font, M. (María), Pérez-Silanes, S. (Silvia)
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
instname
Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and institutions, CD is still an important human health problem worldwide. A lack of
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
instname
Chagas disease is considered a neglected tropical disease that continues to endanger millions of people around the world. The current chemotherapy presents some disadvantages such as variable antiparasitic activity, undesired side effects and/or long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9ff2abcf7cd6b3bf153ac192a5dda172
https://hdl.handle.net/10171/57977
https://hdl.handle.net/10171/57977
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
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Chagas Disease (CD) and Leishmaniasis are two parasitic diseases transmitted by vectors and caused by protozoa from the Trypanosomatidae family. Both diseases are included within the neglected tropical diseases group and are caused by Trypanosoma cru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cde7ab5eab66734db5cb40bbe130c736
https://hdl.handle.net/10171/53289
https://hdl.handle.net/10171/53289
Autor:
Pérez-Silanes, S. (Silvia), Torres, E. (Enrique), Arbillaga, L. (Leire), Varela, J. (Javier), Cerecetto, H. (Hugo), Gonzalez, M. (Mercedes), Azqueta, A. (Amaya), Moreno-de-Viguri, E. (Elsa)
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
instname
We report the synthesis and in vitro activity against T. cruzi epimastigotes of 15 novel quinoxaline derivatives. Ten of the derivatives presented IC50 values lower than the reference drugs Nfx and Bzn; four of them standed out with IC50 values lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::be2dade6731d4903a9986ec59e5eca6f
https://hdl.handle.net/10171/40413
https://hdl.handle.net/10171/40413
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
instname
More than 100 million people are at risk of contracting Chagas disease. It is estimated that in 2008, Chagas disease was responsible for the death of more than 10,000 people. Despite the fact that there are more than 100 years since the disease was d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2b8603dc87d66b1b30ca254791a23aa6
https://hdl.handle.net/10171/35800
https://hdl.handle.net/10171/35800
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
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The experimental work presented in this memory is based on the hypothesis that quinoxalines di-N-oxide, considered to be the core of the structure, which present a carboxamide moiety on position two and aliphatic linker between this group and an arom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a223efe174a5a63dfd93803ed255cc31
https://hdl.handle.net/10171/34367
https://hdl.handle.net/10171/34367