Synthesis of SARS-CoV-2 M ^pro inhibitors bearing a cinnamic ester warhead with in vitro activity against human coronaviruses.

Autor: Citarella A; Department of Chemistry, University of Milan, Via Golgi 19, 20133, Milano, Italy. andrea.citarella@unimi.it., Moi D; Dipartimento di Scienze Chimiche e Geologiche, Università di Cagliari, Cittadella Universitaria - S.S. 554 bivio per Sestu, 09042, Monserrato, CA, Italy. davide.moi2@gmail.com., Pedrini M; Department of Chemistry, University of Milan, Via Golgi 19, 20133, Milano, Italy. andrea.citarella@unimi.it., Pérez-Peña H; Department of Chemistry, University of Milan, Via Golgi 19, 20133, Milano, Italy. andrea.citarella@unimi.it., Pieraccini S; Department of Chemistry, University of Milan, Via Golgi 19, 20133, Milano, Italy. andrea.citarella@unimi.it., Dimasi A; Department of Chemistry, University of Milan, Via Golgi 19, 20133, Milano, Italy. andrea.citarella@unimi.it., Stagno C; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, I-98166 Messina, Italy., Micale N; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, I-98166 Messina, Italy., Schirmeister T; Department of Medicinal Chemistry, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany., Sibille G; Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123, Torino, Italy., Gribaudo G; Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123, Torino, Italy., Silvani A; Department of Chemistry, University of Milan, Via Golgi 19, 20133, Milano, Italy. andrea.citarella@unimi.it., Giannini C; Department of Chemistry, University of Milan, Via Golgi 19, 20133, Milano, Italy. andrea.citarella@unimi.it., Passarella D; Department of Chemistry, University of Milan, Via Golgi 19, 20133, Milano, Italy. andrea.citarella@unimi.it.

Publikováno v: Organic & biomolecular chemistry [Org Biomol Chem] 2023 May 10; Vol. 21 (18), pp. 3811-3824. Date of Electronic Publication: 2023 May 10.

Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics.

Autor: Boiarska Z; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Pérez-Peña H; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Abel AC; Laboratory of Biomolecular Research, Paul Scherrer Institute, Forschungsstrasse 111, 5232, Villigen PSI, Switzerland., Marzullo P; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Álvarez-Bernad B; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas Ramiro de Maeztu 9, 28040, Madrid, Spain., Bonato F; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas Ramiro de Maeztu 9, 28040, Madrid, Spain., Santini B; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Horvath D; Laboratory of Chemoinformatics, Faculty of Chemistry, University of Strasbourg, rue B. Pascal, 67081, Strasbourg, France., Lucena-Agell D; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas Ramiro de Maeztu 9, 28040, Madrid, Spain., Vasile F; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Sironi M; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Díaz JF; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas Ramiro de Maeztu 9, 28040, Madrid, Spain., Prota AE; Laboratory of Biomolecular Research, Paul Scherrer Institute, Forschungsstrasse 111, 5232, Villigen PSI, Switzerland., Pieraccini S; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Passarella D; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Jan 24; Vol. 29 (5), pp. e202300069.

Uncovering population structure in a collection of spanish bread wheat landraces

Autor: Pascual Bañuls, Laura, Giraldo Carbajo, Patricia, López Fernández, Matilde, Pérez Peña, H., Fite Sánchez, María Rosario, Benavente Barzana, M. Elena, Vazquez Muñiz, Jose Francisco, Ruiz Valcarcel, María Magdalena

Publikováno v: 1st International Wheat Congress | 1st International Wheat Congress | 22/07/2019-26/07/2019 | Saskatoon, Saskatchewan, Canada
Archivo Digital UPM
Universidad Politécnica de Madrid

Ex situ collections preserve valuable geneticresources collected over time that include germplasm from different genepools. The Spanish bread wheat collection maintained in the Spanish Plant Genetic Resources Center (CRF-INIA) composed by more than 8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2c81a145ffeba6792cc13a7cd3a8e899
http://oa.upm.es/63310/

Rare pathogenic variants in WNK3 cause X-linked intellectual disability.

Autor: Küry S; Nantes Université, CHU Nantes, Service de Génétique Médicale, Nantes, France; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France. Electronic address: sebastien.kury@chu-nantes.fr., Zhang J; Hatherly Laboratories, The Institute of Biomedical and Clinical Sciences, College of Medicine and Health, University of Exeter, Exeter, United Kingdom; Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT; State Key Laboratory of Bio-Organic and Natural Products Chemistry, Research Center of Chemical Kinomics, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China., Besnard T; Nantes Université, CHU Nantes, Service de Génétique Médicale, Nantes, France; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France., Caro-Llopis A; Unidad de Genética, Hospital Universitario y Politécnico La Fe, Valencia, Spain., Zeng X; Department of Genetics, Yale School of Medicine, Yale University, New Haven, CT., Robert SM; Department of Genetics, Yale School of Medicine, Yale University, New Haven, CT., Josiah SS; Hatherly Laboratories, The Institute of Biomedical and Clinical Sciences, College of Medicine and Health, University of Exeter, Exeter, United Kingdom., Kiziltug E; Department of Genetics, Yale School of Medicine, Yale University, New Haven, CT., Denommé-Pichon AS; Département de Biochimie et Génétique, Centre Hospitalier Universitaire Angers, Angers, France; UMR CNRS 6214, INSERM 1083, Université d'Angers, Angers, France., Cogné B; Nantes Université, CHU Nantes, Service de Génétique Médicale, Nantes, France; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France., Kundishora AJ; Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT., Hao LT; Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT., Li H; Departments of Human Genetics and Pediatrics, School of Medicine, Emory University, Atlanta, GA., Stevenson RE; Greenwood Genetic Center, Greenwood, SC., Louie RJ; Greenwood Genetic Center, Greenwood, SC., Deb W; Nantes Université, CHU Nantes, Service de Génétique Médicale, Nantes, France; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France., Torti E; GeneDx, Gaithersburg, MD., Vignard V; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France., McWalter K; GeneDx, Gaithersburg, MD., Raymond FL; Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Biomedical Campus Cambridge, Cambridge, United Kingdom., Rajabi F; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA., Ranza E; Medigenome, Swiss Institute of Genomic Medicine, Geneva, Switzerland., Grozeva D; Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Biomedical Campus Cambridge, Cambridge, United Kingdom; Centre for Trials Research, Cardiff University, Cardiff, United Kingdom., Coury SA; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA., Blanc X; Medigenome, Swiss Institute of Genomic Medicine, Geneva, Switzerland., Brischoux-Boucher E; Centre de Génétique Humaine, CHU de Besançon, Université de Bourgogne Franche-Comté, Besançon, France., Keren B; Department of Genetics, Centre de Référence Déficiences Intellectuelles de Causes Rares, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., Õunap K; Department of Clinical Genetics, Genetics and Personalized Medicine Clinic, Tartu University Hospital, Tartu, Estonia; Department of Clinical Genetics, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia., Reinson K; Department of Clinical Genetics, Genetics and Personalized Medicine Clinic, Tartu University Hospital, Tartu, Estonia; Department of Clinical Genetics, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia., Ilves P; Department of Clinical Genetics, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia; Department of Radiology, Tartu University Hospital, Tartu, Estonia., Wentzensen IM; GeneDx, Gaithersburg, MD., Barr EE; Departments of Human Genetics and Pediatrics, School of Medicine, Emory University, Atlanta, GA., Guihard SH; Department of Genetics, Centre de Référence Déficiences Intellectuelles de Causes Rares, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Groupe de Recherche Clinique, Déficience Intellectuelle et Autisme, Sorbonne University, Paris, France., Charles P; Department of Genetics, Centre de Référence Déficiences Intellectuelles de Causes Rares, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., Seaby EG; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA; Genomic Informatics Group, University of Southampton, Southampton, United Kingdom., Monaghan KG; GeneDx, Gaithersburg, MD., Rio M; Developmental Brain Disorders laboratory, INSERM UMR 1163, Imagine Institute, University of Paris, Paris, France; Department of Genetics, Centre de Référence Déficiences Intellectuelles de Causes Rares, Necker Enfants Malades Hospital, APHP, Paris, France., van Bever Y; Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, the Netherlands., van Slegtenhorst M; Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Chung WK; Departments of Pediatrics and Medicine, Columbia University Irving Medical Center, Columbia University New York, NY., Wilson A; Division of Clinical Genetics, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY., Quinquis D; Nantes Université, CHU Nantes, Service de Génétique Médicale, Nantes, France., Bréhéret F; Nantes Université, CHU Nantes, Service de Génétique Médicale, Nantes, France., Retterer K; GeneDx, Gaithersburg, MD., Lindenbaum P; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France., Scalais E; Division of Pediatric Neurology, Department of Pediatrics, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg., Rhodes L; GeneDx, Gaithersburg, MD., Stouffs K; Neurogenetics Research Group, Reproduction and Genetics, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan, Brussels, Belgium., Pereira EM; Division of Clinical Genetics, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY., Berger SM; Division of Clinical Genetics, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY., Milla SS; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, GA., Jaykumar AB; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX., Cobb MH; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX., Panchagnula S; Unidad de Genética, Hospital Universitario y Politécnico La Fe, Valencia, Spain., Duy PQ; Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT., Vincent M; Nantes Université, CHU Nantes, Service de Génétique Médicale, Nantes, France; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France., Mercier S; Nantes Université, CHU Nantes, Service de Génétique Médicale, Nantes, France; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France., Gilbert-Dussardier B; Service de Génétique, CHU Poitiers, Poitiers, France., Le Guillou X; Service de Génétique, CHU Poitiers, Poitiers, France., Audebert-Bellanger S; Génétique Médicale, CHRU Brest, Brest, France., Odent S; Service de Génétique Clinique, ERN ITHACA, CHU Rennes, Rennes, France; Institut de Génétique et Développement de Rennes, IGDR UMR 6290 CNRS, INSERM, IGDR Univ Rennes, Rennes, France., Schmitt S; Nantes Université, CHU Nantes, Service de Génétique Médicale, Nantes, France., Boisseau P; Nantes Université, CHU Nantes, Service de Génétique Médicale, Nantes, France., Bonneau D; Département de Biochimie et Génétique, Centre Hospitalier Universitaire Angers, Angers, France; UMR CNRS 6214, INSERM 1083, Université d'Angers, Angers, France., Toutain A; Unité de Génétique Médicale, Centre Hospitalier Régional Universitaire de Tours, France; Unité Mixte de Recherche 1253, iBrain, Université de Tours, Institut National de la Santé et de la Recherche Médicale, Tours, France., Colin E; Département de Biochimie et Génétique, Centre Hospitalier Universitaire Angers, Angers, France; UMR CNRS 6214, INSERM 1083, Université d'Angers, Angers, France., Pasquier L; Service de Génétique Clinique, ERN ITHACA, CHU Rennes, Rennes, France; Institut de Génétique et Développement de Rennes, IGDR UMR 6290 CNRS, INSERM, IGDR Univ Rennes, Rennes, France., Redon R; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France., Bouman A; Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Rosenfeld JA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX., Friez MJ; Greenwood Genetic Center, Greenwood, SC., Pérez-Peña H; Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, University College London, London, United Kingdom., Akhtar Rizvi SR; Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, University College London, London, United Kingdom., Haider S; Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, University College London, London, United Kingdom; Centre for Advanced Research Computing, University College London, London, United Kingdom., Antonarakis SE; Medigenome, Swiss Institute of Genomic Medicine, Geneva, Switzerland; Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland; iGE3, Institute of Genetics and Genomics of Geneva, University of Geneva, Geneva, Switzerland., Schwartz CE; Greenwood Genetic Center, Greenwood, SC., Martínez F; Unidad de Genética, Hospital Universitario y Politécnico La Fe, Valencia, Spain., Bézieau S; Nantes Université, CHU Nantes, Service de Génétique Médicale, Nantes, France; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France., Kahle KT; Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT; Department of Cellular and Molecular Physiology, Yale School of Medicine, Yale University, New Haven, CT; NIH-Yale Centers for Mendelian Genomics, Yale School of Medicine, Yale University, New Haven, CT; Yale Stem Cell Center, Yale School of Medicine, Yale University, New Haven, CT. Electronic address: kahle.kristopher@mgh.harvard.edu., Isidor B; Nantes Université, CHU Nantes, Service de Génétique Médicale, Nantes, France; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.

Publikováno v: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2022 Sep; Vol. 24 (9), pp. 1941-1951. Date of Electronic Publication: 2022 Jun 09.

Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders.

Autor: Marzullo P; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Boiarska Z; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Pérez-Peña H; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Abel AC; Laboratory of Biomolecular Research, Paul Scherrer Institute, Forschungsstrasse 111, 5232, Villigen PSI, Switzerland., Álvarez-Bernad B; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040, Madrid, Spain., Lucena-Agell D; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040, Madrid, Spain., Vasile F; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Sironi M; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Altmann KH; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH, Zürich, Vladimir-Prelog Weg 4, HCI H405, 8093, Zürich, Switzerland., Prota AE; Laboratory of Biomolecular Research, Paul Scherrer Institute, Forschungsstrasse 111, 5232, Villigen PSI, Switzerland., Díaz JF; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040, Madrid, Spain., Pieraccini S; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy., Passarella D; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 Jan 10; Vol. 28 (2), pp. e202103520. Date of Electronic Publication: 2021 Nov 29.